DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and dhx29

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_697933.6	Gene:	dhx29 / 553505	ZFINID:	ZDB-GENE-130530-606	Length:	1377	Species:	Danio rerio

Alignment Length:	969	Identity:	299/969 - (30%)
Similarity:	469/969 - (48%)	Gaps:	170/969 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 EPEKQLPGLTKAQRSHVHR-LAQHRGLKTVSKGPEENRVLFISRPQSDGQQQYILCNTKLDICPP 144
            |.|:.|..:.|.:...:.| |.:.:..:::...||..::|..:.|:...:.    .:|:.:..|.
Zfish   474 EEEQTLLAINKPRDQFISRLLTRLKQQQSLQSQPEPQKLLQDAEPEDSWEN----LDTQEEQEPQ 534

  Fly   145 LLDVLGQMAGNV----ERRLMNSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHE 205
            .....|..||.|    .|||:               ::|.:              |...|.:..|
Zfish   535 CGAASGGPAGLVVEEASRRLL---------------LKLQA--------------SPLARRLLDE 570

  Fly   206 RRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILE---WAAEHRAPVRIVVSQPRRI 267
            |:.||:::.||.:|..|:..:||:|.|.||||||||:||:|||   .|.:...|..:||:|||||
Zfish   571 RKQLPVFQHREQVLEALRHHRVLVIAGETGSGKSTQIPQFILEELLAAGDTAQPCSVVVTQPRRI 635

  Fly   268 AAISVSERISKERG--EAPG---TTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNT 327
            :|:|::.|:|:|.|  :.||   :..||.|||..:.|..|.|:..|:|.|||.|..|:  ...:.
Zfish   636 SAMSLACRVSQELGSEDGPGSMNSLCGYQIRMENRSSEATRLLYCTTGVLLRKLQQDR--HLNSL 698

  Fly   328 THLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEV 392
            ||:|:||.|||.:.:||||...|..:.|...|||:|||||:|.:..:|||....|:.:.||:|.|
Zfish   699 THIIVDEVHERSVQSDFLLTILKEVVHKRADLRLILMSATVDCQKFANYFNRCPVVSIPGRTFPV 763

  Fly   393 SIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVH---------------PDI 442
            .::|||||:.:|||:..:..::..|...:|....:.....||.|:.|               |::
Zfish   764 EVFHLEDIVEETGYVLEQDSEYSQKFVEEEEEVNIGITQKGGKTVQHQELIVRDSASGWDLGPEL 828

  Fly   443 DN-------------------DLIVSLLELLLR--QGDA--GAVIVYLPGYS------DMTSLLA 478
            |:                   |||:.||..|.:  |.:|  |||:|:|||.:      |:.|...
Zfish   829 DHFSSRTRHILQYMNPNKINMDLILDLLAYLDKSPQFNAVDGAVLVFLPGLAHIQQLHDLLSTDK 893

  Fly   479 RLESSLPREQITIILLHSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLA 542
            |..|   :::..::.|||.:.:.:|...|...| ||| ||:|||||.:|.:||||:::|||||..
Zfish   894 RFSS---KDRYKLVALHSSLSSQDQSSAFTVPPAGVR-KIVLSTNIAETGVTIPDVVFVIDTGRT 954

  Fly   543 KMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLD 607
            |...|..:...|.|...::|:|.|.||.||||||..|.|:|||...|......|:||||:|..|:
Zfish   955 KENRYHESSQMSSLVEMFVSKASALQRQGRAGRVREGFCFRLYPKFRFESFIDYSIPEILRVPLE 1019

  Fly   608 EICL---LTKLAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVL-DERDEVTPLGHIVAELP 668
            |:||   ..:..:|    |:||:.:||.|.:.||..:.|.|:.:|.. .:...:|||||.:|.||
Zfish  1020 ELCLHIMKCEYGSP----EDFLSRSLDAPQQQAVCNAVSLLRRIGACQQDTHTLTPLGHHLAALP 1080

  Fly   669 LGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVI 733
            :.|:|||.|::.....||:.:..|||..|.:.||...:.|.:::....|.:..|.   ||.:.:.
Zfish  1081 VNVKIGKMLIFGAIFGCLEPIATIAAAMSEKSPFATPMSRKEEANLAKSALAVAN---SDHMTIY 1142

  Fly   734 KLY----EEFTNLKRKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSF-- 792
            |.|    ...|...|.:: ::|.|:|:.|.|:       .|:.:....:.|..|.:..::|..
Zfish  1143 KAYLGWRSSRTEGTRAEM-NYCRRHFLNRTAL-------ITIEEVKQELMRMVEQAGFVSSKLGR 1199

  Fly   793 -----------------NNDTNMIRLALTAGLY---------PKLAYMDRENKNQLVAEGDPLV- 830
                             ..|..:::..||||||         |.|...:|.......|:|...|
Zfish  1200 TPRPRPSTETKAPLSISTQDVCVVKATLTAGLYDNVGRILYSPSLDVQERVVCVVETAQGKAHVH 1264

  Fly   831 --QVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGS 893
              .|:|.....|          |:||.||.:.:...  |:.|||:|.|.:.|.||.   .:....
Zfish  1265 PSSVNRFLQTHG----------WMLFQEKVKYSKVF--LKDTTLISPLSMLLFGGD---IDVQHR 1314

  Fly   894 EMLLCLDSWIRLKCPAEFGLQLHKVRMLTDREFAKLVATRKLSLMSDFIGPETVRRLLE 952
            |.|:.||.||..:.|...|:....:|.|.|....:.:|..|::|..:    :|::.::|
Zfish  1315 ERLISLDGWICFQAPVRIGVIFKHLRKLIDSLLERKLANPKMNLEDE----KTIQIIIE 1369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	9/42 (21%)
		DEXDc	214..395	CDD:214692	84/188 (45%)
		DEXDc	226..368	CDD:238005	70/149 (47%)
		HELICc	479..575	CDD:197757	40/96 (42%)
		HA2	648..733	CDD:214852	27/85 (32%)
		OB_NTP_bind	783..884	CDD:285018	31/131 (24%)
dhx29	XP_697933.6	DEXDc	568..766	CDD:214692	88/199 (44%)
		DEXDc	591..738	CDD:238005	69/148 (47%)
		HELICc	841..996	CDD:238034	62/158 (39%)
		HA2	1065..1140	CDD:214852	26/77 (34%)
		OB_NTP_bind	1181..1309	CDD:285018	33/142 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820