DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8915 and dhx36

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001122016.2	Gene:	dhx36 / 569072	ZFINID:	ZDB-GENE-050419-20	Length:	1037	Species:	Danio rerio

Alignment Length:	774	Identity:	236/774 - (30%)
Similarity:	391/774 - (50%)	Gaps:	75/774 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 RRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAE--HRAPVRIVVSQPRRIA 268
            |:.||.|..||.::.::..::||:|.|.||.||:||:.|:||:...:  ..:..|:|.:|||||:
Zfish   217 RKKLPSYGMREELVRLISANRVLVISGETGCGKTTQVTQFILDDFIQRGQGSLCRVVCTQPRRIS 281

  Fly   269 AISVSERISKERGE--APGTTVGYNIRM-NRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHL 330
            ||||:||::.||.|  ..|.:.||.||: :|.......|:..|:|.:|:.|..|  .:..:.|||
Zfish   282 AISVAERVAVERAEPVGEGKSCGYQIRLQSRLPRKQGSLLYCTTGVILQWLHSD--PYLSSITHL 344

  Fly   331 IIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIY 395
            ::||.|||.:.:|.|:...|..|.....|::||||||::.|..|.||....::.:.|.:|.|:.|
Zfish   345 VLDEIHERSVQSDILITIVKDLLTARDDLKVVLMSATLNAEKFSKYFNNCPMIHIPGYTFPVTEY 409

  Fly   396 HLEDILSKTGYMHPRMEKFLGKP----------TGKETPSELLAAY--------------YGGNT 436
            .|||::...|: .||.::  .||          :.:....::.|.|              :...|
Zfish   410 LLEDVVELLGF-QPRYKQ--RKPHYRKRNNHGSSARPEKGKIEAKYHESWPCYARTLRDRFSDTT 471

  Fly   437 IV-------HPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLES----SLPREQIT 490
            |.       ..:||.:|..:|:..:....:.||::|:|||:.::::|...|.|    ...|.:..
Zfish   472 IEVLGMMDDDDNIDLELTAALIRHIAVNENEGAILVFLPGWDNISTLNDLLMSDQMFKSGRYRFI 536

  Fly   491 IILLHSQVDNSEQRKVFRTY--------PGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTY 547
            ||.|||.:....|.:|...:        |||| ||:::|||.:|||||.|::||||.|..|...:
Zfish   537 IIPLHSLMPTVSQTQVISLFPQVFKKPPPGVR-KIVIATNIAETSITIDDVVYVIDGGKIKETHF 600

  Fly   548 DSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLL 612
            |:..:...:|..|:|.|:||||.||||||..|.||.||:..|.:.::.|.:|||.|..|:|:||.
Zfish   601 DTQNNIRTMTAEWVSIANAKQRKGRAGRVSPGKCYHLYNGLRASLLDNYQLPEIQRTPLEELCLQ 665

  Fly   613 TKL--AAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGK 675
            .|:  ..|   |..||...:|.|...|:..:.:.|..|..||..:::||||..:|.:|:...|||
Zfish   666 IKVLKLGP---IATFLQKTMDPPSDRAIELAITHLVDLNALDRDEKLTPLGFHLARMPVEPHIGK 727

  Fly   676 CLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFT 740
            .:::...|.|||.::.|||..|.:|||.:.:.:.|.:.|:  |.:|:.:..||.|:::..:..:.
Zfish   728 MILFGALLGCLDPVLTIAASLSFKDPFFIPLGKEKIADQR--RKMFSQNSRSDHLSIVNAFLGWE 790

  Fly   741 NLKRKDI---GDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTN--MIR 800
            :.||:..   .::|..||:..|.::|..:......:.:.|....:....:..||..|..|  :::
Zfish   791 DAKRRGSRFEREYCWDNFLSANTLQMLQNMKGQFAEHLLRAGFVNSKDPKDPSSNINSENKKLVK 855

  Fly   801 LALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKK---KQKDLASEWILFVEKTRTAD 862
            ..:.||||||:|.:...:..:.........:.....|:..|.   ::.....:|:::..|.:|..
Zfish   856 AVIVAGLYPKVAKISPSHNKKRPMPVKVYTKADGKVCIHPKSVNAEETQFQYKWLVYHLKMKTTS 920

  Fly   863 QISSLEHTTLVSGLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAEFGLQLHKVRML 921
            ..  |...|.||...:...||...|......: .:.:|.||..:.|   |...|.|:.|
Zfish   921 IF--LYDCTEVSPFSLLFFGGNISIQRDQDQD-TIAVDEWIVFQSP---GRIAHLVKDL 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	69/185 (37%)
		DEXDc	226..368	CDD:238005	59/146 (40%)
		HELICc	479..575	CDD:197757	43/107 (40%)
		HA2	648..733	CDD:214852	30/84 (36%)
		OB_NTP_bind	783..884	CDD:285018	21/105 (20%)
dhx36	NP_001122016.2	HrpA	193..992	CDD:224557	236/774 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920