Protein Alignment CG8915 and ythdc2

DIOPT Version :10

• Sequence 1: NP_573208.1
• Gene: CG8915 / 32715
• FlyBaseID: FBgn0030833
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_004910524.1
• Gene: ythdc2 / 779469
• XenbaseID: XB-GENE-5881731
• Length: 1457
• Species: Xenopus tropicalis
• Alignment Length: 1171
• Identity: 324/1171 - (27%)
• Similarity: 517/1171 - (44%)
• Gaps: 298/1171 - (25%)

  Fly    10 RGRRQGR------KKAQP---MPEQAVVLVVNGRVTGGPKGTGKQKTRPGKNAKADAGDKLKSED 65
            |.|::.|      |.::|   .|...||...:....|..||.        |:.:.|       |:
 Frog    25 RSRKEARETGPHEKMSRPNSTSPRPNVVKKPSPANPGRSKGL--------KDIRID-------EE 74

  Fly    66 EKMLRQL-VDDFLQSCEPEKQLP-GLTKAQRSHVHRLAQHRGLKTVSKGPEENRVLFISRPQ-SD 127
            .|:...: ::.|..|.:.|.:.| .||..:|:.:|||||..||.:.|||...||.|.:.:.. |:
 Frog    75 VKIAVNIALEKFRYSDQKEMEFPSSLTSTERAFIHRLAQSLGLVSKSKGKGPNRCLTLKKKNGSE 139

  Fly   128 GQQQYILC----NTKLDICP-----PLLDVLGQMAGNVERRLM---NSVGDLKCNKQQYKDIRLP 180
            .....:.|    |||..:|.     ||.        |.||..:   ...|::...:.:.::|...
 Frog   140 ASSSLMSCTLTQNTKKAVCNLIQRFPLT--------NKERTELLPKTERGNVYAIEAENREIGKT 196

  Fly   181 SNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQY 245
            |  |.:...:...|...........|:|||:::::|.|:.:::.::|::|.|.|||||:||:||:
 Frog   197 S--GCLNGGIPQVPDKRGESKYDFFRQSLPVFEKQEDIIRIIKNNKVVLIVGETGSGKTTQIPQF 259

  Fly   246 ILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSG 310
            ||:...::..|.||..:||||:|||||:||::.||||..|..|||.||:..:.|..|:|...|:|
 Frog   260 ILDNCQKNGLPCRIFCTQPRRLAAISVAERVAAERGEIIGQCVGYQIRLESRVSPKTLLTFCTNG 324

  Fly   311 CLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSN 375
            .|||.| |...|.....||:|:||.||||..:||||...:..:|::|.|:|:|.||.:|:.....
 Frog   325 VLLRTL-MGGDSTLSAITHIIVDEVHERDRFSDFLLTKLRDAIQEHPTLKLILSSAALDVNLFIR 388

  Fly   376 YFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKF-------------------------- 414
            ||||..|:.::||.|||....|||||..|||.:..|.|:
 Frog   389 YFGGCPVIYIQGRPFEVKEMFLEDILRSTGYRNKGMLKYNKEKQCEEKQKTTLTEWYSAKQKNMK 453

  Fly   415 --------------------------LGKPTGKE------------------------------- 422
                                      .|:.|.|:
 Frog   454 PETQRQRSVPAIKEEYDILDDGGDTAFGQMTEKDANCLEPWLIKEIDACLSDIWLYRDKDAFAQL 518

  Fly   423 --------------------TP------------------------------------------- 424
                                ||
 Frog   519 FHLISTENVSVDYRHSETSATPLMVAAGQGFLSHVEQLISMGANIQSKASNGWMALDWAKHFGQT 583

  Fly   425 --SELLAAYYGG--------NTIVHPD-----------------------IDNDLIVSLLELLLR 456
              .:||.:|...        ||:|..|                       :|.|||:.:|..:.:
 Frog   584 EVVDLLESYSASLETEDLDENTLVQSDGNDLSIEDRELLKAYHHSFDDEKVDLDLIMHVLFNICQ 648

