Protein Alignment f and Espn

DIOPT Version :10

• Sequence 1: NP_001036284.1
• Gene: f / 32718
• FlyBaseID: FBgn0262111
• Length: 1918
• Species: Drosophila melanogaster
• Sequence 2: XP_006539122.1
• Gene: Espn / 56226
• MGIID: 1861630
• Length: 896
• Species: Mus musculus
• Alignment Length: 1585
• Identity: 283/1585 - (17%)
• Similarity: 436/1585 - (27%)
• Gaps: 810/1585 - (51%)

  Fly   349 GGMGQVGQMYHPGSVSGSERPNGGALALHYAAARGCLDCVQLLVAASVDICYFSTINVKKGLLGR 413
            |.:..:..::..|.:..|.|.:..||.:|:||..|.|.|::.||.   ::...:....:.|....
Mouse    13 GDLDVLRSLHAAGLLGPSLRDSLDALPVHHAARSGKLHCLRYLVE---EVALPAVSRARNGATPA 74

  Fly   414 MTTSLTSYR------------RSKQKSKSNNDIHTIIA----TEVVTAAILSSSVHSSSTGSEIG 462
            ...:.|.|.            |.::|..|...:..:.|    .:||...:.....:|:.|    .
Mouse    75 HDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLLYQGGANSAIT----T 135

  Fly   463 DGGQGNTSLIEEAAAQDQSSEEQDRQHQHAKDPLAQTEMNHHPHSHHQRKSAVEVVRQQMDDDGD 527
            |.|   ...|..|||:...             |..:..:.|:|
Mouse   136 DTG---ALPIHYAAAKGDL-------------PSLKLLVGHYP---------------------- 162

  Fly   528 QDSNDDDETMPMMSGVGRKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAGGSLY 592
                         .||              |.|.:|..||:|||.|||||||.|:||.|.....:
Mouse   163 -------------EGV--------------NAQTNNGATPLYLACQEGHLEVTKYLVQECSADPH 200

  Fly   593 VRARDGMAPIHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLNHGAK 657
            :||:|||.|:|||:|||....|.|:|....|..:.:|.||||.:||||||||..|:.|||.|||:
Mouse   201 LRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAE 265

  Fly   658 LSLDKYGKSPINDAAENQQVECLNVLVQHGTSVD--------------YNGKSSSQRH-KSQQQL 707
            :|.|.:|.:|::|||||.::||..:|..:|..:|              :||.:...|: ::.|.|
Mouse   266 ISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLAEFNGHTHCSRYLRTVQTL 330

  Fly   708 HQQHQQQQQQQQQQHLSSSCNSNSNSSKQTSRSNTIKSKSSSTLSSDVEPFYLHPPALAGGSGGS 772
            ..:|:...:.|                                 |.|:|
Mouse   331 SLEHRVLSRDQ---------------------------------SMDLE---------------- 346

  Fly   773 GMGLGMGMGMGMGMSMGLGISRKNSDALYSQQSRSSSEKLYNGSSSLGGNPGGNSSSGGGGVGGG 837
                                                :::|.:|.||
Mouse   347 ------------------------------------AKQLDSGMSS------------------- 356

  Fly   838 GGSGGALLPNDGLYVNPMRNGGMYNTPSPNGSISGESFFLHDPQDIIYNRVRDLFVDSDCSSSVK 902
                    ||..:.|.||    .::..||..:.|.                    .|| ||||
Mouse   357 --------PNTTMSVQPM----TFDLGSPTSTFSN--------------------YDS-CSSS-- 386

  Fly   903 QHGKSHAHQLLQSKAGNAMTIQADVHSSSSGAGSGSDESVSISSSFNSPKQQQQLRSQSFNRHGS 967
                                     ||||.|
Mouse   387 -------------------------HSSSKG---------------------------------- 392

  Fly   968 SSNISASGNIKNNNYKAHKGKPSNQNGGGDHDYEDIYLVREESRKQHQQQQQHQLQQQQQLQHQA 1032
                          .::::|.|
Mouse   393 --------------QRSNRGIP------------------------------------------- 400

  Fly  1033 TQQQQQQQQQQQQLQHKYNVGRSRSRDSGSHSRSASASSTRSTDIVLQYSNHHLNNKRNMNNNSN 1097
                                                  ..|:.|:
Mouse   401 --------------------------------------GARAADL-------------------- 407

  Fly  1098 MNNSSSNIAQSSSSNNNNNSLLNRNKSHSIIGLHSSKYESSLKDNYSAKNVNLKNQLLNGGIKSD 1162
                                                                            .
Mouse   408 ----------------------------------------------------------------Q 408

  Fly  1163 TYESVCPPEDVAERTKQTHKNSMIRNNLADASSNNNTSGSINNISNIGNMNGGNQSSRNLKRVSS 1227
            :|..:..||           .|:.|..|...|
Mouse   409 SYMDMLNPE-----------KSLPRGKLGKPS--------------------------------- 429

  Fly  1228 APPMQNLAVVNGPPPPPLPPPLRAPVQQQRNNLSVDQPNSMTGNNGIYKKNVFGPNQGPTNANGT 1292
                        |||||.|||                |:             |.|...||   ||
Mouse   430 ------------PPPPPPPPP----------------PS-------------FPPPPPPT---GT 450

