DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and tdrd9

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001123984.1	Gene:	tdrd9 / 553222	ZFINID:	ZDB-GENE-090313-193	Length:	1342	Species:	Danio rerio

Alignment Length:	896	Identity:	246/896 - (27%)
Similarity:	402/896 - (44%)	Gaps:	231/896 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 QQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGS 236
            |:.|..:||:     |....||..::      :|...|||.|.|:.::::::.:.|:||:|||||
Zfish    63 QRRKRAQLPT-----GPGTSPPSLAS------YEYPILPITKNRQELVSLIENNSVVIIRGATGS 116

  Fly   237 GKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSN 301
            ||:|||||:||:..||...|..:||:|||:|.|..::..:::||....|:.|||.:.:.:..:.:
Zfish   117 GKTTQLPQFILDHYAERNIPCNLVVTQPRKIGATGIARWVARERKCTLGSLVGYQVGLEKMATEH 181

  Fly   302 TVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNP-HLRLVLMS 365
            |.|:..|:|.||:.|...|.  ....:|:.|||.|||..:.|||||..:..|:.|. :::::|||
Zfish   182 TKLIYVTTGVLLQKLVSSKT--LTEYSHIFIDEVHERSEELDFLLLVVRKLLRSNSRYVKVILMS 244

  Fly   366 ATMDLEALSNYFGG--------GTVMDVEGRSFEVSIYHLEDI-------------LSKTGYM-- 407
            ||::....:.|||.        ..|.:|||..:.|..|:|:::             |.:..|:
Zfish   245 ATINCIEFAEYFGSPIRNQMNPAYVFEVEGAPYAVEEYYLDELKTMLPVGVNLDLTLPQDPYITE 309

  Fly   408 --------------------HPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLLE 452
                                |.|.|:     ||..|               ||
Zfish   310 EMYNVAVSLIQSFDEMEAKDHRRSEQ-----TGSTT---------------HP------------ 342

  Fly   453 LLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPREQITIILLHSQVDNSEQRKVFRT-YPGVRLK 516
                  :.|:|:|:|||.:::..:...| |.|.|:::.:..|||.|...||..||.. .||.| |
Zfish   343 ------ERGSVLVFLPGLAEIQYMKEAL-SKLVRKRLQVYPLHSTVTLEEQNGVFLVPVPGYR-K 399

  Fly   517 IILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNC 581
            |||||||.::|:|:||:.||||..|.:....|...:...|.:||.|:....||.||||||..|.|
Zfish   400 IILSTNIAESSVTVPDVKYVIDFCLVRQLACDKETNYRCLRITWASKTSCNQRRGRAGRVSKGFC 464

  Fly   582 YRL-----YDNDRMARMNLYTIPEIMRRTLDEICLLTKL---AAPDKKIENFLALALDTPPKDAV 638
            |||     ::|:    :..::|||::|..|....|..||   ..|    .:.|:.||..|....:
Zfish   465 YRLVTRHFWENE----IPNFSIPEMLRSPLASTLLKVKLLDMGDP----RSVLSTALTPPILGDI 521

  Fly   639 MQSCSRLKLLGVLDERD--------EVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAY 695
            .::..:||.:|.|..:.        ::|.||.::|:||:.:|:||.:|......||:..:||||.
Zfish   522 ERTVLQLKQIGALSVQSNSQRQFDGDLTFLGRVLAQLPVDLQLGKLIVLGHVFGCLEECLIIAAS 586

  Fly   696 HSVRDPFVLNIERGKKSGQQI----SRVLFAGDGMSDSLAVIKLYEE-FTNLKR------KDIGD 749
            .|::..|.:      .|.||:    |::.||.:..||.:|.:..::. :|:..:      ||..:
Zfish   587 LSLKSFFAM------PSLQQLAGYRSKLSFAQNVPSDFIAYVNAFKAWYTSRAKGELRHPKDELE 645

  Fly   750 FCERNFI----CRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTN---------MIRL 801
            :.:.|.|    .|...|:|       .|...|:.||:    ...||.:|.|:         ::::
Zfish   646 WGKENCIQIKRIREVAELF-------EDLKKRVSRFN----MHISSSSNPTDYTSLHKQRFILQV 699

  Fly   802 ALTAGLYPKL---AYMDRENKNQLVAEGDPLVQVSRSS-------CLRGKKKQKDLASEWILFVE 856
            .:...|:|..   ..:|.:..::.::..||...:...:       |      .|.|.|   ||
Zfish   700 VIAGALFPNYFSQGEIDEQLASKELSGNDPKTTILIRNLPPFAFLC------YKQLQS---LF-- 753

  Fly   857 KTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGS---------EMLLCLDSWIRLKCPAEFG 912
              |...|:.|           :|..|.:.:: |.|.|         |:||.|   :|.:......
Zfish   754 --RQCGQVKS-----------IAFDGSRAYV-EFHRSCVRESGVLHEVLLAL---LRSRHTPALH 801

  Fly   913 LQLHKVRMLTDREF-------AKLVATR-----------KLSLMSDFIGPE 945
            ||:|..   .:.||       |.|..||           .:.::|..:.||
Zfish   802 LQVHHA---DEVEFHAKGKPIAHLRYTRVNVDVQSHTVSPVGVLSSSVNPE 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	69/189 (37%)
		DEXDc	226..368	CDD:238005	59/142 (42%)
		HELICc	479..575	CDD:197757	42/96 (44%)
		HA2	648..733	CDD:214852	29/96 (30%)
		OB_NTP_bind	783..884	CDD:285018	20/119 (17%)
tdrd9	NP_001123984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..81		7/22 (32%)
		DEXDc	84..262	CDD:214692	69/179 (39%)
		DEXDc	106..247	CDD:238005	59/142 (42%)
		DEAH box. /evidence=ECO:0000250\|UniProtKB:Q14BI7	211..214		2/2 (100%)
		Helicase_C	343..459	CDD:278689	49/117 (42%)
		HA2	530..622	CDD:214852	29/97 (30%)
		TUDOR	851..972	CDD:278965
		TUDOR	905..954	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920