DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8915 and dhx32b

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_687318.4	Gene:	dhx32b / 558937	ZFINID:	ZDB-GENE-130613-5	Length:	729	Species:	Danio rerio

Alignment Length:	727	Identity:	176/727 - (24%)
Similarity:	306/727 - (42%)	Gaps:	144/727 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 PQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEW--AAEHRAP 256
            |.|:|...:..||:.||:::.:...::.|...|::|:.|...:|:|||:||:..|:  :|:::..
Zfish    36 PFSSRYYKLLRERKCLPVWEAKCEFMDSLINSQIVIVTGTAKTGQSTQIPQWCAEFCLSAQYQNG 100

  Fly   257 VRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKK 321
            : :|.:|......:.::.|::.|.....|..|||:|.:...||.:|||...|...|||.:..|
Zfish   101 M-VVCTQIHHQTTVELALRVADEMDVNIGNEVGYSIPLQACCSQDTVLRYCTDDVLLREMMSD-- 162

  Fly   322 SFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVE 386
            ...:....:::|:|.||.:.||.||...|..|...|.||||::||....|.|..::|....:.:|
Zfish   163 PLLEQCGVVVLDQAQERTVSTDLLLGLLKDVLLTRPELRLVILSAPHSSEKLLRHYGSVPQIKLE 227

  Fly   387 GRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLL 451
            |                     |:             |.|:|.....|..       .|.:.|.|
Zfish   228 G---------------------PQ-------------PCEVLFGSGRGGV-------KDYLCSAL 251

  Fly   452 ELLL---RQGDAGAVIVYLPGYSDMTSLLARLESSLPREQITIILLHSQV--------------- 498
            .|.|   :..:.|.::.:|....::....|.|.    ||...:.|.|.::
Zfish   252 RLALEIHQNENHGDIVAFLATEQEIECAHAILR----REGANLALSHGELVPVSLCPRQGDSLSL 312

  Fly   499 -DNSEQRKVFRT-YPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWI 561
             :.|:.|:||.| .|...|...|.|           :.:|||.|:.|...|:..|.|:.:.:..|
Zfish   313 TEESKSRRVFLTCSPSEDLFWALHT-----------IRFVIDAGVQKRYVYNPRIRANSIVIRPI 366

  Fly   562 SQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTK------LAAPDK 620
            |::.|:.|...||..  |.|:.||..|  ..:...::|.::...:....|..|      |:..|
Zfish   367 SKSQAESRKQLAGPT--GKCFCLYQED--TSLPAESVPHLLESDITSTVLFLKRMEIAGLSHCD- 426

  Fly   621 KIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRC 685
                    .:|.|..:.:||:...|..|..||:...::.:|.|::|.||..|:.|.|:.|....|
Zfish   427 --------LIDRPDPEGLMQALEELDYLAALDDDGNLSEIGIIMSEFPLEPQMAKTLLASCEFDC 483

  Fly   686 LDSMIIIAAYHSVRDPFVL-NIERGKKS---GQQISRVLFAGDGMSDSLAVIKLYEEFTNLK--- 743
            :..::.|||..:....|:: .:|..:|:   .|:...    .:|  |...:|.::..:...|
Zfish   484 VCEVLTIAAMLTAPSCFIIPPVEMRQKALLCHQKFQH----AEG--DHFTLINIFNAYRYAKDGS 542

  Fly   744 RKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLAS--SFNNDTNMIRLALTAG 806
            ...:..:|:.:|:...|::    .|..:|..:..|.:..|....|.:  |.:|..| :|.||.||
Zfish   543 YSKVEQWCDEHFLSLAALQ----TADAIRSELTEILKRLELPVSLPAFGSRSNSLN-VRRALLAG 602

  Fly   807 LYPKLA--------YMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKT----- 858
            .:.::|        |....:|:  ||:..||...       |.:..|....||:|:.|.|
Zfish   603 FFMQVARDIDGSGNYFMLTHKH--VAQIHPLSGY-------GLEVNKKNLPEWVLYHEHTLSENN 658

  Fly   859 --RTADQISSLE 868
              ||..|||::|
Zfish   659 CIRTVSQISAIE 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	53/182 (29%)
		DEXDc	226..368	CDD:238005	47/143 (33%)
		HELICc	479..575	CDD:197757	27/112 (24%)
		HA2	648..733	CDD:214852	22/88 (25%)
		OB_NTP_bind	783..884	CDD:285018	30/103 (29%)
dhx32b	XP_687318.4	HrpA	30..661	CDD:224557	170/716 (24%)
		DEXDc	68..207	CDD:238005	45/141 (32%)
		HA2	445..529	CDD:214852	22/89 (25%)
		OB_NTP_bind	568..678	CDD:285018	31/113 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000