Protein Alignment CG8915 and DHX40

DIOPT Version :10

• Sequence 1: NP_573208.1
• Gene: CG8915 / 32715
• FlyBaseID: FBgn0030833
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_078888.4
• Gene: DHX40 / 79665
• HGNCID: 18018
• Length: 779
• Species: Homo sapiens
• Alignment Length: 859
• Identity: 229/859 - (26%)
• Similarity: 385/859 - (44%)
• Gaps: 174/859 - (20%)

  Fly   178 RLPSNFGLVGQRLIPPPQSNRNRNIQHERRS----------------------LPIYKQRESILN 220
            |.|:..|...:|   ..:..|:|::|.||.|                      .||.|||:.|:.
Human     3 RFPAVAGRAPRR---QEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQ 64

  Fly   221 VLQRDQVLIIKGATGSGKSTQLPQYILEWA-AEHRAPVRIVVSQPRRIAAISVSERISKERGEAP 284
            .::.:..||:.|.|||||:||||:|:.|.. ::|.   .|.|:|||::|||||::|:::|.....
Human    65 AVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHG---MIGVTQPRKVAAISVAQRVAEEMKCTL 126

  Fly   285 GTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTH---LIIDEAHERDLDTDFLL 346
            |:.|||.:|.:...|..|.:...|.||||:.:..|     .|.|.   :|:||||||.|.||.|.
Human   127 GSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGD-----PNLTKFSVIILDEAHERTLTTDILF 186

  Fly   347 -LATKLELQKNP----HLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGY 406
             |..||..:|:|    ||::|:|||||:|..||.:||...:.|:.||
Human   187 GLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGR------------------ 233

  Fly   407 MHPRMEKF--LGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPG 469
            ::|..|||  |..|..:|..:.:.|       ||...:|    :.|.|:      ||.::|:|.|
Human   234 LYPVREKFCNLIGPRDRENTAYIQA-------IVKVTMD----IHLNEM------AGDILVFLTG 281

  Fly   470 YSDM---TSLLARLESSLPREQ---------ITIILLHSQVDNSEQRKVF-RTYPGVRLKIILST 521
            ..::   ..||.::..|:..:.         :.|:..:..:...:||::| ...||:| |.::||
Human   282 QFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIR-KCVIST 345

  Fly   522 NIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYD 586
            ||..||:||..:.||:|.|..|...::..:....|.:..||:::|.||:|||||...|.|:|:|.
Human   346 NISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYS 410

  Fly   587 NDRMAR-MNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLALA-LDTPPKDAVMQSCSRLKLLG 649
            .|...: |..:.||||.|.:|..:.|..|..|    |.:.:... ||.|.:..::::..:|....
Human   411 KDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLA----IHDVIRFPYLDPPNERLILEALKQLYQCD 471

  Fly   650 VLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIE-RGKKSG 713
            .:|....||.||..:.|.||...:...::.:..|.|.|.::.|||..||.:.|:..:: ..:|..
Human   472 AIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEA 536

  Fly   714 QQISRVLFA-GDGMSDSLAVIKLYEEFTNLKRKDIG---DFCERNFICRNAMEMFVSAASTLRDT 774
            :|..|.|.| ..|.:|...:..::|:.     |..|   .:|::::|....:.......:.||:.
Human   537 EQRHRELAAKAGGFNDFATLAVIFEQC-----KSSGAPASWCQKHWIHWRCLFSAFRVEAQLREL 596

  Fly   775 VYRIFRFSEASARLASSFNNDT------NMIRLALTAGLYPKLAYMDRENKNQ----LVAEGDPL 829
            :.::        :..|.|..:|      .::|..|.||.:..:|   |.:..:    :...|.|
Human   597 IRKL--------KQQSDFPKETFEGPKHEVLRRCLCAGYFKNVA---RRSVGRTFCTMDGRGSP- 649

  Fly   830 VQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGSE 894
            |.:..||.|.    :::...|||:|              |..||:             |:.:...
Human   650 VHIHPSSALH----EQETKLEWIIF--------------HEVLVT-------------TKVYARI 683

  Fly   895 MLLCLDSWIRLKCPAEFGLQLHKVRMLTDREFAKLVATR-----KLSLMSDFIGPETVRRLLEAD 954
            :......|:|...|.......|.:..:..||..:....|     .:..:.|.|..:.::::...:
Human   684 VCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDVLKKMQRRN 748

  Fly   955 VPSTCLAEGKSLLD 968
                   :.||:.|
Human   749 -------DDKSISD 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_573208.1	R3H	67..123	CDD:460206
		HrpA	208..>702	CDD:441249	170/541 (31%)
		OB_NTP_bind	799..884	CDD:400182	19/88 (22%)
DHX40	NP_078888.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		7/27 (26%)
		HrpA	51..>724	CDD:441249	214/768 (28%)
		DEAH box	173..176		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..779		3/26 (12%)