DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and ECM16

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_013847.1	Gene:	ECM16 / 855158	SGDID:	S000004735	Length:	1267	Species:	Saccharomyces cerevisiae

Alignment Length:	746	Identity:	199/746 - (26%)
Similarity:	341/746 - (45%)	Gaps:	161/746 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 NRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILE--WAAEHRA--PV 257
            :|:..||..|..||::.:...|:..:..:.|:||.|.|||||:||:||::.|  :.||...  |.
Yeast   379 SRSDEIQKARIQLPVFGEEHKIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGFGAEDSPDYPG 443

  Fly   258 RIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKS 322
            .:.::||||:||:|::||::.|.|: .|..|||.||.:.....:|.:...|.|.|||.:..|
Yeast   444 MVGITQPRRVAAVSMAERVANELGD-HGHKVGYQIRFDSTAKEDTKVKFMTDGVLLREMMHD--- 504

  Fly   323 FFKNTTH--LIIDEAHERDLDTDFLL--------LATKLELQKNP----HLRLVLMSATMDLEAL 373
             ||.|.:  :||||||||:::||.|:        |..||. ::||    .|:|::||||:   .:
Yeast   505 -FKLTKYSSIIIDEAHERNINTDILIGMLSRCVRLRAKLH-KENPIEHKKLKLIIMSATL---RV 564

  Fly   374 SNYFGGGT-------VMDVEGRSFEVSIY--------HLEDILSKTGYMHPRM------------ 411
            |::....|       |:.|:.|.|.|||:        :.::...||..:|.::
Yeast   565 SDFSENKTLFPIAPPVLQVDARQFPVSIHFNRRTAFNYTDEAFRKTCKIHQKLPPGAILVFLTGQ 629

  Fly   412 -----------EKFLGKPTGK-----ETPSELLAAYYGGNTIVHPD-------IDNDLIVSLLEL 453
                       ::|..|...|     |||...:........:...|       ||.|...|.:..
Yeast   630 QEITHMVKRLRKEFPFKKNSKYNKDLETPVSKMGINSKTTDLEAEDIDFSVQVIDQDKFKSAIRY 694

  Fly   454 LLRQGDAG----AVIVYLPGYSDMTSLLARLESSLPREQITIILLHSQVDNSEQRKVFRTYP-GV 513
            ...:|::|    .......|:.::.:     |.....:.:.::.|:|.:...||.:||:..| |.
Yeast   695 EEDEGNSGNGEDEEDEEEEGFEEVLT-----EGQTANDPLYVLPLYSLLPTKEQMRVFQKPPQGS 754

  Fly   514 RLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCH 578
            || .|::||:.:||:|||.:.||:|:|.:|.:.|:.:.......:.|:|:|.|.||:|||||...
Yeast   755 RL-CIVATNVAETSLTIPGVRYVVDSGRSKERKYNESNGVQSFEVGWVSKASANQRSGRAGRTGP 818

  Fly   579 GNCYRLY-----DNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLALALDTPP-KDA 637
            |:|||||     ::|    ...::.|||:|..::.|.|..|..|    |.|.:.....||| :.|
Yeast   819 GHCYRLYSSAVFEHD----FEQFSKPEILRMPVESIVLQMKSMA----IHNIINFPFPTPPDRVA 875

  Fly   638 VMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPF 702
            :.::...|:.||.||.::.:|..|..::..||..:..|.|:.|....||..::.|.:..||.|||
Yeast   876 LSKAIQLLQYLGALDNKEMITEDGKKMSLFPLSPRFSKMLLVSDEKACLPYIVAIVSALSVGDPF 940

  Fly   703 VLNIERG----------------------------------------KKSGQQISRVLFAGDGMS 727
            :...|.|                                        .||..|.|::    |..|
Yeast   941 INEFELGINEISRKPNPDENLDDKIREHDESTPGMDPELKKELRSKFYKSRSQFSKL----DKFS 1001

  Fly   728 DSLAVIKLYE--EFTNLKRKDIGDFCERNFICRNAME---------MFVSAASTLRDTVYRIFRF 781
            |...::.:..  ::...::|:|  |.::||:....||         |::..::|.::.:..:.|.
Yeast  1002 DVFRLLSVVSAMDYVPKEQKEI--FMKKNFLRGKLMEEIVKLRKQLMYIIKSNTSKENIAVVIRN 1064

  Fly   782 SEASARLASSFNNDTNMIRLALTAGLYPKLA 812
            .:..:.:.|..  ...:::..:.||....:|
Yeast  1065 EDLKSDIPSVI--QIKLLKQMICAGFVDHVA 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	75/205 (37%)
		DEXDc	226..368	CDD:238005	65/159 (41%)
		HELICc	479..575	CDD:197757	34/96 (35%)
		HA2	648..733	CDD:214852	28/124 (23%)
		OB_NTP_bind	783..884	CDD:285018	4/30 (13%)
ECM16	NP_013847.1	HrpA	360..1267	CDD:224557	199/746 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810