DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment f and ipla-3

DIOPT Version :9

Sequence 1:	NP_001036284.1	Gene:	f / 32718	FlyBaseID:	FBgn0262111	Length:	1918	Species:	Drosophila melanogaster
Sequence 2:	NP_001367163.1	Gene:	ipla-3 / 180354	WormBaseID:	WBGene00012319	Length:	1047	Species:	Caenorhabditis elegans

Alignment Length:	655	Identity:	132/655 - (20%)
Similarity:	221/655 - (33%)	Gaps:	218/655 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 QRFALSENE---SAAYERILLDANAGV------DQHVGYFSKRQVVTSNRESNEELVVDFASETE 235
            ::|.|...|   .|:.|.:..:.||.|      |.|....|:.:.:|.|..::.|   |...:.|
Worm   163 KKFKLVNGEFSVVASLETLTKEMNARVAEQSSPDHHKREDSREERLTKNELTDNE---DPKKKKE 224

  Fly   236 ADEKADEQPEKEEAQYATIAPA------EKGGSAAVPDKESGQVP--CVKCRD------IAIKLR 286
            .|.:|.|:.|.:......:|..      ||...:.....:...|.  |.:||:      :..|..
Worm   225 KDLRAKEEEELKNKPLYHLAITLYNENNEKYVMSLFRSHKLADVVALCERCRENPELFRVFPKNV 289

  Fly   287 TINDYALNSNLH-LSHNTKLNNLH-SNKLLHSNQSHSSSINPSTRMHSHQLDSYLGGVGSMMNLG 349
            .|.|| |::..| |..|....::| |:|:        ..:.....|..|:|..||       ||
Worm   290 NIKDY-LHTIFHELRDNMTWKSVHISSKI--------GLLEYFENMKEHKLKKYL-------NL- 337

  Fly   350 GMGQVGQMYHPGSVSGSERPNGGALALHYAAARGCLDCVQLLVAASVDICYFSTINVKKGLLGRM 414
                   :..|..:|          .|..|.....::.|..::....||...|
Worm   338 -------IVQPEGLS----------PLMIAVQNTQIETVSWMLDHGADINILS------------ 373

  Fly   415 TTSLTSYRRSKQKSKSNNDIHTIIATEVVTAAILSSSVHSSSTGSEIGDGGQGNTSLIEEAAAQD 479
                         |:..|.:| :.||              :|:|..|        .::.|.
Worm   374 -------------SEGQNVLH-VAAT--------------ASSGDLI--------KILWET---- 398

  Fly   480 QSSEEQDRQHQHAKDPLAQTEMNHHPHSHHQRKSAVEVVRQQMDDDGDQDSNDDDETMPMMSGVG 544
                      :..:..:.||:.|.:..::      |.::...:.:            ...:.|.|
Worm   399 ----------KKCETMINQTDSNGYTPAY------VALINACLSN------------CQTLRGFG 435

  Fly   545 RKEQNNRRSVVSANTQMDNDVTPVYLAAQEGHLE---VLKFLVLEAGGSLYVRARDGMAPIHAAS 606
            ...|:      |.:|||.|   |:..|.:.|.|:   :.|.|.|:..|........|...||.|.
Worm   436 GGIQS------SDSTQMAN---PIIGAMKRGKLDEVSLRKMLELKQDGLTETEPTTGNTVIHCAI 491

  Fly   607 QMGCLDCLKWMVQDQ--------------------------------GVDPNLRDGDGATPLHFA 639
            ...||..|....:||                                |||.:.:|.:|.||||.|
Worm   492 NKKCLILLMEKFRDQTDPEARNALQQTPLHTFVIKDELGLVMTLSAYGVDMDAQDINGNTPLHCA 556

  Fly   640 ASRGHLSVVRWLLNHGAKLSL-DKYGKSPINDAA----ENQQVECLNVLVQHGTSV---DYNGKS 696
            .:||:..:.|.||..|||..: ::|.:||.:.||    :..:::.:..|:..|...   .:.|.:
Worm   557 VTRGNTEIARMLLCLGAKPDIKNRYKESPRHIAARLTEKEAKMDIVRALIICGAGACDDGFIGCA 621

  Fly   697 SSQRHKSQQQLHQQHQQQQQQQQQQHLSSSCNS--NSNSSKQTSRSNTIKS--KSSSTLSSDVEP 757
            ....||:.                   .:||.:  .|:||.:.|..:.:|.  .|.:..|:..|
Worm   622 FGCMHKTG-------------------LTSCKTQLGSSSSDEQSMEDRVKDIHVSDNAASAPYE- 666

  Fly   758 FYLHP 762
            |.|.|
Worm   667 FVLDP 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
f	NP_001036284.1	Ank_2	<370..400	CDD:289560	5/29 (17%)
		ANK repeat	371..399	CDD:293786	4/27 (15%)
		ANK	558..684	CDD:238125	44/165 (27%)
		Ank_4	565..618	CDD:290365	15/55 (27%)
		ANK repeat	566..595	CDD:293786	8/31 (26%)
		ANK repeat	597..629	CDD:293786	12/63 (19%)
		Ank_2	602..693	CDD:289560	33/130 (25%)
		ANK repeat	631..660	CDD:293786	14/28 (50%)
		ANK repeat	663..691	CDD:293786	7/34 (21%)
ipla-3	NP_001367163.1	ANK repeat	342..373	CDD:293786	6/40 (15%)
		Ank_2	347..442	CDD:403870	22/180 (12%)
		ANK repeat	375..409	CDD:293786	9/70 (13%)
		ANKYR	<466..614	CDD:223738	38/147 (26%)
		ANK repeat	483..513	CDD:293786	9/29 (31%)
		ANK repeat	517..546	CDD:293786	3/28 (11%)
		Ank_4	518..569	CDD:372654	13/50 (26%)
		ANK repeat	548..579	CDD:293786	14/30 (47%)
		ANK repeat	581..610	CDD:293786	6/28 (21%)
		Pat_PNPLA9	717..1022	CDD:132851
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24153
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030