DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and dhx8

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_002663993.1	Gene:	dhx8 / 606595	ZFINID:	ZDB-GENE-050809-39	Length:	1210	Species:	Danio rerio

Alignment Length:	843	Identity:	236/843 - (27%)
Similarity:	389/843 - (46%)	Gaps:	123/843 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EDEKMLRQLVDDFLQSCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGPE-------------- 114
            |||.:..:||::     ||    |.|    |.|..:......:|.| |.|:
Zfish   423 EDEDLEIELVEE-----EP----PFL----RGHTKQSMDMSPVKIV-KNPDGSLSQAAMMQSALA 473

  Fly   115 -ENRVLFISRPQSDGQQQYILCNTKLDICPPLLDVLG-QMAGNVERRLMNSVGDLKCNKQQYKDI 177
             |.|.  :.:.|.:.:...|..........||.||.| |:|.|     |..:|.:..:..::|..
Zfish   474 KERRE--VKQAQREAEMDSIPMGLNKHWVDPLPDVDGRQIAAN-----MRGIGMMPNDIPEWKKH 531

  Fly   178 RLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQL 242
            ....|....|::        ...:|..:|.||||||.:|.::..:..:|:||:.|.|||||:||:
Zfish   532 AFGGNKASYGKK--------TQLSILEQRESLPIYKLKEQLIQAVHDNQILIVIGETGSGKTTQI 588

  Fly   243 PQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLT 307
            .||:.|  |.:....:|..:||||:||:||::|:|:|.|...|..|||.||.....|..||:...
Zfish   589 TQYLAE--AGYTTRGKIGCTQPRRVAAMSVAKRVSEEYGCCLGQEVGYTIRFEDCTSPETVIKYM 651

  Fly   308 TSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEA 372
            |.|.|||...:|..  ......:::||||||.:.||.|....|..:||...::|::.|||:|...
Zfish   652 TDGMLLRECLIDPD--LGQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRTDMKLIVTSATLDAVK 714

  Fly   373 LSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTI 437
            .|.||....:..:.||::.|.:.:.                       ||..::.|.|
Zfish   715 FSQYFYEAPIFTIPGRTYPVEVLYT-----------------------KEPETDYLDA------- 749

  Fly   438 VHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTS----LLARLESSLPR-EQITIILLHSQ 497
                    .:::::::.|.: ..|.::|:|.|..::.:    |..|::|..|. .::.|:.::|.
Zfish   750 --------SLITVMQIHLTE-PPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSA 805

  Fly   498 VDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWIS 562
            :.:..|.::|...|....|::::|||.:||:||..:.||:|.|..|.|.|:|.....||.:|.||
Zfish   806 LPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPIS 870

  Fly   563 QADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYT--IPEIMRRTLDEICLLTKLAAPDKKIENF 625
            ||.||||||||||...|.||||| .:|..|..:.|  :|||.|..|....|..|...    |.:.
Zfish   871 QAQAKQRAGRAGRTGPGKCYRLY-TERAYRDEMLTTNVPEIQRTNLASTVLSLKAMG----INDL 930

  Fly   626 LAL-ALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSM 689
            |:. .:|.||.:.::.:..:|..||.||:...:|.||..:||.||...:.|.|:.|::|.|.:.|
Zfish   931 LSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEM 995

  Fly   690 IIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCERN 754
            :.|.:..||::.|....::...:.|:.:: ....:|  |.|.::.:|..:.|  .|....:|..|
Zfish   996 LTIVSMLSVQNVFYRPKDKQALADQKKAK-FHQPEG--DHLTLLAVYNSWKN--NKFSNPWCYEN 1055

  Fly   755 FICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMD-REN 818
            ||...::.    .|..:|..:..|....:..   ..|....|..::.|:.:|.:...|..| :|.
Zfish  1056 FIQARSLR----RAQDIRKQMLGIMDRHKLD---VVSCGKATVRVQKAICSGFFRNAAKKDPQEG 1113

  Fly   819 KNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALA 881
            ...|:.:  .:|.:..||.|..::      .||:::.|...|..:... |.||:....:|..|
Zfish  1114 YRTLIDQ--QVVYIHPSSALFNRQ------PEWVVYHELVLTTKEYMR-EVTTIDPRWLVEFA 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	17/73 (23%)
		DEXDc	214..395	CDD:214692	67/180 (37%)
		DEXDc	226..368	CDD:238005	58/141 (41%)
		HELICc	479..575	CDD:197757	39/96 (41%)
		HA2	648..733	CDD:214852	25/84 (30%)
		OB_NTP_bind	783..884	CDD:285018	21/100 (21%)
dhx8	XP_002663993.1	S1_DHX8_helicase	257..333	CDD:240189
dhx8	XP_002663993.1	HrpA	542..1209	CDD:224557	204/703 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810