DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and PRP16

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_013012.3	Gene:	PRP16 / 853961	SGDID:	S000001794	Length:	1071	Species:	Saccharomyces cerevisiae

Alignment Length:	871	Identity:	232/871 - (26%)
Similarity:	377/871 - (43%)	Gaps:	171/871 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MPEQAVVLVVNGRVTGGPKGTGKQKTRPGKNAKADAGDKLKSEDE------KMLRQLVDDFLQSC 80
            :||:|.:|.|...:                    |..|.|::..:      |...:.:..||...
Yeast   192 LPEEAKLLPVIRNI--------------------DNDDALRNTVQLYPIPLKQRMEWIPPFLSKF 236

  Fly    81 EPEKQLP-----GLTKAQRSHVHRLAQ---------------HRGLKTVSKGPEENRVLFISRPQ 125
            ..|.::|     |......|.|..|:.               .||.|.|:          :.|..
Yeast   237 ALENKVPTSIIIGSISETSSQVSALSMVNPFRNPDSEFSANAKRGSKLVA----------LRRIN 291

  Fly   126 SDGQQQYILCNTKLDICPPLLDVLGQMAGNVERRLMNSVGDLKCNKQQYKDIRLPSNFGLVGQRL 190
            .:..||      ..|....|...:|::.|     |.|:      ||.:.|     ||..:.....
Yeast   292 MEHIQQ------SRDNTTVLNTAMGEVLG-----LENN------NKAKDK-----SNQKICDDTA 334

  Fly   191 IPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRA 255
            :..|..:   :|:|.:..||:::.|..:|::::.:||::|.|.|||||:|||.||:.|....:..
Yeast   335 LFTPSKD---DIKHTKEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDR 396

  Fly   256 PVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSN-TVLMLTTSGCLLRALAMD 319
            ...|||:||||:|||||::|::.|.....|..|||:||......|. |.|...|.|.|||...:|
Yeast   397 GKSIVVTQPRRVAAISVAKRVAMEMQVPLGKEVGYSIRFEDVTDSECTKLKFVTDGILLRETLLD 461

  Fly   320 KKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMD 384
              ......:.:||||||||.|:||.||...|:.|.:...|:|::.||||:.:..|.:||......
Yeast   462 --DTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMNAKKFSAFFGNAPQFT 524

  Fly   385 VEGRSFEV-SIY-------HLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPD 441
            :.||:|.| :||       ::|..:|:...:|
Yeast   525 IPGRTFPVQTIYTSNPVQDYVEAAVSQAVKIH--------------------------------- 556

  Fly   442 IDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPR--------------EQITII 492
            :.||.            .:|.:::::.|..|:.:....|:....:              ..|.|:
Yeast   557 LANDC------------SSGDILIFMTGQEDIETTFDTLQEKFLQVYSKKFGTANFEEINDIEIL 609

  Fly   493 LLHSQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLT 557
            .::|.:....|.|:|:...|.:.|||::|||.:||:||..:.||||.|.:|:|.|:..|....|.
Yeast   610 PIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKIGLDSLV 674

  Fly   558 LTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMAR-MNLYTIPEIMRRTLDEICLLTKLAAPDKK 621
            :|.||:|:|.||:|||||...|..||||..|.... |.|.|||||.|..|....||.|......:
Yeast   675 ITPISKANADQRSGRAGRTAPGTAYRLYTEDTFKEDMYLQTIPEIQRTNLSNTLLLLKSLDVTDE 739

  Fly   622 IENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCL 686
            :..|  ..:|.||....:.|...|..:|.:|...::||||..:|:.||...:.|.|:.::...|.
Yeast   740 LSKF--PFIDKPPLQTFLSSLYELWFIGAIDTSGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCS 802

  Fly   687 DSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEF--TNLKRKDIGD 749
            |.|:.|.:..||...|....||.|::....::...|   .||.|.::.::|::  .|..    ..
Yeast   803 DEMLTIVSMLSVPQVFYRPKERQKEADIARNKFFIA---KSDHLTLLNVFEQWRANNFS----SH 860

  Fly   750 FCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYM 814
            :|.::|:...::    ..|..:||.:..|.:..:..   ..|...|.::|:..:.:|...:.|.:
Yeast   861 WCNKHFVQYKSL----VRARDIRDQLLTILKSQKIP---VISSGKDWDIIKKCICSGFAHQAAKI 918

  Fly   815 DRENKNQLVAEGDPLVQVSRSSCLRG 840
             ...:|.:..:....||:..:|.|.|
Yeast   919 -TGLRNYVHLKTGVSVQLHPTSALHG 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	13/84 (15%)
		DEXDc	214..395	CDD:214692	74/182 (41%)
		DEXDc	226..368	CDD:238005	63/142 (44%)
		HELICc	479..575	CDD:197757	38/109 (35%)
		HA2	648..733	CDD:214852	25/84 (30%)
		OB_NTP_bind	783..884	CDD:285018	11/58 (19%)
PRP16	NP_013012.3	HrpA	319..1071	CDD:224557	202/697 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810