DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment f and Espn

DIOPT Version :9

Sequence 1:NP_001036284.1 Gene:f / 32718 FlyBaseID:FBgn0262111 Length:1918 Species:Drosophila melanogaster
Sequence 2:XP_006539122.1 Gene:Espn / 56226 MGIID:1861630 Length:896 Species:Mus musculus


Alignment Length:1585 Identity:283/1585 - (17%)
Similarity:436/1585 - (27%) Gaps:810/1585 - (51%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 GGMGQVGQMYHPGSVSGSERPNGGALALHYAAARGCLDCVQLLVAASVDICYFSTINVKKGLLGR 413
            |.:..:..::..|.:..|.|.:..||.:|:||..|.|.|::.||.   ::...:....:.|....
Mouse    13 GDLDVLRSLHAAGLLGPSLRDSLDALPVHHAARSGKLHCLRYLVE---EVALPAVSRARNGATPA 74

  Fly   414 MTTSLTSYR------------RSKQKSKSNNDIHTIIA----TEVVTAAILSSSVHSSSTGSEIG 462
            ...:.|.|.            |.::|..|...:..:.|    .:||...:.....:|:.|    .
Mouse    75 HDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLLYQGGANSAIT----T 135

  Fly   463 DGGQGNTSLIEEAAAQDQSSEEQDRQHQHAKDPLAQTEMNHHPHSHHQRKSAVEVVRQQMDDDGD 527
            |.|   ...|..|||:...             |..:..:.|:|                      
Mouse   136 DTG---ALPIHYAAAKGDL-------------PSLKLLVGHYP---------------------- 162

  Fly   528 QDSNDDDETMPMMSGVGRKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAGGSLY 592
                         .||              |.|.:|..||:|||.|||||||.|:||.|.....:
Mouse   163 -------------EGV--------------NAQTNNGATPLYLACQEGHLEVTKYLVQECSADPH 200

  Fly   593 VRARDGMAPIHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLNHGAK 657
            :||:|||.|:|||:|||....|.|:|....|..:.:|.||||.:||||||||..|:.|||.|||:
Mouse   201 LRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAE 265

  Fly   658 LSLDKYGKSPINDAAENQQVECLNVLVQHGTSVD--------------YNGKSSSQRH-KSQQQL 707
            :|.|.:|.:|::|||||.::||..:|..:|..:|              :||.:...|: ::.|.|
Mouse   266 ISQDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLAEFNGHTHCSRYLRTVQTL 330

  Fly   708 HQQHQQQQQQQQQQHLSSSCNSNSNSSKQTSRSNTIKSKSSSTLSSDVEPFYLHPPALAGGSGGS 772
            ..:|:...:.|                                 |.|:|                
Mouse   331 SLEHRVLSRDQ---------------------------------SMDLE---------------- 346

  Fly   773 GMGLGMGMGMGMGMSMGLGISRKNSDALYSQQSRSSSEKLYNGSSSLGGNPGGNSSSGGGGVGGG 837
                                                :::|.:|.||                   
Mouse   347 ------------------------------------AKQLDSGMSS------------------- 356

  Fly   838 GGSGGALLPNDGLYVNPMRNGGMYNTPSPNGSISGESFFLHDPQDIIYNRVRDLFVDSDCSSSVK 902
                    ||..:.|.||    .::..||..:.|.                    .|| ||||  
Mouse   357 --------PNTTMSVQPM----TFDLGSPTSTFSN--------------------YDS-CSSS-- 386

  Fly   903 QHGKSHAHQLLQSKAGNAMTIQADVHSSSSGAGSGSDESVSISSSFNSPKQQQQLRSQSFNRHGS 967
                                     ||||.|                                  
Mouse   387 -------------------------HSSSKG---------------------------------- 392

  Fly   968 SSNISASGNIKNNNYKAHKGKPSNQNGGGDHDYEDIYLVREESRKQHQQQQQHQLQQQQQLQHQA 1032
                          .::::|.|                                           
Mouse   393 --------------QRSNRGIP------------------------------------------- 400

  Fly  1033 TQQQQQQQQQQQQLQHKYNVGRSRSRDSGSHSRSASASSTRSTDIVLQYSNHHLNNKRNMNNNSN 1097
                                                  ..|:.|:                    
Mouse   401 --------------------------------------GARAADL-------------------- 407

  Fly  1098 MNNSSSNIAQSSSSNNNNNSLLNRNKSHSIIGLHSSKYESSLKDNYSAKNVNLKNQLLNGGIKSD 1162
                                                                            .
Mouse   408 ----------------------------------------------------------------Q 408

  Fly  1163 TYESVCPPEDVAERTKQTHKNSMIRNNLADASSNNNTSGSINNISNIGNMNGGNQSSRNLKRVSS 1227
            :|..:..||           .|:.|..|...|                                 
Mouse   409 SYMDMLNPE-----------KSLPRGKLGKPS--------------------------------- 429

  Fly  1228 APPMQNLAVVNGPPPPPLPPPLRAPVQQQRNNLSVDQPNSMTGNNGIYKKNVFGPNQGPTNANGT 1292
                        |||||.|||                |:             |.|...||   ||
Mouse   430 ------------PPPPPPPPP----------------PS-------------FPPPPPPT---GT 450

