DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and dhx38

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_957170.1	Gene:	dhx38 / 393850	ZFINID:	ZDB-GENE-040426-1144	Length:	1258	Species:	Danio rerio

Alignment Length:	910	Identity:	246/910 - (27%)
Similarity:	418/910 - (45%)	Gaps:	133/910 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADSEEAVKRGRRQGRKKAQPMPEQAVVLVVNGRVTGGPKGTGKQKTRPGKNAKADAG-------D 59
            :.|:|.||:..:..:|:.|.            |::...:...:...|...|....:|       |
Zfish   371 SSSDEYVKKREQILQKQTQK------------RISAQKRQINEDNERWETNRMLTSGVVQRLEVD 423

  Fly    60 KLKSEDEK-----MLRQLVDDFLQ-----SCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGPE 114
            :...||..     ::..||..||.     :.:||..:|  .|...|.: .:...:|.:.|.:..|
Zfish   424 EDFEEDNAARVHLLVHNLVPPFLDGRIVFTKQPEPVIP--VKDATSDM-AIISRKGSQLVRRHRE 485

  Fly   115 ENRVLFISRPQSDGQQQYILCNTKLDICPPLLDVLGQMAGNVERRLMNSVGDLKCNKQQYK-DIR 178
            :.     .|.::. .:.:.|..|||.      |::|     ::::  ...||.|...:..| |.|
Zfish   486 QK-----ERKKAQ-HKHWELAGTKLG------DIMG-----IQKK--EDGGDSKAVGEDGKVDYR 531

  Fly   179 LPSNFG-LVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQL 242
            ....|. .:.::........:.:.:..:|:.|||:..|:.:||:::.:.::|:.|.|||||:|||
Zfish   532 AEQKFADHMKEKSEASSDFAKKKTLLEQRQYLPIFAVRQQLLNIIRDNNIVIVVGETGSGKTTQL 596

  Fly   243 PQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLT 307
            .||:.|  ..:.:...:..:||||:||:||::|:|:|.....|..|||.||.....|..|::...
Zfish   597 TQYLHE--DGYTSYGMVGCTQPRRVAAMSVAKRVSEEMNSNLGEEVGYAIRFEDCTSEKTMIKYM 659

  Fly   308 TSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEA 372
            |.|.|||...  ::|...:.:.:|:||||||.|:||.|....:..:.:...|:|::.|||||.:.
Zfish   660 TDGILLRESL--RESDLDHYSAVIMDEAHERSLNTDVLFGLLREVVSRRSDLKLIVTSATMDSDK 722

  Fly   373 LSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTI 437
            .:::||...:..:.||:|.|.|     :.||                   ||.|
Zfish   723 FASFFGNVPIFHIPGRTFPVDI-----LFSK-------------------TPQE----------- 752

  Fly   438 VHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSD-------MTSLLARLESSLPREQITIILLH 495
               |.....:...|::.| .|..|.:::::||..|       :...||.||::   ..:.::.::
Zfish   753 ---DYVEAAVKQALQIHL-SGMVGDILIFMPGQEDIEVTSDQIVERLADLENA---PALAVLPIY 810

  Fly   496 SQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLT 559
            ||:.:..|.|:|:..| ||| |.|::|||.:||:|:..:::|:|:|..|:|.::..|....|.:.
Zfish   811 SQLPSDLQAKIFQKAPDGVR-KCIVATNIAETSLTVDGIMFVVDSGYCKLKVFNPRIGMDALQVY 874

  Fly   560 WISQADAKQRAGRAGRVCHGNCYRLYDNDRMA-RMNLYTIPEIMRRTLDEICLLTK-LAAPDKKI 622
            .||||:|.||||||||...|.|||||...... .|...|||||.|..|..:.||.| |...|..:
Zfish   875 PISQANANQRAGRAGRTGPGQCYRLYTQSAFKNEMLTTTIPEIQRTNLANVVLLLKSLGVQDLLL 939

  Fly   623 ENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLD 687
            .:|    :|.||:|.::.|..:|.:||.||....:||.|.::.|.||...:.|.|:.|..:.|..
Zfish   940 FHF----MDPPPEDNMLNSMYQLWILGALDNTGALTPTGRLMVEFPLDPALSKMLIVSCDMSCSA 1000

  Fly   688 SMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCE 752
            .::||.:..||  |.:....:|::......|..|:.. .||.|..:.:|.::.|.....|  :|.
Zfish  1001 DILIIVSMLSV--PSIFYRPKGREEESDQVREKFSVP-ESDHLTYLNVYLQWKNNNYSSI--WCN 1060

  Fly   753 RNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMDRE 817
            .:||...||.......:.|:|.:.      :....|.|. .:|.::||..:.|..:.:.|.:...
Zfish  1061 DHFIHTKAMRKVREVRAQLKDIMV------QQKMNLISC-GSDWDVIRKCICAAYFHQAAKLKGI 1118

  Fly   818 NKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALAG 882
            .:...|..|.| ..:..:|.|.|.....|    :|::.|...|..:.  ::..|.|.|..:|..|
Zfish  1119 GEYVNVRTGMP-CHLHPTSALFGMGYTPD----YIIYHELVMTTKEY--MQCVTAVDGEWLAELG 1176

Fly 883 882
Zfish 1177 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	14/68 (21%)
		DEXDc	214..395	CDD:214692	65/180 (36%)
		DEXDc	226..368	CDD:238005	53/141 (38%)
		HELICc	479..575	CDD:197757	37/96 (39%)
		HA2	648..733	CDD:214852	25/84 (30%)
		OB_NTP_bind	783..884	CDD:285018	22/100 (22%)
dhx38	NP_957170.1	DEXDc	557..744	CDD:214692	69/190 (36%)
		DEXDc	580..718	CDD:238005	53/141 (38%)
		HELICc	793..892	CDD:197757	41/102 (40%)
		HA2	961..1043	CDD:214852	25/84 (30%)
		OB_NTP_bind	1077..1177	CDD:285018	24/114 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910