Protein Alignment CG8915 and DHX33

DIOPT Version :10

• Sequence 1: NP_573208.1
• Gene: CG8915 / 32715
• FlyBaseID: FBgn0030833
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_064547.2
• Gene: DHX33 / 56919
• HGNCID: 16718
• Length: 707
• Species: Homo sapiens
• Alignment Length: 722
• Identity: 207/722 - (28%)
• Similarity: 339/722 - (46%)
• Gaps: 111/722 - (15%)

  Fly   187 GQRLIPP---------PQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQL 242
            |:|..||         |::     ::.:||||||::.|..:|..|:.....::.|.|||||:||:
Human    48 GRRQQPPLAQPSASPYPEA-----VELQRRSLPIFQARGQLLAQLRNLDNAVLIGETGSGKTTQI 107

  Fly   243 PQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLT 307
            |||:.|.....:.  .|.|:||||:||||::.|:|.|:....|..|||.:|.:...|.:|.:...
Human   108 PQYLYEGGISRQG--IIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFDDVTSEDTRIKFL 170

  Fly   308 TSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKL------ELQKNPHLRLVLMSA 366
            |.|.|||....|  |..:..:.:|:||||||.:.||.|....|.      ||.|.| |::::|||
Human   171 TDGMLLREAISD--SLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLP-LKVIVMSA 232

  Fly   367 TMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAY 431
            |||::..|.||.|..|:.:|||...:.:::.:.  .:..|:|                    ||
Human   233 TMDVDLFSQYFNGAPVLYLEGRQHPIQVFYTKQ--PQNDYLH--------------------AA- 274

  Fly   432 YGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSD---MTSLLARLESSLPR--EQITI 491
                           :||:.::......:..::|:|.|..:   |:.....:...||.  ..:.:
Human   275 ---------------LVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPAMLV 324

  Fly   492 ILLHSQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQL 556
            :.|::.:..::|.:||:..|....|:|:||||.:|||||..:.||:|||:.|.|.|:.......|
Human   325 LPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVL 389

  Fly   557 TLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKK 621
            .:..:|:..|.||.|||||...|.|||||..|...:.:..|:|||.|..|..:.|  :|.|  .|
Human   390 AVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLASVML--QLLA--MK 450

  Fly   622 IENFLAL-ALDTPPKDAVMQSCSRLKLLGVLDERDE---VTPLGHIVAELPLGVQIGKCLVYSIY 682
            :.|.|.. .:..|..|.:..:.::|.|||.|:.:|:   :||:|..:|..||..:..|.::.|..
Human   451 VPNVLTFDFMSKPSPDHIQAAIAQLDLLGALEHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPK 515

  Fly   683 LRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDI 747
            ..|.:.::.|.:..|| |..:.|....::..|.:.:...:.:|  |.:.::.:|..|.||....
Human   516 FHCTEEILTIVSLLSV-DSVLHNPPSRREEVQGVRKKFISSEG--DHMTLLNIYRTFKNLGGNK- 576

  Fly   748 GDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLAL-------TA 805
             |:|:.||:....|.:.....:.|||...::      |..:||| ..|...:|..|       ||
Human   577 -DWCKENFVNSKNMTLVAEVRAQLRDICLKM------SMPIASS-RGDVESVRRCLAHSLFMSTA 633

  Fly   806 GLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCL-------RGKKKQKDLA---SEWI------LF 854
            .|.|...|...:....:......::...:.:|:       ..|...:||.   ::|:      .|
Human   634 ELQPDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTELLYTNKCYMRDLCVIDAQWLYEAAPEYF 698

  Fly   855 VEKTRTA 861
            ..|.|||
Human   699 RRKLRTA 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_573208.1	R3H	67..123	CDD:460206
		HrpA	208..>702	CDD:441249	162/508 (32%)
		OB_NTP_bind	799..884	CDD:400182	17/86 (20%)
DHX33	NP_064547.2	Required for nucleolar location. /evidence=ECO:0000269|PubMed:26100019	1..80		11/36 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64		4/15 (27%)
		HrpA	73..>700	CDD:441249	196/685 (29%)
		DEAH box	194..197		2/2 (100%)
		HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000269|PubMed:26100019	471..562		23/93 (25%)
		Critical for rDNA-binding. /evidence=ECO:0000250	547..558		1/12 (8%)