DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Rhau

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001260639.1	Gene:	Rhau / 35339	FlyBaseID:	FBgn0032883	Length:	942	Species:	Drosophila melanogaster

Alignment Length:	949	Identity:	258/949 - (27%)
Similarity:	435/949 - (45%)	Gaps:	149/949 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NGRVTGGPKG-----TGKQKTRPGKNAKADAGDKLKSEDEKM---------------LRQLVDDF 76
            |.|....|.|     .|.......:..|.|.|:..:|::.::               :::|::|:
  Fly    11 NARKGNRPPGLRGKDIGLYYRNLARQQKKDRGENAESKEPQIRLGCNVSAPSGVLERVKELMEDY 75

  Fly    77 LQSCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGPEENRVLFISRPQSDGQQQYILCNTKLDI 141
              |..|.:|     .....:|....|.:....:|...||    |::..:..        |..||.
  Fly    76 --SRAPSRQ-----NVDDKNVDAKFQQQFRHLLSVNFEE----FVAETKER--------NADLDW 121

  Fly   142 CPPLLDVLGQMAGNVERRLMNSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHER 206
            ..|.||         ||..:.                       :|||.:   :.|..:.:: .|
  Fly   122 VNPKLD---------ERLQLE-----------------------LGQRQL---EENAKKRLE-AR 150

  Fly   207 RSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEH--RAPVRIVVSQPRRIAA 269
            :.||..|..:.|:..::.:||::|.|:||.||:||:||.:|:.|...  .:..||:.:|||||:|
  Fly   151 KKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPRRISA 215

  Fly   270 ISVSERISKERGEAPGTTVGYNIRM-NRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIID 333
            |:::|.:|.||.|:.|.:|||.||: :|:......:...|:|.||:.|..|  ....|.:.||:|
  Fly   216 IAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQLQSD--PLMHNLSVLILD 278

  Fly   334 EAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLE 398
            |.|||.::||.|:...|:.|...|.|:::|||||:..:...:||....:..:||..|.|.:.:||
  Fly   279 EIHERSVETDLLMGLLKVILPHRPDLKVILMSATVREQDFCDYFNNCPMFRIEGVMFPVKMLYLE 343

  Fly   399 DILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDI--------------------- 442
            |:||||.|   ..:||..:...::.|...:.    ...::.|.:
  Fly   344 DVLSKTNY---EFQKFRDRRPKRDPPERRMK----HEAMIEPYLRRIRNSYDSRVLDKLRLPESE 401

  Fly   443 ---DNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLP------REQITIILLHSQV 498
               |.|.|..|:..:......||::|:||||..::.|...|:....      |:.:.:..|||.:
  Fly   402 GCEDIDFIADLVYYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLHSLM 466

  Fly   499 DNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQ 563
            .:.||:.|||..|..:.|:|:||.|.:||:||.|::|||::|..|...||...:...|...|:::
  Fly   467 QSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSLDEVWVTK 531

  Fly   564 ADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLAL 628
            |:.:||.||||||..|.||.|:...|..||:....|||:|..|:.|.|..||...|... .||..
  Fly   532 ANTQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILRSKLESIILSLKLLHIDDPY-RFLQT 595

  Fly   629 ALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIA 693
            .::.|..:|:......||.:..||:...:||||..:|:||:..|:||.::.|....|||.:...|
  Fly   596 LINAPNPEAIKMGVELLKRIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAA 660

  Fly   694 AYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAV---IKLYEE--FTNLKRKDIGDFCER 753
            |..|.:.||...:  ||:|.....:...|.:..||.|.|   |..|.:  :::.:|    |||.:
  Fly   661 AALSFKSPFYSPL--GKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAER----DFCYK 719

  Fly   754 NFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTN--MIRLALTAGLYPKLAYM-- 814
            ||:....::......:...:.:|.....:.::.:.|:|..|...  ::|..:.|||||.:|::
  Fly   720 NFLSSMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGAGLYPNMAHLRK 784

  Fly   815 DRENKNQ------LVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLV 873
            .|:.||:      :..:....|....||...|   :....|.:.::.::.::.|..  |..:|:|
  Fly   785 SRQIKNRVRAIHTMATDDGRRVNFHPSSVNSG---ESGFDSAYFVYFQRQKSTDLF--LLDSTMV 844

  Fly   874 --SGLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAE 910
              ..|::...|.:..:|:   :...||:......||..|
  Fly   845 FPMALIIFGDGVEAGVTQ---NTPYLCVAKTYYFKCNRE 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	11/73 (15%)
		DEXDc	214..395	CDD:214692	68/183 (37%)
		DEXDc	226..368	CDD:238005	60/144 (42%)
		HELICc	479..575	CDD:197757	36/101 (36%)
		HA2	648..733	CDD:214852	29/87 (33%)
		OB_NTP_bind	783..884	CDD:285018	24/112 (21%)
Rhau	NP_001260639.1	DEXDc	147..328	CDD:214692	68/183 (37%)
		DEXDc	170..312	CDD:238005	59/143 (41%)
		Helicase_C	411..544	CDD:278689	46/132 (35%)
		HA2	614..696	CDD:214852	27/83 (33%)
		OB_NTP_bind	735..853	CDD:285018	24/122 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12832at50557
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850