DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and DHX40

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_078888.4	Gene:	DHX40 / 79665	HGNCID:	18018	Length:	779	Species:	Homo sapiens

Alignment Length:	859	Identity:	229/859 - (26%)
Similarity:	385/859 - (44%)	Gaps:	174/859 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 RLPSNFGLVGQRLIPPPQSNRNRNIQHERRS----------------------LPIYKQRESILN 220
            |.|:..|...:|   ..:..|:|::|.||.|                      .||.|||:.|:.
Human     3 RFPAVAGRAPRR---QEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQ 64

  Fly   221 VLQRDQVLIIKGATGSGKSTQLPQYILEWA-AEHRAPVRIVVSQPRRIAAISVSERISKERGEAP 284
            .::.:..||:.|.|||||:||||:|:.|.. ::|.   .|.|:|||::|||||::|:::|.....
Human    65 AVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHG---MIGVTQPRKVAAISVAQRVAEEMKCTL 126

  Fly   285 GTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTH---LIIDEAHERDLDTDFLL 346
            |:.|||.:|.:...|..|.:...|.||||:.:..|     .|.|.   :|:||||||.|.||.|.
Human   127 GSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGD-----PNLTKFSVIILDEAHERTLTTDILF 186

  Fly   347 -LATKLELQKNP----HLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGY 406
             |..||..:|:|    ||::|:|||||:|..||.:||...:.|:.||
Human   187 GLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGR------------------ 233

  Fly   407 MHPRMEKF--LGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPG 469
            ::|..|||  |..|..:|..:.:.|       ||...:|    :.|.|:      ||.::|:|.|
Human   234 LYPVREKFCNLIGPRDRENTAYIQA-------IVKVTMD----IHLNEM------AGDILVFLTG 281

  Fly   470 YSDM---TSLLARLESSLPREQ---------ITIILLHSQVDNSEQRKVF-RTYPGVRLKIILST 521
            ..::   ..||.::..|:..:.         :.|:..:..:...:||::| ...||:| |.::||
Human   282 QFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIR-KCVIST 345

  Fly   522 NIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYD 586
            ||..||:||..:.||:|.|..|...::..:....|.:..||:::|.||:|||||...|.|:|:|.
Human   346 NISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYS 410

  Fly   587 NDRMAR-MNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLALA-LDTPPKDAVMQSCSRLKLLG 649
            .|...: |..:.||||.|.:|..:.|..|..|    |.:.:... ||.|.:..::::..:|....
Human   411 KDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLA----IHDVIRFPYLDPPNERLILEALKQLYQCD 471

  Fly   650 VLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIE-RGKKSG 713
            .:|....||.||..:.|.||...:...::.:..|.|.|.::.|||..||.:.|:..:: ..:|..
Human   472 AIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEA 536

  Fly   714 QQISRVLFA-GDGMSDSLAVIKLYEEFTNLKRKDIG---DFCERNFICRNAMEMFVSAASTLRDT 774
            :|..|.|.| ..|.:|...:..::|:.     |..|   .:|::::|....:.......:.||:.
Human   537 EQRHRELAAKAGGFNDFATLAVIFEQC-----KSSGAPASWCQKHWIHWRCLFSAFRVEAQLREL 596

  Fly   775 VYRIFRFSEASARLASSFNNDT------NMIRLALTAGLYPKLAYMDRENKNQ----LVAEGDPL 829
            :.::        :..|.|..:|      .::|..|.||.:..:|   |.:..:    :...|.|
Human   597 IRKL--------KQQSDFPKETFEGPKHEVLRRCLCAGYFKNVA---RRSVGRTFCTMDGRGSP- 649

  Fly   830 VQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGSE 894
            |.:..||.|.    :::...|||:|              |..||:             |:.:...
Human   650 VHIHPSSALH----EQETKLEWIIF--------------HEVLVT-------------TKVYARI 683

  Fly   895 MLLCLDSWIRLKCPAEFGLQLHKVRMLTDREFAKLVATR-----KLSLMSDFIGPETVRRLLEAD 954
            :......|:|...|.......|.:..:..||..:....|     .:..:.|.|..:.::::...:
Human   684 VCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDVLKKMQRRN 748

  Fly   955 VPSTCLAEGKSLLD 968
                   :.||:.|
Human   749 -------DDKSISD 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	77/189 (41%)
		DEXDc	226..368	CDD:238005	64/150 (43%)
		HELICc	479..575	CDD:197757	31/105 (30%)
		HA2	648..733	CDD:214852	24/86 (28%)
		OB_NTP_bind	783..884	CDD:285018	22/110 (20%)
DHX40	NP_078888.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		7/27 (26%)
		HrpA	16..770	CDD:224557	225/843 (27%)
		DEAH box	173..176		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..779		3/26 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810