DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx34

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001272860.1	Gene:	Dhx34 / 71723	MGIID:	1918973	Length:	1145	Species:	Mus musculus

Alignment Length:	951	Identity:	266/951 - (27%)
Similarity:	397/951 - (41%)	Gaps:	261/951 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 YKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGK 238
            |.|.:....||    ||:         .:|.||.:|||.:....||..|:..||:::.|.||.||
Mouse   142 YLDFQQKQAFG----RLV---------KLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGK 193

  Fly   239 STQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTV 303
            |||:|||:|.....|     :..:||||||.||:::|:..|.....|:.|||.||.....|:.|.
Mouse   194 STQVPQYLLAAGFSH-----VACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATK 253

  Fly   304 LMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATM 368
            ::..|.|.|||.:  .::........||:||.|||.|..||||...:..|.:.|.|:::|||||:
Mouse   254 IVFLTVGLLLRQI--QREPSLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATI 316

  Fly   369 DLEALSNYFGGGTVMDVEGRSFEVSIYH----LEDILSKTGYMHPRMEKFLGKPTGKETPSELLA 429
            ::...|:||....|:.|.||.|.:::.:    .:...||:..:.||  .||          .:|.
Mouse   317 NISLFSSYFSHAPVVQVPGRLFPITVVYQPQEADQTASKSEKLDPR--PFL----------RVLE 369

  Fly   430 AYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLL--ARLESSLPREQITII 492
            |           |||.         ....:.|.::|:|.|.:::|::|  |:..:||.:..: ::
Mouse   370 A-----------IDNK---------YPPEERGDLLVFLSGMAEITTVLDAAQAYASLTQRWV-VL 413

  Fly   493 LLHSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQL 556
            .|||.:..|:|.|||...| ||| |.||||||.:||:||..:.:|:|:|..|..:||......:|
Mouse   414 PLHSALSVSDQDKVFDVAPAGVR-KCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRL 477

  Fly   557 TLTWISQADAKQRAGRAGRVCHGNCYRLY---DNDRMARMNLYTIPEIMRRTLDEICLLTK-LAA 617
            ...|||||.|:||.|||||...|.|||||   |.|..|.   |.:|||.|..||.:.|..| ::.
Mouse   478 QEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAP---YPVPEIRRVALDALVLQMKSMSV 539

  Fly   618 PDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIY 682
            .|.:...|    ::.||..:|..:...|:..|.||..:.:||:|.::|:||:.|.|||.|:....
Mouse   540 GDPRTFPF----IEPPPPASVETAILYLQEQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSM 600

  Fly   683 LRCLDSMIIIAAYHSVR-------------------------DPFVL------------------ 704
            ....:.::.|||..||:                         |||.|
Mouse   601 FSLAEPVLTIAAALSVQSPFTRSAQSNLDCATARRPLESDQGDPFTLFNVFNAWVQVKSERSGNS 665

  Fly   705 ------------------NIER---------GKKSGQQISRVLFAGD------------------ 724
                              |:.|         |..||.|   |:..||
Mouse   666 RKWCRRRGVEEHRLYEMANLRRQFKELLEDHGLLSGAQ---VVAPGDSYSRLQQRRERRALHQLK 727

  Fly   725 -----GMSDSLAVIKLYE----------EFTNLKRKDIGDFCERNFICRNAMEMFVSAASTLRDT 774
                 |......|::|.|          |.:..:|.|..|..:..|..|:.:|...:|||:.:|.
Mouse   728 RQHEEGGGRRRKVLRLQEDGCSSDEEDREGSTSQRADSVDIQDVKFKLRHNLEQLQAAASSAQDL 792

  Fly   775 VYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMD-----RENKNQL------------ 822
            .                 .:...:::|.|..||||:||..|     |::.:|:
Mouse   793 T-----------------RDQLALLKLVLGRGLYPQLAVPDAFNSGRKDSDQIFHTQAKQGTVLH 840

  Fly   823 ---VAEGDPLV---QVSRSSCLRGKKKQKDLAS---EWILFVEKTRT-------ADQISSLEHTT 871
               |....|.|   |...:|...|.:..:|..|   :.:.||....|       ..:|.:|:...
Mouse   841 PTCVFANSPEVLHTQGQEASGQEGSQDGRDQMSCKHQLLAFVSLLETNKPYLVNCVRIPALQSLL 905

  Fly   872 LVSGLMVALAGGKRFITEAHGSEMLLCLDSWIRLK----------CPAEFGLQLHKVRMLTDREF 926
            |.|          |.| :.:|....|..|.|:.|:          ......|::|....| ||:.
Mouse   906 LFS----------RSI-DTNGDCSRLVADGWLELQLADSESAVRLLATSLRLRVHWESAL-DRQL 958

  Fly   927 AKLVATRKLSLMSDF----IGPETV----RRLLE---ADVP 956
            |:....|||....|.    :.|:.|    |.||:   |.||
Mouse   959 ARQAQRRKLEQEEDMGSPAVSPQEVAALSRELLQFMVAKVP 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	69/180 (38%)
		DEXDc	226..368	CDD:238005	57/141 (40%)
		HELICc	479..575	CDD:197757	43/96 (45%)
		HA2	648..733	CDD:214852	33/177 (19%)
		OB_NTP_bind	783..884	CDD:285018	26/133 (20%)
Dhx34	NP_001272860.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		HrpA	153..>688	CDD:224557	188/591 (32%)
		DEAH box	281..284		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..764		6/37 (16%)
		OB_NTP_bind	800..910	CDD:369483	26/119 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1091..1114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820