DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and HVT1

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_850154.2	Gene:	HVT1 / 817631	AraportID:	AT2G30800	Length:	1299	Species:	Arabidopsis thaliana

Alignment Length:	1081	Identity:	315/1081 - (29%)
Similarity:	491/1081 - (45%)	Gaps:	218/1081 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GKQKTRPGKNAKADAGDKLKSEDEKM-LRQLVDDFLQSCEPEKQLP-GLTKAQRSHVHRLAQHRG 105
            |.::.|...|    ||.....|..:: ..::::||..|........ .|:..:|..:|::.:..|
plant     2 GNKRFRSDNN----AGKPTSVEATRIWATKVIEDFRASGNEVYTFEHNLSNNERGVIHQMCRKMG 62

  Fly   106 LKTVSKGPEENRVL--FISRPQSDGQQQYILCNTKLD----IC---PPLLDVLGQ--------MA 153
            :::.|.|..|.|.|  |.||.::..:.:   .|.|.:    .|   ||..||:.|        ..
plant    63 IQSKSSGRGEQRRLSIFKSRHKNGNKNE---ANEKSNKEKLKCVSFPPGADVILQELFTHYPPCD 124

  Fly   154 GNVERRLMNSVGDLKCNKQQYKD--IRLPSNFGLVGQRLIPPPQSNRNR--------NIQHERRS 208
            |:............|..:.|:||  .|.|.   :..:.::....|..:|        .|...|..
plant   125 GDTAATSFTKYSGNKGKQGQWKDDFFRKPQ---ISSEEILEKVASLSSRLKKDKALKEITKLRSK 186

  Fly   209 LPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILE--WAAEHRAPVRIVVSQPRRIAAIS 271
            |||...:::|.:.::.:||::|.|.||.||:||:|||:|:  |::: |...:||.:|||||:|:|
plant   187 LPITSFKDAITSAVESNQVILISGETGCGKTTQVPQYLLDHMWSSK-RETCKIVCTQPRRISAMS 250

  Fly   272 VSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRAL-AMDKKSFFKNTTHLIIDEA 335
            ||||||.||||:.|..:||.:|:..:...::.::..|:|.|||.| .....|...:.||:|:||.
plant   251 VSERISCERGESIGENIGYKVRLQSKGGRHSSVVFCTNGILLRVLVGKGSVSSVSDITHIIVDEI 315

  Fly   336 HERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDI 400
            ||||..:||:|...:..|..||||||:|||||:|.|..|.||||..|:.|.|.::.|...:|||:
plant   316 HERDCYSDFMLAIIRDLLPSNPHLRLILMSATLDAERFSGYFGGCPVVRVPGFTYPVRTLYLEDV 380

  Fly   401 LS--KTG---------------------------------------------------------Y 406
            ||  |:|                                                         |
plant   381 LSILKSGGDNHLSSTNLSISDHKLDLTDEDKLALDEAIILAWTNDEFDALLDLVSSRGSHEIYNY 445

  Fly   407 MH------PRMEKFLGKPTGK----------------------------ETPSELLAAYYGGNTI 437
            .|      |.| .|.||  |:                            |..::|.||     .|
plant   446 QHQSTWLTPLM-VFAGK--GRISDVCMLLSFGADWSLKSKDGMTALELAEAENQLEAA-----QI 502

  Fly   438 VHPDIDN----------------------DLIVSLLELLLRQ--GDA--GAVIVYLPGYSDMTSL 476
            :....||                      .:.|||::.|:|:  ||:  ||::|:|||:.|:...
plant   503 IREHADNSQSNSQQGQQLLDKYMATINPEQVDVSLIQQLMRKICGDSEDGAILVFLPGWDDINKT 567

  Fly   477 LARLESS---LPREQITIILLHSQVDNSEQRKVF-RTYPGVRLKIILSTNIGQTSITIPDLLYVI 537
            ..||..:   ....:..||.|||.|...||:||| |..||.| ||:|:|||.::::||.|::|||
plant   568 RQRLLENPFFADSAKFDIICLHSMVPAGEQKKVFNRPPPGCR-KIVLATNIAESAVTIDDVVYVI 631

  Fly   538 DTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIM 602
            |:|..|.|:||...:.|.|..:|:|:|:||||.|||||...|.||.||...|.|.|..:.:|||.
plant   632 DSGRMKEKSYDPYNNVSTLQSSWVSKANAKQRQGRAGRCQPGICYHLYSRLRAASMPDFKVPEIK 696

  Fly   603 RRTLDEICLLTKLAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAEL 667
            |..::|:||..|:..|:.|..:||...||.|...::..:.|.|:.:|.|..::|:|.||.....|
plant   697 RMPVEELCLQVKILDPNCKTNDFLQKLLDPPVDQSIANALSILQDIGALTPQEELTELGEKFGHL 761

  Fly   668 PLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVL---NIERGKKSGQQISRVLFAGDGMSDS 729
            |:...|.|.|.:::.:.|||..:.:|.....::||.:   .:||.|.:..::......| |.||.
plant   762 PVHPLISKMLFFAVLVNCLDPALTLACAADYKEPFTMPMSPVERQKAAAAKLELASLCG-GDSDH 825

  Fly   730 LAVIKLYEEFTNLKRKDI-GDFCERNFICRNAMEMFVSAASTLRDTVYR--IFRFSEASARLASS 791
            |||:..:|.:.|.|.:.: .:||.:.|:..:||:|.....|.|...:.|  |.....:|   .|.
plant   826 LAVVAAFECWKNAKGRGLSAEFCSQYFVSPSAMKMLDQMRSQLESELKRHGIIPNDISS---CSQ 887

  Fly   792 FNNDTNMIRLALTAGLYP---KLAYMDRENKNQLV--AEGDP--LVQVSRSSCLRGKKKQKDLAS 849
            .:.|..::|..|..||||   :|......|:..:|  |.|..  :..:|.:..|..||..:.|
plant   888 NSRDPGILRAVLAVGLYPMVGRLCPAFGNNRRTIVETASGAKVRVHSLSNNFNLSSKKYDESL-- 950

  Fly   850 EWILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFIT-------------EAHGSEMLLCLDS 901
              ::|.|.|| .|....:.:.|:...|.:.|...:..:.             |....|:....:.
plant   951 --LVFDEITR-GDGGMHIRNCTVARDLPLLLISTEIAVAPTGSSDSDDSNEEEEDDEEVAANTNE 1012

  Fly   902 WIRLKCPAEFGLQLHK------VRMLTDRE-FAKLVATRKL 935
            .:......| |:.:||      .:|::..| ..|||..|.|
plant  1013 EVAANTNEE-GMDIHKEESRRGAKMMSSPENSVKLVVDRWL 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	14/62 (23%)
		DEXDc	214..395	CDD:214692	82/183 (45%)
		DEXDc	226..368	CDD:238005	69/144 (48%)
		HELICc	479..575	CDD:197757	47/99 (47%)
		HA2	648..733	CDD:214852	26/87 (30%)
		OB_NTP_bind	783..884	CDD:285018	27/107 (25%)
HVT1	NP_850154.2	R3H_DEXH_helicase	22..80	CDD:100077	12/57 (21%)
		HrpA	153..>946	CDD:224557	257/809 (32%)
		ANK repeat	417..444	CDD:293786	0/26 (0%)
		ANK repeat	446..481	CDD:293786	7/37 (19%)
		PTZ00322	453..>506	CDD:140343	11/60 (18%)
		ANK repeat	483..507	CDD:293786	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	51	1.000	Domainoid score	I4329
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106429
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3857
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.720