DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and mle

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster

Alignment Length:	976	Identity:	283/976 - (28%)
Similarity:	462/976 - (47%)	Gaps:	144/976 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PEQA---------VVLVVNGRVTGGPKGTGKQKTRPGKNAKADAGDKLKSEDEKMLRQL-----V 73
            ||.|         .|..:|..||....|:.|      |:|.       ||....::|||     :
  Fly   194 PEHARSFLAELSIYVPALNRTVTARESGSNK------KSAS-------KSCALSLVRQLFHLNVI 245

  Fly    74 DDF---LQSCEPEKQLPGLTKAQRSHVHRL-----------AQHRGLKTVSKGPEENRVLFISR- 123
            :.|   |:..:.|:..|...|...:.::::           ...|.:|....||....::.:||
  Fly   246 EPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVVNPRNIKIELDGPPIPLIVNLSRI 310

  Fly   124 --PQSDGQQQYILCNTKLDICPPLLDVLGQMAGNVERRLM--NSVGDLKCN-KQQYKDIRLPSNF 183
              .|.||:::..  ::.:...||..:.....|.|::...:  .|:.||..: ::..:|.|
  Fly   311 DSSQQDGEKRQE--SSVIPWAPPQANWNTWHACNIDEGELATTSIDDLSMDYERSLRDRR----- 368

  Fly   184 GLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILE 248
                      ...|..|.....|..|||...|..||..:..:.|:||:|.||.||:||:.||||:
  Fly   369 ----------QNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQIAQYILD 423

  Fly   249 --WAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMN----RQCSSNTVLMLT 307
              ..:.......|.|:|||||:||||:||:::||.|..|.||||::|..    |...:   ::..
  Fly   424 DYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGA---ILFC 485

  Fly   308 TSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEA 372
            |.|.|||.|    ::..:..:|:|:||.||||:::||||:..:..:...|.|.::|||||:|...
  Fly   486 TVGVLLRKL----EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATIDTTK 546

  Fly   373 LSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSE--LLAA----- 430
            .|.|||...|::|.||:|.|..:.||||:..|.:: |..|   .:...||...|  ||:.
  Fly   547 FSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFV-PSAE---SRRKRKEVEDEEQLLSEDKDEA 607

  Fly   431 ----------YYGGNT------IVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLAR 479
                      .|...|      :...|:..:|:.:||..:..:...||::|:|||::.:.:|:..
  Fly   608 EINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLIFALMKF 672

  Fly   480 LESSL---PREQITIILLHSQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGL 541
            |:::.   ...|..|:..|||:...||||||...|....||||||||.:|||||.|:::|||...
  Fly   673 LQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILSTNIAETSITIDDIVFVIDICK 737

  Fly   542 AKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTL 606
            |:||.:.|..:.:.....|.|:.:.:||.||||||..|.|:.|....|...:.....||:.|..|
  Fly   738 ARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPL 802

  Fly   607 DEICLLTKLAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGV 671
            .|:.|..||.... .|.:||:.||:.||.|||:::...|:.:..||..||:||||.::|.||:..
  Fly   803 HEMALTIKLLRLG-SIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEP 866

  Fly   672 QIGKCLVYSIYLRCLDSMIIIAAYHSV-RDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKL 735
            ::||.:|......|.|.|.|:|:|.|. .:.|.|:|.:.:.:..|.:   .:|...||.:|:|..
  Fly   867 RLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKA---LSGTKCSDHVAMIVA 928

  Fly   736 YEEFTNLKRKDIGD-----FCERNFICRNAMEMFVSAASTLRDTVYRIFRFSE---ASARLASSF 792
            .:.:...|::  |:     ||:...:..:.|.:...|...|.|.:.:. .|.|   .|..:....
  Fly   929 SQMWRREKQR--GEHMEARFCDWKGLQMSTMNVIWDAKQQLLDLLQQA-GFPEECMISHEVDERI 990

  Fly   793 NNDTNMIRLALT---AGLYPKLAYMDRENKNQLVAEGD-PLVQVSRSSCLRGKKKQKDLA----S 849
            :.|..::.::|.   .||||.:. :.:|.:..|..|.. .|:..:..:|       .:||    .
  Fly   991 DGDDPVLDVSLALLCLGLYPNIC-VHKEKRKVLTTESKAALLHKTSVNC-------SNLAVTFPY 1047

  Fly   850 EWILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAEFGLQ 914
            .:.:|.||.||  :..|.:..::||.|.|.|.|.::....|:.   ::.:|:|:......|...:
  Fly  1048 PFFVFGEKIRT--RAVSCKQLSMVSPLQVILFGSRKIDLAANN---IVRVDNWLNFDIEPELAAK 1107

  Fly   915 L 915
            :
  Fly  1108 I 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	12/77 (16%)
		DEXDc	214..395	CDD:214692	76/186 (41%)
		DEXDc	226..368	CDD:238005	61/147 (41%)
		HELICc	479..575	CDD:197757	41/98 (42%)
		HA2	648..733	CDD:214852	29/85 (34%)
		OB_NTP_bind	783..884	CDD:285018	27/111 (24%)
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634	15/58 (26%)
		DEXDc	393..569	CDD:214692	75/182 (41%)
		DEXDc	402..542	CDD:238005	61/146 (42%)
		ATP-synt_B	<584..644	CDD:304375	10/62 (16%)
		Helicase_C	643..772	CDD:278689	51/128 (40%)
		HA2	842..926	CDD:214852	29/86 (34%)
		OB_NTP_bind	974..1078	CDD:285018	27/114 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12832at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850