Protein Alignment CG8915 and YTHDC2

DIOPT Version :10

• Sequence 1: NP_573208.1
• Gene: CG8915 / 32715
• FlyBaseID: FBgn0030833
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_011541883.1
• Gene: YTHDC2 / 64848
• HGNCID: 24721
• Length: 1439
• Species: Homo sapiens
• Alignment Length: 1147
• Identity: 316/1147 - (27%)
• Similarity: 506/1147 - (44%)
• Gaps: 277/1147 - (24%)

  Fly    20 QPMPEQAVVLVVNGRVTGGPKGTGKQKTRPGKNAKADAGDKLKSEDEKML--RQLVDDFLQSCEP 82
            ||.|             ||..|.|.....||...:|.....::.::|..:  ...::.|....:.
Human    11 QPAP-------------GGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQR 62

  Fly    83 EKQLP-GLTKAQRSHVHRLAQHRGLKTVSKGPEENRVLFISRPQSDGQQ---QYILCNTKLDICP 143
            |.:.| .||..:|:.:|||:|..||.:.|||...||.|.:.:  .||.:   ..:.||...:...
Human    63 EMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKK--KDGSETAHAMMTCNLTHNTKH 125

  Fly   144 PLLDVLGQM-AGNVERRLM---NSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQH 204
            .:..::.:. ..|.||..:   ...|::...:.:.:::...|  |.:...:...|..........
Human   126 AVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTS--GRLNNGIPQIPVKRGESEFDS 188

  Fly   205 ERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAA 269
            .|:|||:::::|.|:.:::.::|::|.|.|||||:||:||::|:...::..|.||..:||||:||
Human   189 FRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAA 253

  Fly   270 ISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDE 334
            |:|:||::.||.|..|.|:||.||:..:.|..|:|...|:|.|||.| |...|.....||:|:||
Human   254 IAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTL-MAGDSTLSTVTHVIVDE 317

  Fly   335 AHERDLDTDFLLLATKLE--LQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHL 397
            .||||..:||||  |||.  |||:|.|:|:|.||.:|:.....|||...|:.::||.|||....|
Human   318 VHERDRFSDFLL--TKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFL 380

  Fly   398 EDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYY-----------------------------G 433
            ||||..|||.:..|.|:..:...:|.....|..:|                             |
Human   381 EDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDG 445

  Fly   434 GNTI----------------------------VHPDIDN-------------------------- 444
            |:.:                            :|.|||.
Human   446 GDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSATA 510

  Fly   445 ----------------------------------------------------------------- 444
                                                                             
Human   511 LMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSATLEFGNLDESS 575

  Fly   445 -------------------------------DLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLA 478
                                           |||:.||..:....|||||:::||||.::..|..
Human   576 LVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRD 640

  Fly   479 RL-------ESSLPREQITIILLHSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLY 535
            |:       ..|..|.|  :.:|||.:..|:|:||.:..| ||| ||||||||.:||||:.|:::
Human   641 RILFDDKRFADSTHRYQ--VFMLHSNMQTSDQKKVLKNPPAGVR-KIILSTNIAETSITVNDVVF 702

  Fly   536 VIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPE 600
            |||:|..|.|::|:....:.|.:.|||:|.|.||.|||||...|.|:||:...|...|..:..||
Human   703 VIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPE 767

  Fly   601 IMRRTLDEICLLTKLAAP-DKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIV 664
            ::|..|.|:||.|||.|| :..|.:||..|.:.||...|..:...||.:..:|..:::|.||:.:
Human   768 LLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHL 832

  Fly   665 AELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDS 729
            |:||:...:||.::.::.|:|||.::.||...:.||||||..:..:|....:.|..|.....||.
Human   833 ADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDH 897

  Fly   730 LAVIKLYEEFTNLKRKDIG---DFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEA----SAR 787
            :|:::.::.:.  |.:..|   .|||:||:.:..||:.:...:.|...: |...|..|    ..|
Human   898 MALLRAFQAWQ--KARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQL-RASGFVRARGGGDIR 959

  Fly   788 LASSFNNDTNMIRLALTAGLYPKLAYMDRENKNQLVAEG--DPLVQVSRSSCLRGKKKQ------ 844
            ..::.:.:..:::.||.||:||.|.::||||   ||..|  :..|:...:|.|...:.:
Human   960 DVNTNSENWAVVKAALVAGMYPNLVHVDREN---LVLTGPKEKKVRFHPASVLSQPQYKKIPPAN 1021

  Fly   845 ------KDLASEWILFVEKTRTADQISSLEHTTLVSGL-MVALAGGKRFITEA------------ 890
                  |.|.::|:::.|.|| |.:|:::...:.|:.: ::...|..|..:.|
Human  1022 GQAAAIKALPTDWLIYDEMTR-AHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSFRVDGI 1085

  Fly   891 ----HGSEM---------LLCLDSWIRLKCPAEFGLQLHKVR 919
                ..|||         .|.||.|:......|....|.::|
Human  1086 PNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLR 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_573208.1	R3H	67..123	CDD:460206	18/58 (31%)
		HrpA	208..>702	CDD:441249	212/683 (31%)
		OB_NTP_bind	799..884	CDD:400182	27/99 (27%)
YTHDC2	XP_011541883.1	R3H_DEXH_helicase	46..104	CDD:100077	18/57 (32%)
		HrpA	188..>948	CDD:441249	234/768 (30%)
		DEXHc_YTHDC2	193..368	CDD:350745	80/177 (45%)
		ANK repeat	505..537	CDD:293786	0/31 (0%)
		ANK repeat	539..564	CDD:293786	0/24 (0%)
		OB_NTP_bind	971..1066	CDD:400182	26/98 (27%)
		YTH	1289..1404	CDD:410979