  Fly  1293 GGAAPPP-VPAPNPVATEAVDSDSGLEVVEEPSLRPSELVRGNHNRTMSTISANKKAKLLNAGST 1356
            ....||| .|||||..        ||.:               :|..|.|   ..|.:.:...|.
Mouse   451 QPPPPPPGYPAPNPPV--------GLHL---------------NNIYMQT---KNKLRHVEVDSL 489

  Fly  1357 NGSSIAASSDDSQSRYGGSVHAANGSAANGHFYGYSEGNKNQGSNGNGNGNGNGGGGNYHSHPNQ 1421
            ....:..:...:|.                             |:|:|           ||
Mouse   490 KEPKVELNDQFAQP-----------------------------SSGDG-----------HS---- 510

  Fly  1422 PHYATGQPHQYTPSLYGGGSSAEDHYELTQQQQQIYGETHLPSGQRTGGPNLVNKQLVLPFVPPS 1486
                              |...:|...|.|..:                  |:::|
Mouse   511 ------------------GLHRQDSGLLRQDSE------------------LLHRQ--------- 530

  Fly  1487 FPNKSQDGVTHLIKPSEYLKSISIDKRSCPSSARSTDTEDYMQIQIAQQQSHP--------HQHQ 1543
                      .|::.|..|:....|::. .|.::...|.||.: |:.:....|        |..:
Mouse   531 ----------ELLRHSTGLRRQDSDRKQ-RSFSKQPSTGDYYR-QLGRSPGEPLAARPGMAHSEE 583

  Fly  1544 HHPHPHPHPHHPHQLHGMG--EQPPLPPPPPPLPHGMLPPQPPMGPPM-----GVAGGQDATMS- 1600
            ....|..|.|:........  |.|| ||||||||..:  ..||..||:     |.|.||..:.|
Mouse   584 AALLPGNHVHNGCSADSKASRELPP-PPPPPPLPEAL--SSPPPAPPLPIEGAGAACGQRRSSSS 645

  Fly  1601 ----------------------------------GKSHKPKKPHGSAPNSQDTAT--RKQHQPLS 1629
                                              |||.||      .|.|:...|  ....||.|
Mouse   646 TGKVRVLRHRKSTKSFNMMSPTGDNSELLAEIKAGKSLKP------TPQSKGLTTVFSGSGQPAS 704

  Fly  1630 AISIQDLNSVQLRRTDTQKVP--KPY--------------QMPARSLSMQCLTSSTETYLKSDLI 1678
            .:     .:.::.|..:|.:|  :||              ..|:|:.|.....|.::..|...::
Mouse   705 QV-----GTGRVPRPGSQCLPSAQPYCFSRQPESPQPLVSPAPSRTRSPTPPASGSQPLLNGSVV 764

  Fly  1679 AELKISKDIPGIKKMKVEQQMASRMDSEHYMEITKQFSGNNYVDQIPERDQAGNAIPDWKRQMMA 1743
             ....:...||:           .:|.|..               ||..|:.|..||:||||:|.
Mouse   765 -PAPPATPAPGV-----------HLDVEAL---------------IPTLDEQGRPIPEWKRQVMV 802

  Fly  1744 KKAAERAKKDFEERMAQEAESRRLSQIPQWKRDLLARREETENKLKAAIYTPKVEENNRVADTWR 1808
            :|..::.:::.|:|..:|.|..||:.:|.|:||:|.::.|.|.:.|.     |.||..::.:..|
Mouse   803 RKLQQKMQEEEEQRRKEEEEEARLASLPAWRRDILRKKLEEEREQKR-----KEEERQKLEEIQR 862

  Fly  1809 LKNRAMSIDNININLAGMEQHYQQI 1833
            .|.::..:..:..:.|.:....:|:
Mouse   863 AKEQSEKLRTLGYDEAKLAPWQRQV 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
f	NP_001036284.1	ANK repeat	371..399	CDD:293786	10/27 (37%)
		ANKYR	<558..695	CDD:440430	70/150 (47%)
		ANK repeat	566..595	CDD:293786	16/28 (57%)
		ANK repeat	597..629	CDD:293786	14/31 (45%)
		ANK repeat	631..660	CDD:293786	19/28 (68%)
		ANK repeat	663..691	CDD:293786	11/27 (41%)
Espn	XP_006539122.1	Ank_4	8..56	CDD:372654	12/42 (29%)
		ANK repeat	39..67	CDD:293786	8/30 (27%)
		Ank_2	41..127	CDD:463710	17/88 (19%)
		ANK repeat	69..101	CDD:293786	4/31 (13%)
		ANKYR	100..324	CDD:440430	90/292 (31%)
		ANK repeat	103..135	CDD:293786	6/35 (17%)
		ANK repeat	137..169	CDD:293786	11/96 (11%)
		ANK repeat	171..202	CDD:293786	17/30 (57%)
		ANK repeat	205..237	CDD:293786	14/31 (45%)
		ANK repeat	239..269	CDD:293786	20/29 (69%)
		ANK repeat	271..302	CDD:293786	12/30 (40%)
		PHA02682	<650..>757	CDD:177464	20/117 (17%)