DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx16

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_006524936.1	Gene:	Dhx16 / 69192	MGIID:	1916442	Length:	1049	Species:	Mus musculus

Alignment Length:	1004	Identity:	255/1004 - (25%)
Similarity:	419/1004 - (41%)	Gaps:	228/1004 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EEAV---------KRGRRQG-RKKAQ--PMPEQAVVLVVNGRVTGGPKGTGKQK----------- 46
            ||||         ||.||:. |||.|  ...|:..|.....|..||.|...::|
Mouse   107 EEAVGSNGSSLQKKRKRRKHLRKKHQEDEEDEEEEVSESGKRKAGGSKSPTEEKPASEDEWERTE 171

  Fly    47 -----------------------------TRPGKNAKADAGDKLK--SEDEKML----------- 69
                                         .|..|.|..:|..:||  .||.|.:
Mouse   172 RERLQDLEERDAFAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVPELRKKSRRE 236

  Fly    70 ------RQLVDDFLQSCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGPEENRVLFISRPQSDG 128
                  |:.::|.......|:.|.|..:..|.....|...|.::.:::   |.|        :.|
Mouse   237 YLAKREREKLEDLEAELADEEVLFGDVELSRHERRELKYKRRVRDLAR---EYR--------AAG 290

  Fly   129 QQQYILCNTKLDICPPLLDVLGQMA-------------GNVERR----------LMNSVGDLKCN 170
            :|:.:....:..: |.  :..||.|             |..:||          |.....|....
Mouse   291 EQEKLEATNRYHM-PK--ETRGQPARTVDIVEEESGAPGEEQRRWEEAQLGAASLKFGARDAAAQ 352

  Fly   171 KQQYKDI------------------RLPSNFGLVGQRLIPP--PQSNRNRNIQHERRSLPIYKQR 215
            :.:|:.:                  ..||.         ||  .|:.:..:||..|||||::..|
Mouse   353 EAKYQLVLEEDETIEFVRAAQLQGDEEPSG---------PPLSAQAQQKESIQAVRRSLPVFPFR 408

  Fly   216 ESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKER 280
            |.:|..:...|||||:|.|||||:||:|||:.|.....:. ::|..:||||:||:||:.|:::|.
Mouse   409 EELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTKKG-MKIACTQPRRVAAMSVAARVAREM 472

  Fly   281 GEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAM--DKKSFFKNTTHLIIDEAHERDLDTD 343
            |...|..|||:||.....|..|||...|.|.|||....  |..|:    :.:::||||||.|.||
Mouse   473 GVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLASY----SVVMVDEAHERTLHTD 533

  Fly   344 FLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMH 408
            .|....|...:..|.|::::.|||:|....|.:|....|..:.||.|.|.|::.
Mouse   534 ILFGLIKDVARFRPELKVLVASATLDTARFSAFFDDAPVFRIPGRRFPVDIFYT----------- 587

  Fly   409 PRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDM 473
                        |...::.|.|               .:||:|::.:.| ..|.::|:|.|  .:
Mouse   588 ------------KAPEADYLEA---------------CVVSVLQIHVTQ-PPGDILVFLTG--QV 622

  Fly   474 TSLLARLESSLPR------------EQITIILLHSQVDNSEQRKVFR-TYPGVRLKIILSTNIGQ 525
            ::::..:|::...            .::.::.:::.:.:..|.::|: |.||.| |::::|||.:
Mouse   623 SAVVEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGAR-KVVVATNIAE 686

  Fly   526 TSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDN-DR 589
            ||:||..::||:|.|..|.|:|:.......||:|..|:|.|.|||||||||..|.|:|||.. ..
Mouse   687 TSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAY 751

  Fly   590 MARMNLYTIPEIMRRTLDEICLLTK-LAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDE 653
            ...:...|:|||.|.:|..:.||.| |...|....:|    ||.||.:.::.:..:|..||.|:.
Mouse   752 QHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDF----LDPPPYETLLLALEQLYALGALNH 812

  Fly   654 RDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISR 718
            ..|:|..|..:||||:...:.|.::.|....|.:.::.:||..||.:. :....:.|......:|
Mouse   813 LGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNS-IFYRPKDKVVHADNAR 876

  Fly   719 VLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSE 783
            |.|...| .|.|.::.:|.::......  ..:|..||:...:|.    .|..:|:.:..:....|
Mouse   877 VNFFLPG-GDHLVLLNVYTQWAESGYS--SQWCYENFVQFRSMR----RARDVREQLEGLLERVE 934

  Fly   784 ASARLASSFNNDTNMIRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLA 848
            ..   .:|...|...:|.|:|:|.:...|        :|...|...|:..::..:.......:..
Mouse   935 VG---LTSCQGDYVRVRKAITSGYFYHTA--------RLTRSGYRTVKQQQTVFIHPNSSLFEQQ 988

  Fly   849 SEWILFVEKTRTAD----QISSLEHTTLV 873
            ..|:|:.|...|..    |:..:|.:.|:
Mouse   989 PRWLLYHELVLTTKEFMRQVLEIESSWLL 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	13/75 (17%)
		DEXDc	214..395	CDD:214692	73/182 (40%)
		DEXDc	226..368	CDD:238005	61/143 (43%)
		HELICc	479..575	CDD:197757	34/108 (31%)
		HA2	648..733	CDD:214852	24/84 (29%)
		OB_NTP_bind	783..884	CDD:285018	18/95 (19%)
Dhx16	XP_006524936.1	PTZ00121	<147..>410	CDD:173412	49/285 (17%)
Dhx16	XP_006524936.1	HrpA	377..1036	CDD:224557	205/720 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810