  Fly  1293 GGAAPPP-VPAPNPVATEAVDSDSGLEVVEEPSLRPSELVRGNHNRTMSTISANKKAKLLNAGST 1356
            ....||| .|||||..        ||.:               :|..|.|   ..|.:.:...|.
Mouse   451 QPPPPPPGYPAPNPPV--------GLHL---------------NNIYMQT---KNKLRHVEVDSL 489

  Fly  1357 NGSSIAASSDDSQSRYGGSVHAANGSAANGHFYGYSEGNKNQGSNGNGNGNGNGGGGNYHSHPNQ 1421
            ....:..:...:|.                             |:|:|           ||    
Mouse   490 KEPKVELNDQFAQP-----------------------------SSGDG-----------HS---- 510

  Fly  1422 PHYATGQPHQYTPSLYGGGSSAEDHYELTQQQQQIYGETHLPSGQRTGGPNLVNKQLVLPFVPPS 1486
                              |...:|...|.|..:                  |:::|         
Mouse   511 ------------------GLHRQDSGLLRQDSE------------------LLHRQ--------- 530

  Fly  1487 FPNKSQDGVTHLIKPSEYLKSISIDKRSCPSSARSTDTEDYMQIQIAQQQSHP--------HQHQ 1543
                      .|::.|..|:....|::. .|.::...|.||.: |:.:....|        |..:
Mouse   531 ----------ELLRHSTGLRRQDSDRKQ-RSFSKQPSTGDYYR-QLGRSPGEPLAARPGMAHSEE 583

  Fly  1544 HHPHPHPHPHHPHQLHGMG--EQPPLPPPPPPLPHGMLPPQPPMGPPM-----GVAGGQDATMS- 1600
            ....|..|.|:........  |.|| ||||||||..:  ..||..||:     |.|.||..:.| 
Mouse   584 AALLPGNHVHNGCSADSKASRELPP-PPPPPPLPEAL--SSPPPAPPLPIEGAGAACGQRRSSSS 645

  Fly  1601 ----------------------------------GKSHKPKKPHGSAPNSQDTAT--RKQHQPLS 1629
                                              |||.||      .|.|:...|  ....||.|
Mouse   646 TGKVRVLRHRKSTKSFNMMSPTGDNSELLAEIKAGKSLKP------TPQSKGLTTVFSGSGQPAS 704

  Fly  1630 AISIQDLNSVQLRRTDTQKVP--KPY--------------QMPARSLSMQCLTSSTETYLKSDLI 1678
            .:     .:.::.|..:|.:|  :||              ..|:|:.|.....|.::..|...::
Mouse   705 QV-----GTGRVPRPGSQCLPSAQPYCFSRQPESPQPLVSPAPSRTRSPTPPASGSQPLLNGSVV 764

  Fly  1679 AELKISKDIPGIKKMKVEQQMASRMDSEHYMEITKQFSGNNYVDQIPERDQAGNAIPDWKRQMMA 1743
             ....:...||:           .:|.|..               ||..|:.|..||:||||:|.
Mouse   765 -PAPPATPAPGV-----------HLDVEAL---------------IPTLDEQGRPIPEWKRQVMV 802

  Fly  1744 KKAAERAKKDFEERMAQEAESRRLSQIPQWKRDLLARREETENKLKAAIYTPKVEENNRVADTWR 1808
            :|..::.:::.|:|..:|.|..||:.:|.|:||:|.::.|.|.:.|.     |.||..::.:..|
Mouse   803 RKLQQKMQEEEEQRRKEEEEEARLASLPAWRRDILRKKLEEEREQKR-----KEEERQKLEEIQR 862

  Fly  1809 LKNRAMSIDNININLAGMEQHYQQI 1833
            .|.::..:..:..:.|.:....:|:
Mouse   863 AKEQSEKLRTLGYDEAKLAPWQRQV 887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fNP_001036284.1 Ank_2 <370..400 CDD:289560 10/29 (34%)
ANK repeat 371..399 CDD:293786 10/27 (37%)
ANK 558..684 CDD:238125 66/125 (53%)
Ank_4 565..618 CDD:290365 30/52 (58%)
ANK repeat 566..595 CDD:293786 16/28 (57%)
ANK repeat 597..629 CDD:293786 14/31 (45%)
Ank_2 602..693 CDD:289560 44/104 (42%)
ANK repeat 631..660 CDD:293786 19/28 (68%)
ANK repeat 663..691 CDD:293786 11/27 (41%)
EspnXP_006539122.1 Ank_4 8..56 CDD:372654 12/42 (29%)
ANK repeat 39..67 CDD:293786 8/30 (27%)
Ank_2 41..127 CDD:372319 17/88 (19%)
ANK repeat 69..101 CDD:293786 4/31 (13%)
ANK repeat 103..135 CDD:293786 6/35 (17%)
Ank_2 108..202 CDD:372319 35/162 (22%)
ANK repeat 137..169 CDD:293786 11/96 (11%)
ANK repeat 171..202 CDD:293786 17/30 (57%)
Ank_2 176..266 CDD:372319 50/89 (56%)
ANK repeat 205..237 CDD:293786 14/31 (45%)
ANK repeat 239..269 CDD:293786 20/29 (69%)
Ank_2 244..324 CDD:372319 32/79 (41%)
ANK repeat 271..302 CDD:293786 12/30 (40%)
PHA02682 <650..>757 CDD:177464 20/117 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839414
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BFVQ
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 259 1.000 Inparanoid score I3116
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43734
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24153
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.980

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