DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx57

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001178836.1	Gene:	Dhx57 / 366532	RGDID:	1310340	Length:	1391	Species:	Rattus norvegicus

Alignment Length:	978	Identity:	290/978 - (29%)
Similarity:	455/978 - (46%)	Gaps:	162/978 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 DFLQSCEPEKQLPGLTKAQRSHVHRLAQHRGLK------TVSKGPEENRVLFISRPQSDGQQQYI 133
            :|.::.||..........:.|.:.:|..|...|      .|...|.|.|   ||:|..  ::..|
  Rat   402 EFAKTSEPVVYSLITLLEEESEIVKLLTHTQHKYSVPPINVPPAPSETR---ISKPAY--RKPVI 461

  Fly   134 LCNTKLDICPPLLDVLGQMAGNVERRLMNSVGD----------LKCNKQQYKDIRLPSNFGLVGQ 188
            ..||.|.  ..:|:  |:....:|.......|.          :...|:.|:....|:. .|..:
  Rat   462 PSNTFLS--NQMLE--GEGLSELEEDADEDEGPAPIVVENESYVNLKKRSYRRCDRPAK-SLFAE 521

  Fly   189 -----RLIPPPQSNRN-RNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYIL 247
                 |.....|::|. ..|..||:.||.:::||:||.:|.:.||::|.|.||.||:||:||:||
  Rat   522 NSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQIPQFIL 586

  Fly   248 EWAAEHRAPVR---IVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTS 309
            : .:.:..|.|   |:.:|||||:||||:||::|||.|..|.||||.||:....||.|.|:..|:
  Rat   587 D-NSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTT 650

  Fly   310 GCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALS 374
            |.|||.|..|  :..:..||:|:||.|||..::|||||..|..:.:...|:::|||||:|....|
  Rat   651 GVLLRRLEGD--ATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRATLQVILMSATLDAGLFS 713

  Fly   375 NYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYM------HPRMEKFLGKP--------TGKETPS 425
            .||....|:.:.||:|.|..:.|||.|:.|.|:      :.|..|.:.|.        |..|...
  Rat   714 KYFSYCPVITIPGRAFPVDQFFLEDALAVTRYVLQDGSPYMRSMKQIAKERLKARHNRTALEEVE 778

  Fly   426 E----------------------------LLAAYYGGNTIV--------HPDIDNDLIVSLLELL 454
            |                            ||..|.|.:..|        ...::.:||.:|||.:
  Rat   779 EDLRLALHLQDEEESVKDTIPDQQLDFKQLLVRYKGVSKSVIKTMSVMDFEKVNLELIEALLEWI 843

  Fly   455 L---RQGDAGAVIVYLPGYSDMTSLLARLES-----SLPREQITIILLHSQVDNSEQRKVFRTYP 511
            :   .....||::|:|||.:::..|..:|:|     :....:..|..|||.:.:.||:.||...|
  Rat   844 VDGKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFVKPP 908

  Fly   512 GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRV 576
            ....|||:||||.:|||||.|::||||:|..|.|.||:......|..|::|||:|.||.||||||
  Rat   909 LGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRAGRV 973

  Fly   577 CHGNCYRLYD----NDRMARMNLYTIPEIMRRTLDEICLLTKLAA--PDKKIENFLALALDTPPK 635
            ..|.|:.|:.    |.::.:..|   |||.|..|:::||..|:..  ....:::..:..::.|..
  Rat   974 ASGVCFHLFTSHHYNHQLLKQQL---PEIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPHV 1035

  Fly   636 DAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRD 700
            |::..|..||:.||.|...:::||||:.:|.||:.|:|||.::.....||||..:.|||..:.:.
  Rat  1036 DSLRASKVRLRDLGALTPDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKS 1100

  Fly   701 PFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIG----DFCERNFICRNAM 761
            |||...::.:::.|:.....||.   ||.||::..|:.: .|..|:..    ::|.:||:....:
  Rat  1101 PFVSPWDKKEEANQKKLEFAFAN---SDYLALLCAYKGW-QLSTKESARASYNYCRQNFLSGRTL 1161

  Fly   762 EMFVSAASTLRDTVYRI------FRFSEASARL--------ASSFNNDTN-----MIRLALTAGL 807
            :...|......:.:..|      .|..|...|.        |:....:||     :|...|.|.|
  Rat  1162 QEMASLKRQFTELLSDIGFVKEGLRAKEIEKRAQGGDGVLDATGEEANTNAENPKLISAVLCAAL 1226

  Fly   808 YPKLAYMDR-ENKNQ-----------------LVAEGDPLVQVSRSSCLRGKKKQKDLASEWILF 854
            ||.:..:.. |.|.|                 .|.:.|..|.:..||.   ..:.:...|.::|:
  Rat  1227 YPNVVQVKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHIHPSSV---NYQVRHFDSPYLLY 1288

  Fly   855 VEKTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGSEMLLCL-DSWIRLKCPAEFGLQLHKV 918
            .||.:|:...  :...::||...:.|.||.:...:......::.| |.|||      |....|:|
  Rat  1289 HEKIKTSRVF--IRDCSMVSVYPLVLFGGGQVSVQLQRGAFVVSLDDGWIR------FVAASHQV 1345

  Fly   919 RML 921
            ..|
  Rat  1346 AEL 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	12/53 (23%)
		DEXDc	214..395	CDD:214692	84/183 (46%)
		DEXDc	226..368	CDD:238005	69/144 (48%)
		HELICc	479..575	CDD:197757	44/100 (44%)
		HA2	648..733	CDD:214852	31/84 (37%)
		OB_NTP_bind	783..884	CDD:285018	28/131 (21%)
Dhx57	NP_001178836.1	UBA_DHX57	184..221	CDD:270502
		RWD	249..422	CDD:399058	3/19 (16%)
		zf_CCCH_4	308..326	CDD:408151
		HrpA	504..1301	CDD:224557	254/812 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18934
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020