DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and PRP22

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_010929.3	Gene:	PRP22 / 856732	SGDID:	S000000815	Length:	1145	Species:	Saccharomyces cerevisiae

Alignment Length:	864	Identity:	216/864 - (25%)
Similarity:	393/864 - (45%)	Gaps:	153/864 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AKADAG-------DKLKSEDEKMLRQLVDD------------FLQSCE----PEKQLPGLTKAQR 94
            ||.|.|       :|:.|:.|:..|...|:            ||:..:    .:.::|.:||..|
Yeast   329 AKRDDGSIVNGNTEKVDSKLEEQQRDETDEIDVELNTDDGPKFLKDQQVKGAKKYEMPKITKVPR 393

  Fly    95 SHVHRLAQHRGLKTVSKGPEENRVLFISRPQSDGQQQYILCNTKLDICPPLLDVLGQMAGNVERR 159
            ..::|.|.: |...:....||.     .|.:.:.:||.                          |
Yeast   394 GFMNRSAIN-GSNAIRDHREEK-----LRKKREIEQQI--------------------------R 426

  Fly   160 LMNSVGDLKCNKQQYK-DIRLPSNFGLVGQRLIPPPQSNR-NRNIQH----------ERRSLPIY 212
            ...|..|...||:..: :|::..|     |.::...:.|| |.:|.:          :|::||:|
Yeast   427 KQQSFDDPTKNKKDSRNEIQMLKN-----QLIVTEWEKNRMNESISYGKRTSLPISAQRQTLPVY 486

  Fly   213 KQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERIS 277
            ..|..::..::.:|.|:|.|.|||||:||:.||:.|....:..  .|..:||||:||:||::|::
Yeast   487 AMRSELIQAVRDNQFLVIVGETGSGKTTQITQYLDEEGFSNYG--MIGCTQPRRVAAVSVAKRVA 549

  Fly   278 KERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDT 342
            :|.|...|..|||.||.......:|.:...|.|.|.|...:|.:  ....:.:::||||||.:.|
Yeast   550 EEVGCKVGHDVGYTIRFEDVTGPDTRIKYMTDGMLQREALLDPE--MSKYSVIMLDEAHERTVAT 612

  Fly   343 DFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYM 407
            |.|....|....|.|.|::::.|||::....|.||....::::.|::|.|.:     :.|:|
Yeast   613 DVLFALLKKAAIKRPELKVIVTSATLNSAKFSEYFLNCPIINIPGKTFPVEV-----LYSQT--- 669

  Fly   408 HPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSD 472
             |:|:                        .:...:|     .::::.:.:| .|.::|:|.|..:
Yeast   670 -PQMD------------------------YIEAALD-----CVIDIHINEG-PGDILVFLTGQEE 703

  Fly   473 MTSL-------LARLESSLPREQITIILLHSQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITI 530
            :.|.       :..|..|:  .::.|:.::|.:.:..|.|:|...|....|::.:|||.:|||||
Yeast   704 IDSCCEILYDRVKTLGDSI--GELLILPVYSALPSEIQSKIFEPTPKGSRKVVFATNIAETSITI 766

  Fly   531 PDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNL 595
            ..:.||:|.|.||:..|::.....||.::.||||.|.||.|||||...|.|||||.........|
Yeast   767 DGIYYVVDPGFAKINIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEML 831

  Fly   596 -YTIPEIMRRTLDEICLLTKLAAPDKKIENFLAL-ALDTPPKDAVMQSCSRLKLLGVLDERDEVT 658
             .|:|||.|:.|....|:.|...    |.:.|.. .:|.|||:.::.:.:.|..|..||:..::|
Yeast   832 ENTVPEIQRQNLSHTILMLKAMG----INDLLKFDFMDPPPKNLMLNALTELYHLQSLDDEGKLT 892

  Fly   659 PLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAG 723
            .||..::..|:...:.:.|:.|:..:|.|.::.|.:..||::.|....:|..::..:.::.   .
Yeast   893 NLGKEMSLFPMDPTLSRSLLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSKKAKF---H 954

  Fly   724 DGMSDSLAVIKLYEEFTNLKRKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARL 788
            ....|.|.::.:|..:......:  .:|:.||:....::    .|..::..:..||:  :...:|
Yeast   955 HPYGDHLTLLNVYTRWQQANYSE--QYCKTNFLHFRHLK----RARDVKSQISMIFK--KIGLKL 1011

  Fly   789 ASSFNNDTNMIRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWIL 853
            .|. ::|.::||....:|.:...|..|.:...:.: .|...|.:..||.|.||:      .|:::
Yeast  1012 ISC-HSDPDLIRKTFVSGFFMNAAKRDSQVGYKTI-NGGTEVGIHPSSSLYGKE------YEYVM 1068

  Fly   854 FVEKTRTA----DQISSLE 868
            :.....|:    .|::|:|
Yeast  1069 YHSIVLTSREYMSQVTSIE 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	14/74 (19%)
		DEXDc	214..395	CDD:214692	61/180 (34%)
		DEXDc	226..368	CDD:238005	53/141 (38%)
		HELICc	479..575	CDD:197757	36/95 (38%)
		HA2	648..733	CDD:214852	18/84 (21%)
		OB_NTP_bind	783..884	CDD:285018	20/90 (22%)
PRP22	NP_010929.3	Pnp	1..423	CDD:224106	21/99 (21%)
PRP22	NP_010929.3	HrpA	456..1145	CDD:224557	185/700 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810