  Fly   457 QGDAGAVIVYLPGYSDMTSLLARLESSLPR-----EQITIILLHSQVDNSEQRKVFRTYP-GVRL 515
            ..|.||::::||||.::..|..|:.....|     ::..:.:|||.:..|:|:||.:..| |:|
 Frog   649 ITDTGAILIFLPGYDEIVGLRDRILLDDKRFADNAQRYHVFMLHSNMQTSDQKKVLKLPPAGIR- 712

  Fly   516 KIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGN 580
            ||||||||.:||||:.|:::|||:|..|.|::|:..:.:.|.:.|||:|.|.||.|||||...|.
 Frog   713 KIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNNVTMLKMVWISKASAIQRKGRAGRCRPGI 777

  Fly   581 CYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAP-DKKIENFLALALDTPPKDAVMQSCSR 644
            |:||:...|...|..:..||::|..|.|:||.|||..| :..:.:||..|.:.||...|..:...
 Frog   778 CFRLFSKLRFQNMLEFQTPELLRIPLHELCLHTKLLVPINCPVADFLMKAPEPPPALIVRNAVQM 842

  Fly   645 LKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERG 709
            ||.:..:|..:::|.:||.:|:||:...:||.::.::.|:|||.::.||...:.||||||..:..
 Frog   843 LKTIDAMDNWEDLTEIGHHLADLPVEPHLGKMVLCAVILKCLDPILTIACTLAYRDPFVLPSQAS 907

  Fly   710 KKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIG---DFCERNFICRNAMEMFVSAASTL 771
            :|....:.|..|.....||.:|:::.::.:.  |.|..|   .|||:||:.:..||:.:.    |
 Frog   908 QKRAAMLCRKRFTAGTFSDHMALLRAFQAWQ--KAKSDGWERAFCEKNFLSQATMEIIIG----L 966

  Fly   772 RDTVYRIFRFSEASARLASSFNNDTN-------MIRLALTAGLYPKLAYMDRENKNQLVAEG--D 827
            |..:....|.|............|.|       :::.||.:|:||.|.::||||   :|..|  :
 Frog   967 RTQLLGQLRASGFVRARGGGDIRDVNINSENWAVVKAALLSGMYPNLIHVDREN---MVLSGVKE 1028

  Fly   828 PLVQVSRSSCLRGKKKQK------------DLASEWILFVEKTRTADQISSLEHTTLVSGLMVAL 880
            ..|:...||.|...:.:|            .|.::|:::.|.|| :.:|::::..::|:.:...|
 Frog  1029 KRVRFHPSSALSEPQYKKIPSANCQAEAVQALPTDWLVYDEMTR-SHRIANIKCCSVVTPVTAVL 1092

  Fly   881 -AGGKRFITEA-----------------HGSEM---------LLCLDSWIRLKCPAEFGLQLHKV 918
             ||..|..:.|                 ..|||         .|.||.|:..:...|....|.::
 Frog  1093 FAGPARLPSSALKEPSSFQVGDGIPNDSSDSEMEDRNTFTLATLKLDEWLHFRLDPEAAGLLFQL 1157

  Fly   919 R 919
            |
 Frog  1158 R 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_573208.1	R3H	67..123	CDD:460206	21/57 (37%)
		HrpA	208..>702	CDD:441249	207/679 (30%)
		OB_NTP_bind	799..884	CDD:400182	27/99 (27%)
ythdc2	XP_004910524.1	DEXHc_YTHDC2	223..398	CDD:350745	79/175 (45%)
		ANK repeat	535..567	CDD:293786	2/31 (6%)
		ANKYR	<539..>606	CDD:440430	6/66 (9%)
		ANK repeat	569..600	CDD:293786	3/30 (10%)
		OB_NTP_bind	1001..1096	CDD:400182	26/98 (27%)
		YTH	1317..1446	CDD:410979
		R3H_DEXH_helicase	76..134	CDD:100077	21/57 (37%)
		HrpA	222..>1040	CDD:441249	248/828 (30%)