DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment f and Espnl

DIOPT Version :9

Sequence 1:	NP_001036284.1	Gene:	f / 32718	FlyBaseID:	FBgn0262111	Length:	1918	Species:	Drosophila melanogaster
Sequence 2:	NP_001028464.1	Gene:	Espnl / 227357	MGIID:	2685402	Length:	1005	Species:	Mus musculus

Alignment Length:	444	Identity:	112/444 - (25%)
Similarity:	170/444 - (38%)	Gaps:	124/444 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 GGMGQVGQMYHPGSVSGSERPNGGALALHYAAARGCLDCVQLLVAASVDICYFSTINVKKGLLGR 413
            |.|..:.:::..|::......:.||..:|:|...|.||||:.||
Mouse    13 GDMATLERLFEAGALRPDITDDLGAGLVHHATRAGHLDCVKFLV--------------------- 56

  Fly   414 MTTSLTSYRRSKQKSKSNNDIHTIIATEVVTAAILSSSVHSSSTGS------EIGDGGQGNTSLI 472
                      .:.|...|...|. .||.|..||         :||:      .:.|.|.|
Mouse    57 ----------QRAKLPGNQQAHN-GATPVHDAA---------ATGNLAELCWLVRDAGCG----- 96

  Fly   473 EEAAAQDQSSEEQDRQHQHAK--DPLAQTEMNHHPHS------------HHQRKSAVEVVRQQMD 523
                .|||.:......|..|:  .|.....:....|:            ||...|......:.:
Mouse    97 ----LQDQDASGVSPLHLAARFGHPALVEWLLREGHAATLETLEGALPLHHAAVSGDLTCLKLL- 156

  Fly   524 DDGDQDSNDDDETMPMMSGVGRKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLEVLKFLVLEAG 588
                        |....|||      |:|:...|        :|:|||.|||||.:.:|||.:.|
Mouse   157 ------------TAAHSSGV------NQRTCSGA--------SPLYLACQEGHLHLAQFLVKDCG 195

  Fly   589 GSLYVRARDGMAPIHAASQMGCLDCLKWMVQDQGVDPNLRDGDGATPLHFAASRGHLSVVRWLLN 653
            ..:.:||.|||:.:|||:..|....:.|:|....:....||.:|||.|||||..||..::..||.
Mouse   196 ADVRLRALDGMSSLHAAAAHGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLL 260

  Fly   654 HGAKLSLDKYGKSPINDAAENQQVECLNVLVQHGTSV---DYNGKSSSQRHKSQQQLHQQHQQQQ 715
            .||.:..|.:|.:|::|||||..:||...|:.|....   |.:|.::.       .|.:.|..|.
Mouse   261 MGAPIMRDSWGGTPLHDAAENGHMECCQTLLSHHVDPFLRDEDGYTAI-------DLAEYHGHQD 318

  Fly   716 QQQQQQHLSSSCN----------------SNSNSSKQTSRSNT-IKSKSSSTLS 752
            ..|..:.:|....                :...|.::..|.:: :||.||:|||
Mouse   319 CAQFLREMSRPVRVLMTPPPPPFPPPPLLAAKLSLEEERRGDSGLKSPSSATLS 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f	NP_001036284.1	Ank_2	<370..400	CDD:289560	11/29 (38%)
		ANK repeat	371..399	CDD:293786	11/27 (41%)
		ANK	558..684	CDD:238125	50/125 (40%)
		Ank_4	565..618	CDD:290365	23/52 (44%)
		ANK repeat	566..595	CDD:293786	13/28 (46%)
		ANK repeat	597..629	CDD:293786	9/31 (29%)
		Ank_2	602..693	CDD:289560	35/93 (38%)
		ANK repeat	631..660	CDD:293786	14/28 (50%)
		ANK repeat	663..691	CDD:293786	11/30 (37%)
Espnl	NP_001028464.1	ANK 1	1..31		3/17 (18%)
		Ank_4	8..56	CDD:290365	12/42 (29%)
		ANK	30..156	CDD:238125	34/175 (19%)
		ANK 2	35..64		12/59 (20%)
		Ank_4	39..90	CDD:290365	19/91 (21%)
		ANK repeat	69..101	CDD:293786	12/50 (24%)
		ANK 3	69..99		10/48 (21%)
		Ank_4	72..124	CDD:290365	15/69 (22%)
		ANK	100..225	CDD:238125	38/151 (25%)
		ANK repeat	103..134	CDD:293786	4/30 (13%)
		ANK 4	103..132		4/28 (14%)
		Ank_2	108..201	CDD:289560	27/119 (23%)
		ANK repeat	136..168	CDD:293786	8/50 (16%)
		ANK 5	136..166		7/48 (15%)
		ANK repeat	170..202	CDD:293786	14/39 (36%)
		ANK 6	170..200		14/37 (38%)
		ANK	204..323	CDD:238125	43/125 (34%)
		ANK repeat	204..236	CDD:293786	9/31 (29%)
		ANK 7	204..234		9/29 (31%)
		Ank_2	209..301	CDD:289560	34/91 (37%)
		ANK repeat	238..268	CDD:293786	14/29 (48%)
		ANK 8	238..267		14/28 (50%)
		ANK repeat	270..301	CDD:293786	11/30 (37%)
		ANK 9	270..299		11/28 (39%)
		Ank_2	275..>331	CDD:289560	16/62 (26%)
		ANK 10	303..332		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..383		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..643
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..729
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	951..975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43734
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24153
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.030