DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment f and ESPNL

DIOPT Version :9

Sequence 1:	NP_001036284.1	Gene:	f / 32718	FlyBaseID:	FBgn0262111	Length:	1918	Species:	Drosophila melanogaster
Sequence 2:	NP_919288.2	Gene:	ESPNL / 339768	HGNCID:	27937	Length:	1005	Species:	Homo sapiens

Alignment Length:	624	Identity:	137/624 - (21%)
Similarity:	219/624 - (35%)	Gaps:	188/624 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 GGVGSMMNLGGMGQVGQMYHPGSVSGSERPNGGALALHYAAARGCLDCVQLLVAASVDICYFSTI 404
            |.|.::..|...|.:|    ||.....     ||..:|:|...|.||||:.||
Human    13 GDVATLERLLEAGALG----PGITDAL-----GAGLVHHATRAGHLDCVKFLV------------ 56

  Fly   405 NVKKGLLGRMTTSLTSYRRSKQKSKSNNDIHTIIATEVVTAAILSSSVHSSSTGS------EIGD 463
                     ....|...:|:...:...:|                    :::|||      .:.:
Human    57 ---------QRAQLPGNQRAHNGATPAHD--------------------AAATGSLAELCWLVRE 92

  Fly   464 GGQGNTSLIEEAAAQDQSSEEQDRQHQHAK--DPLAQTEMNHHPHS------------HHQRKSA 514
            ||.|         .|||.:......|..|:  .|:....:.|..||            ||...|.
Human    93 GGCG---------LQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSG 148

  Fly   515 VEVVRQQMDDDGDQDSNDDDETMPMMSGVGRKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLEV 579
                               |.|...:.........|||:...|        :|:|||.|||||.:
Human   149 -------------------DLTCLKLLTAAHGSSVNRRTRSGA--------SPLYLACQEGHLHL 186

  Fly   580 LKFLVLEAGGSLYVRARDGMAPIHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGH 644
            .:|||.:.|..:::||.|||:.:|||:..|....:.|:|....:....||.:|||.|||||..||
Human   187 AQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGH 251

  Fly   645 LSVVRWLLNHGAKLSLDKYGKSPINDAAENQQVECLNVLVQHGTSV---DYNGKSSSQRHKSQQQ 706
            ..::..||..|..:..|.:|.:|::|||||.|:||...||.|....   |.:|.:::       .
Human   252 TPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYTAA-------D 309

  Fly   707 LHQQHQQQQQQQQQQHLSSSCNSNSNSSKQTSRSNTIKSKSSSTLSSDVEPFYLHPPALA----- 766
            |.:.|..:...|..:.:                     ::....|.:...|.:..||.||
Human   310 LAEYHGHRDCAQYLREV---------------------AQPVPLLMTPPPPPFPPPPLLATRRSL 353

  Fly   767 --GGSGGSGMGLGMGMGMGMGMSMGLGISRKNSDALYSQQSRSSSEKLYNGSSSLGGNPGGNSSS 829
              |..||.|.|....|.:.....     ...:......|.:..:..::...:::   :|.|..::
Human   354 EDGRRGGPGPGNPSPMSLSPAWP-----GHPDQPLPREQMTSPAPPRIITSATA---DPEGTETA 410

  Fly   830 GGGGVGGGGGSGGALLPNDGLYVNPMRNGGMYNTPSPNGSISGESFFLHDPQDIIYNRVRDLFVD 894
                :.|....|.|.|..|||               |:|.|.|          ::..|
Human   411 ----LAGDTSDGLAALQLDGL---------------PSGDIDG----------LVPTR------- 439

  Fly   895 SDCSSSVKQHGKSHAHQLLQSKAGNAMTIQADVHSSSSG 933
            .:....:.:..:....:.||::.|...:.:|..:..|||
Human   440 DERGQPIPEWKRQVMVRKLQARLGAESSAEAQDNGGSSG 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f	NP_001036284.1	Ank_2	<370..400	CDD:289560	11/29 (38%)
		ANK repeat	371..399	CDD:293786	11/27 (41%)
		ANK	558..684	CDD:238125	50/125 (40%)
		Ank_4	565..618	CDD:290365	23/52 (44%)
		ANK repeat	566..595	CDD:293786	13/28 (46%)
		ANK repeat	597..629	CDD:293786	9/31 (29%)
		Ank_2	602..693	CDD:289560	36/93 (39%)
		ANK repeat	631..660	CDD:293786	13/28 (46%)
		ANK repeat	663..691	CDD:293786	13/30 (43%)
ESPNL	NP_919288.2	ANK 1	1..31		6/21 (29%)
		Ank_4	8..56	CDD:290365	16/51 (31%)
		ANK	<8..56	CDD:295348	16/51 (31%)
		ANK 2	35..64		12/54 (22%)
		Ank_2	41..133	CDD:289560	27/141 (19%)
		ANK repeat	69..101	CDD:293786	9/60 (15%)
		ANK 3	69..99		7/58 (12%)
		ANK	100..225	CDD:238125	39/151 (26%)
		ANK repeat	103..134	CDD:293786	6/30 (20%)
		ANK 4	103..132		6/28 (21%)
		Ank_2	108..201	CDD:289560	28/119 (24%)
		ANK repeat	136..168	CDD:293786	7/50 (14%)
		ANK 5	136..166		5/48 (10%)
		ANK	165..291	CDD:238125	54/133 (41%)
		ANK repeat	170..201	CDD:293786	14/38 (37%)
		ANK 6	170..200		14/37 (38%)
		ANK 7	204..234		9/29 (31%)
		Ank_2	209..301	CDD:289560	35/91 (38%)
		ANK repeat	238..268	CDD:293786	13/29 (45%)
		ANK 8	238..267		13/28 (46%)
		ANK repeat	270..301	CDD:293786	13/30 (43%)
		ANK 9	270..299		13/28 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..444		27/154 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..483		5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	695..730
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	773..795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41686
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24153
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.030