DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx38

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_848467.1	Gene:	Dhx38 / 64340	MGIID:	1927617	Length:	1228	Species:	Mus musculus

Alignment Length:	904	Identity:	248/904 - (27%)
Similarity:	412/904 - (45%)	Gaps:	127/904 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEEAVKRGRRQGRKKAQPMPEQAVVLVVNGRVTGGPKGTGKQKTRPGKNAKADAG-------DKL 61
            ||:.|:|..:...|:.|.            |::...:...:...|...|....:|       |:.
Mouse   345 SEDYVRRREQHLHKQKQK------------RISAQRRQINEDNERWETNRMLTSGVVHRLEVDED 397

  Fly    62 KSEDEK-----MLRQLVDDFLQ-----SCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGPEEN 116
            ..||..     |:..||..||.     :.:||..:|  .|...|.:..:|: :|.:||.|..|:.
Mouse   398 FEEDNAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIP--VKDATSDLAIIAR-KGSQTVRKHREQK 459

  Fly   117 RVLFISRPQSDGQQQYILCNTKLDICPPLLDVLGQMAGNVERRLMNSVGDLKCNKQQYKDIRLPS 181
                 .|.::. .:.:.|..|||.      |::|........:.|...|.:        |.|...
Mouse   460 -----ERRKAQ-HKHWELAGTKLG------DIMGVKKEEEPDKAMTEDGKV--------DYRTEQ 504

  Fly   182 NFG-LVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQY 245
            .|. .:.::.....:..:.::|..:|:.|||:..::.:|.:::.:.::|:.|.|||||:|||.||
Mouse   505 KFADHMKEKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQY 569

  Fly   246 ILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSG 310
            :.|.......  .|..:||||:||:||::|:|:|.|...|..|||.||.....|.||::...|.|
Mouse   570 LHEDGYTDYG--MIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENTLIKYMTDG 632

  Fly   311 CLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSN 375
            .|||...  :::...:.:.:|:||||||.|:||.|....:..:.:...|:|::.|||||.|..:.
Mouse   633 ILLRESL--READLDHYSAVIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAA 695

  Fly   376 YFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHP 440
            :||...:..:.||:|.|.|     :.||                   ||.|         ..|..
Mouse   696 FFGNVPIFHIPGRTFPVDI-----LFSK-------------------TPQE---------DYVEA 727

  Fly   441 DIDNDLIVSLLELLLRQGDAGAVIVYLPGYSD--MTS--LLARLESSLPREQITIILLHSQVDNS 501
            .:...|.|.|      .|..|.:::::||..|  :||  ::..||.......:.::.::||:.:.
Mouse   728 AVKQSLQVHL------SGAPGDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSD 786

  Fly   502 EQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQAD 565
            .|.|:|:..| ||| |.|::|||.:||:|:..:::|||:|..|:|.::..|....|.:..||||:
Mouse   787 LQAKIFQKAPDGVR-KCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQAN 850

  Fly   566 AKQRAGRAGRVCHGNCYRLYDNDRMARMNL-YTIPEIMRRTLDEICLLTK-LAAPDKKIENFLAL 628
            |.||:|||||...|.|:|||.........| .|:|||.|..|..:.||.| |...|....:|
Mouse   851 ANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHF--- 912

  Fly   629 ALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIA 693
             :|.||:|.::.|..:|.:||.||....:|..|.::.|.||...:.|.|:.|..:.|...:::|.
Mouse   913 -MDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIV 976

  Fly   694 AYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCERNFICR 758
            :..||  |.:....:|::......|..||.. .||.|..:.:|.::.|.....|  :|..:||..
Mouse   977 SMLSV--PAIFYRPKGREEESDQIREKFAVP-ESDHLTYLNVYLQWKNNNYSTI--WCNDHFIHA 1036

  Fly   759 NAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMDRENKNQLV 823
            .||.......:.|:|.:.: .|.|.||.      ..|.:::|..:.|..:.:.|.:....:...:
Mouse  1037 KAMRKVREVRAQLKDIMVQ-QRMSLASC------GTDWDIVRKCICAAYFHQAAKLKGIGEYVNI 1094

  Fly   824 AEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALAG 882
            ..|.| ..:..:|.|.|.....|    :|::.|...|..:.  ::..|.|.|..:|..|
Mouse  1095 RTGMP-CHLHPTSSLFGMGYTPD----YIVYHELVMTTKEY--MQCVTAVDGEWLAELG 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	18/68 (26%)
		DEXDc	214..395	CDD:214692	66/180 (37%)
		DEXDc	226..368	CDD:238005	55/141 (39%)
		HELICc	479..575	CDD:197757	37/96 (39%)
		HA2	648..733	CDD:214852	24/84 (29%)
		OB_NTP_bind	783..884	CDD:285018	20/100 (20%)
Dhx38	NP_848467.1	DEXDc	527..714	CDD:214692	70/190 (37%)
		DEXDc	552..688	CDD:238005	55/139 (40%)
		HELICc	759..862	CDD:197757	39/103 (38%)
		HA2	931..1013	CDD:214852	24/84 (29%)
		OB_NTP_bind	<1064..1147	CDD:285018	18/90 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810