DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and dhx34

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_017207416.1	Gene:	dhx34 / 555838	ZFINID:	ZDB-GENE-061207-30	Length:	1154	Species:	Danio rerio

Alignment Length:	1066	Identity:	269/1066 - (25%)
Similarity:	443/1066 - (41%)	Gaps:	282/1066 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DEKMLRQLVDDFL-----------------QSCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKG 112
            ||...||  .|::                 ||.:.:|::.. :|:.|...| :|...|     |.
Zfish    23 DEVFFRQ--HDYIQAGSAEHKEFWSFFERFQSFKAKKEMTA-SKSSRQEKH-VALREG-----KA 78

  Fly   113 PEENRVLFISRPQSDGQQQYILCNTKLDICPPLLDVLGQMAGNVERRLMNS------VGDLKCNK 171
            .::...:.:..|: |...:|   ...:.:|.  .|:..::||:..||..:|      :.|.:...
Zfish    79 KKKTGCVDLGLPK-DYDARY---RINISVCS--RDIEERLAGSDHRRRESSGPGRQEITDGRLAL 137

  Fly   172 QQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGS 236
            ..:.|.....:|..:.:             ::.|::||||::.|:.|:.:::...|:::.|.||.
Zfish   138 LHFLDFNQKQSFSKLSK-------------LRREQKSLPIFQYRDKIVELVRTHPVVVVAGDTGC 189

  Fly   237 GKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSN 301
            |||||:|||:|.....:     |..:||||||.||:::|:|.|.....|:.|||.||.....:..
Zfish   190 GKSTQVPQYLLASGINN-----IACTQPRRIACISLAKRVSFESLNQYGSKVGYQIRFETSRTLA 249

  Fly   302 TVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSA 366
            |.|:..|.|.|||.:..|  :.......||:||.|||.|..||||...:..|...|.||||||||
Zfish   250 TKLLFLTEGLLLRQIQQD--ASLGQYQVLIVDEVHERHLHCDFLLGVLRSLLSLRPDLRLVLMSA 312

  Fly   367 TMDLEALSNYFGGGTVMDVEGRSFEVSIYHL----EDILSKTGYMHPRMEKFLGKPTGKETPSEL 427
            |::::..|:||....|:.|.||.|.:.:.:.    |:.:|::..:.||....:.:...:..|.|
Zfish   313 TINIKLFSSYFNDAPVLQVPGRLFPIQVIYQPIPPEEQVSRSEKLDPRPYLRVLQGIDQRYPQE- 376

  Fly   428 LAAYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPREQITII 492
                                           :.|.::::|.|.::::::....::.....|..|:
Zfish   377 -------------------------------ERGDLLLFLSGVAEISTIQEACQTYATHTQRWIV 410

  Fly   493 L-LHSQVDNSEQRKVFR-TYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQ 555
            | |||.:..::|.|||. ..|||| |.|:||||.:||:||..:.:|:|:|..|..::|......:
Zfish   411 LPLHSTLSLAQQDKVFDIAPPGVR-KCIISTNIAETSVTIDGVRFVVDSGKVKEMSFDPKAKMQR 474

  Fly   556 LTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTK-LAAPD 619
            |...|||:|.::||.|||||...|.|||||..........|.:|||.|..||.:.|..| :...|
Zfish   475 LQEFWISRASSEQRKGRAGRTGPGVCYRLYSESDYDAFAPYPVPEIHRVALDSLILQMKSMGLGD 539

  Fly   620 KKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLR 684
            .:...|    :|.||..::..:.:.|:..|.|||..|:|.:|.::|:||:.|.|||.||......
Zfish   540 PRTFTF----IDPPPASSIQTAVTYLREQGALDEHGELTSIGRLLAQLPVDVVIGKMLVLGSVFN 600

  Fly   685 CLDSMIIIAAYHSVRDPFV---------------LNIERG------------------KKSGQQI 716
            .::.::.:||..||:.||:               ||...|                  :.||
Zfish   601 LVEPVLTVAAALSVQSPFLRSAQHNPDCSTARQPLNSNHGDPFTLMNTFNAWVQVKADRGSG--- 662

  Fly   717 SRVLFAGDGMSDSLAVIKLYEEFTNLKRK-------------DIG-------------DFCERNF 755
            ||......|:.:.    :|| |..||:|:             |.|             .|.||..
Zfish   663 SRKWCRRRGLEEQ----RLY-EMVNLRRQFKELLRSHGLLEDDTGRATEPQDRARRRERFTERQK 722

  Fly   756 I-------------------CRNAMEMFVSAAS---------------------------TLRDT 774
            :                   ....:|...|:.|                           .||..
Zfish   723 LHQLKRDHELQENTKRKVLRLEEGLEGDASSGSDAEESSTSRKKRKDGAEQTMDIQEVKFKLRHN 787

  Fly   775 VYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMD-----RENKNQL------------ 822
            |..:...:.|||.|:|.   ...:::|.|..||||:||..|     |::.:|:
Zfish   788 VNELQESAYASAALSSL---QQALLKLLLCRGLYPQLAIPDEHNATRKDSDQVFHTRNKQGVVIH 849

  Fly   823 ---VAEGDPLV------QVSRSSCLRGKKKQKDLASEWILFVEKTR----TADQISSLEHTTLVS 874
               |...||.|      :.|.....:|:..:..|.: ::..:|..:    ...::.:|:...||:
Zfish   850 PTSVFASDPEVLHVPEHETSEFGTDKGQSNRHQLLA-FVTLLETNKPYLSNCVRVPALQALLLVA 913

  Fly   875 GLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAEFGLQLHKVRMLTDREFAKLVATRKLSLMS 939
            ..:.:.|...|           |.:|.|:.|.              |||.:.|..|.:..|||.:
Zfish   914 NSVNSNADCTR-----------LVVDGWLELS--------------LTDGDAALKVLSSALSLRA 953

  Fly   940 DFIGPETVRRLLEADV--PSTCLAEG 963
            ::      .|||:|.:  ..:|.:.|
Zfish   954 EW------ERLLQAQLRQSGSCSSAG 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	14/74 (19%)
		DEXDc	214..395	CDD:214692	72/180 (40%)
		DEXDc	226..368	CDD:238005	61/141 (43%)
		HELICc	479..575	CDD:197757	39/97 (40%)
		HA2	648..733	CDD:214852	30/117 (26%)
		OB_NTP_bind	783..884	CDD:285018	28/130 (22%)
dhx34	XP_017207416.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820