DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx35

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_006235485.1	Gene:	Dhx35 / 362260	RGDID:	1311165	Length:	703	Species:	Rattus norvegicus

Alignment Length:	704	Identity:	195/704 - (27%)
Similarity:	342/704 - (48%)	Gaps:	102/704 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 NIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILE--WAAEHRAPVRIVVSQ 263
            :|:.:|:.||::|.|..||.:::..|.::|.|.||.|||||:|||:.|  |.||.|.   :.|:|
  Rat    46 SIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQVPQYLAEAGWTAEGRV---VGVTQ 107

  Fly   264 PRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSS--NTVLMLTTSGCLLRALAMDKKSFFKN 326
            |||:||::|:.|::.|||...|..|||.||.: .|:.  .|.:...|.|.|:|.:.:|  .....
  Rat   108 PRRVAAVTVAGRVADERGAVLGHEVGYCIRFD-DCTDPLATRIKFLTDGMLVREMMVD--PLLTK 169

  Fly   327 TTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGG----------T 381
            .:.:::||||||.|.||..:...|...:|...|||::.|||:|.|...::|...          .
  Rat   170 YSVVMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQNETSDPARDTCV 234

  Fly   382 VMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDL 446
            ::.||||:|.|.|::|:..:                                      ||.....
  Rat   235 ILTVEGRTFPVDIFYLQSPV--------------------------------------PDYIKAT 261

  Fly   447 IVSLLELLLRQGDAGAVIVYLPGYSD---MTSLLARLESSLPR----EQITIILLHSQVDNSEQR 504
            :.:::::...:|| |.::.:|.|..:   :.|:|.....:|.|    :.:.::.:::.:.:.||.
  Rat   262 VDTVVKIHQTEGD-GDILAFLTGQEEVETVVSMLIEQARALARTGMKKHLRVLPMYAGLPSFEQM 325

  Fly   505 KVF-RTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQ 568
            ||| |....|| |:|::||:.:|||||..::||||.|..|::.|:.......|.:..:|||.|.|
  Rat   326 KVFERVSHSVR-KVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQ 389

  Fly   569 RAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIE-NFLALALDT 632
            ||||.||...|.|||||..:...::...|:||:.|..|..:.|..|....|..:. :|::    .
  Rat   390 RAGRGGRNRSGKCYRLYTEEAFEQLPQSTVPEMQRSNLAPVVLQLKALGIDSVLRFHFMS----P 450

  Fly   633 PPKDAVMQSCSRLKLLGVLDERDEVT-PLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYH 696
            ||..:::|:...|..||.||:...:| |||..:||.||.....|.|:.|....|...::.|||..
  Rat   451 PPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQEILSIAAMM 515

  Fly   697 SVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCERNFICRNAM 761
            .:::.||....: |....::.|.....:|  |.|.::.:||.|  :|......:|:.:|:....:
  Rat   516 QIQNVFVFPSNQ-KSQATRVHRKFAVEEG--DHLTMLNVYEAF--IKHNKSSQWCQEHFLNYKGL 575

  Fly   762 EMFVSAASTLRDTVYRI---FRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMDRENKNQLV 823
                ..|:|:||.:.::   |:..:.|:      ..|.:.:...:.:|.:...|........:.:
  Rat   576 ----VRAATVRDQLKKLLVKFQVPKMSS------EGDPDPVLRCIVSGFFANAARFHSTGAYRTI 630

  Fly   824 AEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTAD----QISSLEHTTLV 873
            .: |..:.:..:|.|..:|..:     |:::.|..:|:.    .::::|...|:
  Rat   631 RD-DHELHIHPASVLYAEKPPR-----WVIYNEVIQTSKYYMRDVTAIESAWLL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	72/194 (37%)
		DEXDc	226..368	CDD:238005	59/145 (41%)
		HELICc	479..575	CDD:197757	36/100 (36%)
		HA2	648..733	CDD:214852	26/85 (31%)
		OB_NTP_bind	783..884	CDD:285018	13/95 (14%)
Dhx35	XP_006235485.1	DEXDc	53..224	CDD:214692	69/176 (39%)
		DEXDc	73..211	CDD:238005	58/143 (41%)
		HELICc	301..396	CDD:197757	36/95 (38%)
		HA2	465..549	CDD:214852	26/86 (30%)
		OB_NTP_bind	584..683	CDD:285018	14/107 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810