DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and YLR419W

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_013523.3	Gene:	YLR419W / 851137	SGDID:	S000004411	Length:	1435	Species:	Saccharomyces cerevisiae

Alignment Length:	819	Identity:	234/819 - (28%)
Similarity:	401/819 - (48%)	Gaps:	118/819 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 QSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHR---AP 256
            :|:..:::|..|..||.:|:::.|::::.:::|::|.|.||||||||:.|:||::..:.:   ..
Yeast   590 KSSEYKSMQLVREQLPAWKKQKVIIDIINKNEVVLITGETGSGKSTQVVQFILDFLQKEKGDFGK 654

  Fly   257 VRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKK 321
            .:||.:|||||:||.::||:|.||....|..|||.||...:..::|.:...|:|.|:| |..:.:
Yeast   655 TKIVCTQPRRISAIGLAERVSDERCVTCGEEVGYVIRGVNKTKASTRIKFMTTGVLVR-LLQNAR 718

  Fly   322 SFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVE 386
            :..:||. ::|||.|||.:|||.::...|..|.:...:::||||||::::....:|.|.....:|
Yeast   719 TMLENTI-VVIDEVHERSIDTDLIVTLMKNLLHRVRGMKIVLMSATVNVDLFKKFFPGLATCHIE 782

  Fly   387 GRSFEVSIYHLEDILSKTGYMHPRMEKFLG----KPTGKETPSELLAAYYGGNTIVHPDIDNDLI 447
            ||:|.::.|.||||||...:...| ||.|.    ....:....:.|.............|:.||:
Yeast   783 GRTFPITDYFLEDILSDLDFKIKR-EKALSYDDDSVDERNNDDQYLKPRADSKFFTSGQINYDLL 846

  Fly   448 VSLLELLLRQ----GDAGAVIVYLPGYSDMTSLLARLESSLPREQITIILLHSQVDNSEQRKVFR 508
            ..::|.:.::    .|.|::||:|||..::......|.:........::.|||.:...:|::||:
Yeast   847 CQVVEYVHKRLKAANDNGSIIVFLPGVGEINKCCNLLANKSNEADFMVLPLHSALTPEDQKRVFK 911

  Fly   509 TYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRA 573
            .|.|.| |:::||||.:|||||.|.:..||||.||...|:...:.::|..::||:|:.|||.|||
Yeast   912 KYHGKR-KVVVSTNIAETSITIDDCVATIDTGRAKSMFYNPKDNTTKLIESFISKAEVKQRRGRA 975

  Fly   574 GRVCHGNCYR-----LYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLALALDTP 633
            |||..|..|:     ||:||.::    ..||||.|..|:.:.|..| |...|.::.||:.|||.|
Yeast   976 GRVREGLSYKLFSKNLYENDMIS----MPIPEIKRIPLESLYLSVK-AMGIKDVKAFLSTALDAP 1035

  Fly   634 PKDAVMQSCSRLKLLGVLDERDE-VTPLGHIVAELP-LGVQIGKCLVYSIYLRCLDSMIIIAAYH 696
            |..|:.::...|..:|::||.|: :|.||..::.:| :..:.||.|:|.|...|.|..:::.:..
Yeast  1036 PLPALQKAERILTTIGLVDESDKSLTQLGQFISLMPVMDSKHGKLLIYGILFGCTDISVLLVSIL 1100

  Fly   697 SVRD-PFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEF-----TNLKRKDIGDFCERNF 755
            .:.. ||:...|..:|    |.::|...:...|..||:::..::     :::|||.:.|    |.
Yeast  1101 GIGVLPFIGGFENREK----IKKLLCKYESRGDLFAVLEIVRDYFKIKDSSIKRKYLRD----NL 1157

  Fly   756 ICRNAMEMFVSAA----STLRDT-----VYRIFRFSEASARLASSFNNDTN--MIRLALTAGLYP 809
            :..|.:....|:.    |.|:|.     .|::...|:.:       .|:.|  ::|..||...||
Yeast  1158 LSYNKINEIKSSTAQYYSILKDVGFLPMDYKVGSISDLN-------RNERNFDILRAILTGAFYP 1215

  Fly   810 KLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVE--------KTRTADQISS 866
            .:|.:...:...|          |.||....|..:..:...||...|        ||:.:.:...
Yeast  1216 HIARVQLPDVKYL----------STSSGAVEKDPEAKMIKYWIRSEEYQDKLEEYKTKISQETQK 1270

  Fly   867 LEHTTLVSGLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAEFGLQLHKVRMLTDRE------ 925
            ::...|      .|...:.||   |.|.:|...:|           :.|...::|::.:
Yeast  1271 VDLEDL------PLPATRAFI---HPSSVLFSTNS-----------VNLEDAKLLSEVDGPISRQ 1315

  Fly   926 -------------FAKLVATRKLSLMSDFIGPETVRRLL 951
                         |.....|.||.|..  :.|.|...||
Yeast  1316 SKIPTVVKYPFVLFTTSQVTNKLYLRD--LTPTTTLSLL 1352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	66/183 (36%)
		DEXDc	226..368	CDD:238005	58/144 (40%)
		HELICc	479..575	CDD:197757	38/95 (40%)
		HA2	648..733	CDD:214852	23/87 (26%)
		OB_NTP_bind	783..884	CDD:285018	20/110 (18%)
YLR419W	NP_013523.3	UBA_YLR419W_like	369..409	CDD:270457
		RWD	426..528	CDD:399058
		HrpA	563..1428	CDD:224557	234/819 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910