DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and DHX35

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_068750.2	Gene:	DHX35 / 60625	HGNCID:	15861	Length:	703	Species:	Homo sapiens

Alignment Length:	704	Identity:	195/704 - (27%)
Similarity:	342/704 - (48%)	Gaps:	102/704 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 NIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILE--WAAEHRAPVRIVVSQ 263
            :|:.:|:.||::|.|..||.:::..|.::|.|.||.|||||:|||:.|  |.||.|.   :.|:|
Human    46 SIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRV---VGVTQ 107

  Fly   264 PRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSN--TVLMLTTSGCLLRALAMDKKSFFKN 326
            |||:||::|:.|:::|||...|..|||.||.: .|:..  |.:...|.|.|:|.:.:|  .....
Human   108 PRRVAAVTVAGRVAEERGAVLGHEVGYCIRFD-DCTDQLATRIKFLTDGMLVREMMVD--PLLTK 169

  Fly   327 TTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGG----------T 381
            .:.:::||||||.|.||..:...|...:|...|||::.|||:|.:...::|...          .
Human   170 YSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCV 234

  Fly   382 VMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDL 446
            ::.||||:|.|.|::|:..:                                      ||.....
Human   235 ILTVEGRTFPVDIFYLQSPV--------------------------------------PDYIKST 261

  Fly   447 IVSLLELLLRQGDAGAVIVYLPGYSD---MTSLLARLESSLPR----EQITIILLHSQVDNSEQR 504
            :.:::::...:|| |.|:.:|.|..:   :.|:|.....:|.|    ..:.::.:::.:.:.||.
Human   262 VETVVKIHQTEGD-GDVLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVLPMYAGLPSFEQM 325

  Fly   505 KVF-RTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQ 568
            ||| |....|| |:|::||:.:|||||..::||||.|..|::.|:.......|.:..:|||.|.|
Human   326 KVFERVSRSVR-KVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQ 389

  Fly   569 RAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLAL-ALDT 632
            ||||.||...|.|||||..:...::...|:||:.|..|..:.|..|...    |:|.|.. .:..
Human   390 RAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALG----IDNVLRFHFMSP 450

  Fly   633 PPKDAVMQSCSRLKLLGVLDERDEVT-PLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYH 696
            ||..:::|:...|..||.||:...:| |||..:||.||.....|.|:.|....|...::.|||..
Human   451 PPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMM 515

  Fly   697 SVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCERNFICRNAM 761
            .:::.||:...: |....::.|.....:|  |.|.::.:||.|  :|......:|:.:|:....:
Human   516 QIQNIFVVPPNQ-KSHAIRVHRKFAVEEG--DHLTMLNIYEAF--IKHNKDSKWCQEHFLNYKGL 575

  Fly   762 EMFVSAASTLRDTVYRI---FRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMDRENKNQLV 823
                ..|:|:|:.:.::   |:....|:      ..|.:::...:.:|.:...|........:.:
Human   576 ----VRAATVREQLKKLLVKFQVPRKSS------EGDPDLVLRCIVSGFFANAARFHSTGAYRTI 630

  Fly   824 AEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTAD----QISSLEHTTLV 873
            .: |..:.:..:|.|..:|..:     |:::.|..:|:.    .::::|...|:
Human   631 RD-DHELHIHPASVLYAEKPPR-----WVIYNEVIQTSKYYMRDVTAIESAWLL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	71/194 (37%)
		DEXDc	226..368	CDD:238005	59/145 (41%)
		HELICc	479..575	CDD:197757	36/100 (36%)
		HA2	648..733	CDD:214852	26/85 (31%)
		OB_NTP_bind	783..884	CDD:285018	13/95 (14%)
DHX35	NP_068750.2	DEXDc	53..224	CDD:214692	68/176 (39%)
		DEXDc	73..211	CDD:238005	58/143 (41%)
		DEAH box	176..179		2/2 (100%)
		HELICc	301..396	CDD:197757	36/95 (38%)
		HA2	465..549	CDD:214852	26/86 (30%)
		OB_NTP_bind	584..683	CDD:285018	14/107 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810