DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and DHR2

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_012845.1	Gene:	DHR2 / 853784	SGDID:	S000001561	Length:	735	Species:	Saccharomyces cerevisiae

Alignment Length:	808	Identity:	210/808 - (25%)
Similarity:	363/808 - (44%)	Gaps:	167/808 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 VGDLKCNKQQ---YKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRD 225
            |.|.:.||:.   ||.::                  :|..::...|.:||:|:.:..|::.::.:
Yeast    51 VSDQRSNKENVLTYKSLK------------------SRASDLLKMRETLPVYQHKREIMSYIESN 97

  Fly   226 QVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGY 290
            .|.::.|.||||||||:||::||...:.:....|.|:||||:|||:::.|:::|.|...|..|||
Yeast    98 PVTVLIGETGSGKSTQIPQFVLEKLYDTKKHGSIAVTQPRRVAAINLATRVAQEHGCKLGEQVGY 162

  Fly   291 NIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQ- 354
            ::|.:...::.|.|...|.|.|||.|.|:  |..:..:.::|||||||.:.||.:|...|..:|
Yeast   163 SVRFDNTTTTRTRLKYLTDGMLLRELMMN--SDLREYSVIVIDEAHERTVLTDLILGFLKSLIQG 225

  Fly   355 KNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPT 419
            ..|.||:::||||:..|..|.:|....::.||||.|:|..|:|:                  .||
Yeast   226 PRPDLRIIVMSATLQAEKFSEFFNNAPILFVEGRKFDVKQYYLK------------------APT 272

  Fly   420 GKETPSELLAAYYGGNTIVHPDIDNDLIVSLLE--LLLRQG-DAGAVIVYLPGYSDMTSLLARLE 481
                                    :|::.:::.  :.:.|| :.|.::.:|||..::...:..:|
Yeast   273 ------------------------DDIVDAVIRCCIQINQGEELGDILCFLPGQEEIDKAVTIME 313

  Fly   482 -------SSLPREQITIILLHSQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDT 539
                   ...|...|....|::.:...:|..||....|.:.|::.||||.:||:||..:.:|:|:
Yeast   314 KIAKYVSDEAPVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKVVFSTNIAETSVTISGVKFVVDS 378

  Fly   540 GLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRR 604
            ||.|:|.:...:..:.|....||||.|.||:|||||...|..:|||......::...:.|||.|.
Yeast   379 GLRKVKVWRHQLGLATLLTVPISQASAMQRSGRAGRESEGKSFRLYCESDYVKLPKQSEPEIARS 443

  Fly   605 TLDEICLLTKLAAPDKKI-----ENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIV 664
            .:....|:.|....|..:     ||        |.|:|::.....|..||.||.|.::|..|..:
Yeast   444 DVTSPVLMLKRYGVDDLLNWTWFEN--------PGKEAIVMGLQELYELGALDTRGKITKRGQQM 500

  Fly   665 AELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLN---IERGKKSGQQISRVLFAGDGM 726
            |.|||...:...|:.:..:.||..:|.|.:..||.: .:||   .||.:.:.:::| :..||...
Yeast   501 ALLPLQPHLSSVLIKASEVGCLSQVIDIVSCLSVEN-LLLNPSPEERDEVNERRLS-LCNAGKRY 563

  Fly   727 SDSLAVIKLYE-EFTNL-KRKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLA 789
            .|.:.:.:|:: .|..| |.:|...  |||..|:.                            |.
Yeast   564 GDLIMLKELFDIYFYELGKSQDASS--ERNDWCKG----------------------------LC 598

  Fly   790 SSFNNDTNMIRL-----ALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLAS 849
            .|.....|:||:     .....|:..::..|.|:|.  :.|...|:.......|.|
Yeast   599 ISIRGFKNVIRVRDQLRVYCKRLFSSISEEDEESKK--IGEDGELISKILKCFLTG--------- 652

  Fly   850 EWILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAEFGLQ 914
                |::  .||..:....:.|:.:|..:::          |.|.||     ::...||   |:
Yeast   653 ----FIK--NTAIGMPDRSYRTVSTGEPISI----------HPSSML-----FMNKSCP---GI- 692

  Fly   915 LHKVRMLTDREFAKLVATRKLSLMSDFI 942
            ::...:.|.:.:|:.|:..:||.:.:.:
Yeast   693 MYTEYVFTTKGYARNVSRIELSWLQEVV 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	70/181 (39%)
		DEXDc	226..368	CDD:238005	59/142 (42%)
		HELICc	479..575	CDD:197757	34/102 (33%)
		HA2	648..733	CDD:214852	26/87 (30%)
		OB_NTP_bind	783..884	CDD:285018	18/105 (17%)
DHR2	NP_012845.1	HrpA	30..730	CDD:224557	210/808 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810