Protein Alignment CG8915 and ythdc2

DIOPT Version :9

• Sequence 1: NP_001285369.1
• Gene: CG8915 / 32715
• FlyBaseID: FBgn0030833
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_021332046.1
• Gene: ythdc2 / 567114
• -ID: -
• Length: 1381
• Species: Danio rerio
• Alignment Length: 1147
• Identity: 319/1147 - (27%)
• Similarity: 502/1147 - (43%)
• Gaps: 293/1147 - (25%)

  Fly    37 GGPK---GTGKQKTRPGKNAKADAGDKLKSEDEKMLRQLVDDFLQSCEPEKQLP-GLTKAQRSHV 97
            ||.|   .:.||.......||.....::..|.:..:...::.|..|.|.|...| .||.::|:.:
Zfish     4 GGQKSNMSSSKQHQASSLKAKGFRDIRIDEEVKIAVNIALERFQYSDEKELDFPSSLTNSERAFI 68

  Fly    98 HRLAQHRGLKTVSKGPEENRVLFISRPQS-DGQQQYILCNTKLDICPPLLDVL-----------G 150
            |||||..|..:.|:|...:|.|.:.:... :.|:..:.|:.. ..|..|:..|           .
Zfish    69 HRLAQSLGYISKSRGKGCSRFLTVRKKDGMEAQRSSMSCSLS-PSCRALVQSLMQRFPISSRERS 132

  Fly   151 QMAGNVERRLMNSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQR 215
            |:..:.||.| .|..|...:|.:... ||......|      ||:.:....:...|::||:|:.:
Zfish   133 QLQPHAERGL-QSPPDTTDSKSRTSG-RLSHGIPQV------PPRRSSAPELDAFRKALPVYELQ 189

  Fly   216 ESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKER 280
            |.|:..::..||:::.|.|||||:||:||::|:..:...:|.||..:||||:|.|:|:||::.||
Zfish   190 EQIIQSIRDHQVVLVLGETGSGKTTQIPQFLLDDCSATASPCRIFCTQPRRLATIAVAERVAAER 254

  Fly   281 GEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFL 345
            ||..|.||||.||:..:.|..|:|...|||.|||.| |.........||:|:||.||||..||||
Zfish   255 GENIGQTVGYQIRLESRVSPKTLLTFCTSGVLLRTL-MAGDEALSTVTHVIVDEVHERDGLTDFL 318

  Fly   346 LLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPR 410
            |...|..|||.|:|||||.||.:|:.....|||...|:.::|..:||....|||||..|.|.:..
Zfish   319 LTKMKEVLQKMPNLRLVLSSAALDVSLFMRYFGSCPVIHIKGCPYEVKQLFLEDILRSTAYTNKD 383

  Fly   411 MEKFL---------------------------GKPT----------------------------- 419
            |.|:.                           .:||
Zfish   384 MIKYKKEAQKEESQQCSLSEWCERDVPQADPPERPTVCVLQDNQLLDDGGDSVFSQMSEKDVSSL 448

  Fly   420 ----------------------------------------------------------------- 419
                                                                             
Zfish   449 EPWLLREMDSCISSIFLNQDADAFTQLFNLILNENISVDYRHSETSATALMVSAGRGFVSHTEQL 513

  Fly   420 -----------------------GKETPS----------------------------------EL 427
                                   .|:|.:                                  ||
Zfish   514 LNMGANINIKASNGWTALDWAKHFKQTEAVDLLESHIWCAEASPQDEASLLQNSSCELSCEDQEL 578

  Fly   428 LAAYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPREQI--- 489
            |.||:  ::.....:|..||:.||..:.:..|.|||:::||||.::.||         |:||
Zfish   579 LKAYH--HSFDDEKVDLQLILHLLHSICQSSDQGAVLIFLPGYDEIVSL---------RDQILFD 632

  Fly   490 -----------TIILLHSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLA 542
                       .:.:|||.:..|:|:||.::.| ||| ||||||||.:||||:.|:::|||:|..
Zfish   633 DKRFTEHQQRFQVFVLHSSMQTSDQKKVLKSTPKGVR-KIILSTNIAETSITVSDVVFVIDSGKV 696

  Fly   543 KMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLD 607
            |.|.||:..:.:.|.:.|||:|.|.||.|||||...|.|:.|:...|.:.|..:.||:::|..|.
Zfish   697 KEKAYDALNNVTMLKMVWISKASALQRKGRAGRCRPGVCFHLFSRLRFSNMLEHQIPQLLRMPLQ 761

  Fly   608 EICLLTKLAAP-DKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGV 671
            |:||.|||.|| :..:..||:.|.:.|..:.|..:...||.:..:|..:.:|.||..:|:||:..
Zfish   762 ELCLHTKLLAPINCPVAEFLSRAPEPPHINTVKHAVQMLKTIDAMDPWENLTELGLHLADLPVEP 826

  Fly   672 QIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLY 736
            .:||.::.::.|:|||.::.||...:.|:||||..:..::....:.|..|..:..||.:|:::.:
Zfish   827 HLGKMVLCAVVLKCLDPVLTIACTLAHREPFVLPAQAAQRRVAMLCRRRFTANTFSDHMALLRAF 891

  Fly   737 EEFTNLKRKDIG---DFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEA----SARLASSFNN 794
            :.:.  |.:..|   .|||:||:.:..||:.||..:.|...: |...|..|    ..|..:..:.
Zfish   892 QAWQ--KARSDGWERAFCEKNFLSQATMEIIVSMRTQLLGQL-RATGFVRARGGGDIRDVNQNSE 953

  Fly   795 DTNMIRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQK------------DL 847
            :..:::.||.||:||.|.:.|..:   |..|.:..|::..:|.|...:.:|            .|
Zfish   954 NWAVVKAALVAGMYPNLIHRDGLS---LSGEKEKKVRLHPTSVLSQPQYKKIPPANGQAAAVDSL 1015

  Fly   848 ASEWILFVEKTRTADQISSLEHTTLVSGLMVALAGG--------------KRFITEAHGSEM--- 895
            .::|:::.|.|| |.:|:|:...|.|:.|.:||.||              :|...::..||:
Zfish  1016 PTDWLIYDEMTR-AHRIASVRCCTAVTPLTIALFGGGAKLPSSALQEAVLQRGSADSSDSEVEDQ 1079

  Fly   896 ------LLCLDSWIRLKCPAE-----FGLQ-------LHKVR 919
                  .|.||.||..:...|     |||:       |.::|
Zfish  1080 CSARQAHLTLDHWINFRLDPETAELVFGLRQRWQSVFLRRIR 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	19/59 (32%)
		DEXDc	214..395	CDD:214692	83/180 (46%)
		DEXDc	226..368	CDD:238005	73/141 (52%)
		HELICc	479..575	CDD:197757	46/110 (42%)
		HA2	648..733	CDD:214852	25/84 (30%)
		OB_NTP_bind	783..884	CDD:285018	31/130 (24%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077	18/57 (32%)
		HrpA	169..>1001	CDD:224557	246/850 (29%)
		ANK repeat	496..524	CDD:293786	0/27 (0%)
		YTH	1248..1379	CDD:309322

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48010
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106429
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3857
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.830