DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and dhx16

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_956318.1	Gene:	dhx16 / 336645	ZFINID:	ZDB-GENE-030131-8589	Length:	1054	Species:	Danio rerio

Alignment Length:	966	Identity:	263/966 - (27%)
Similarity:	422/966 - (43%)	Gaps:	189/966 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DSEEAVKRGRRQGRKKAQPMPEQAVVLVVNGRVTGGPKGTGKQKT-----RPGKNAKADAGDKLK 62
            :.||..:||.|:   :.|.:.|:....   .||    |...|.||     |..|.|..:|..::|
Zfish   161 EEEEEWERGERE---RLQDLEERDAFA---ERV----KQKDKDKTRNILERNDKKAYEEAQKRIK 215

  Fly    63 SEDE---KML----RQLVDDFLQSCEPEK---------------QLPGLTKAQRSHVHRLAQHRG 105
            ..:|   |||    :|....:|...|.||               ....||..:|..   |...|.
Zfish   216 MAEEDKRKMLPELRKQSRRQYLSKREQEKLEDLEAEIKDEEYLFSTQNLTDRERKD---LEYKRT 277

  Fly   106 LKTVSK-----GPEENRVLFISRPQSDGQQQYILCNTKLDICPPLLDV-----------LGQMAG 154
            ::.::|     |.:|         |.:.:.:|.:...|.:...|..|:           .|:...
Zfish   278 IRDMAKEYKKAGAKE---------QEERKNRYYMPEEKRNKSIPQKDMDLEFEETPREGGGEQGR 333

  Fly   155 NVERRLMNSVGDLKCNKQQYKDIRLPSN-----------------------FGLVGQRLIPPPQS 196
            ..|.|:  :...|:...:|.::.|:...                       .|.:.::...|..|
Zfish   334 WEEARV--ATATLQFGARQERERRIKEEQERYQLILEEEEMITFVSTAITMKGTLSEKESEPELS 396

  Fly   197 ---NRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVR 258
               .:.::||..||||||:..||.:|..:...|:|:|:|.|||||:||:|||:|| ....:..::
Zfish   397 QAEKQKQSIQEVRRSLPIFPYREDLLAAIGDHQILVIEGETGSGKTTQIPQYLLE-EGYTKGGMK 460

  Fly   259 IVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAM--DKK 321
            |..:||||:||:||:.|:::|.....|..|||:||.....|..|:|...|.|.|||....  |..
Zfish   461 IGCTQPRRVAAMSVAARVAQEMSVKLGNEVGYSIRFEDCTSERTILKYMTDGMLLREFLTEPDLA 525

  Fly   322 SFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVE 386
            |:    :.:||||||||.|.||.|....|...:..|.|::::.|||:|.|..|::|....|..:.
Zfish   526 SY----SVIIIDEAHERTLHTDILFGLIKDIARFRPDLKVLVASATLDTERFSSFFDDAPVFRIP 586

  Fly   387 GRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLL 451
            ||.|.|.||:.                       |...::.|.|               .:||:|
Zfish   587 GRRFPVDIYYT-----------------------KAPEADYLEA---------------CVVSVL 613

  Fly   452 ELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPR-----EQITIILLHSQVDNSEQRKVFR-TY 510
            ::.:.| ..|.|:|:|.|..::.:....|:....|     .::.::.:::.:.:..|.|:|. |.
Zfish   614 QIHVTQ-SPGDVLVFLTGQEEIEACCELLQERCRRLGSKISELLVLPIYANLPSDMQAKIFNPTP 677

  Fly   511 PGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGR 575
            ||.| |::::|||.:||:||..::||||.|..|.|:|::......|.:|..|:|.|.||||||||
Zfish   678 PGAR-KVVVATNIAETSLTIDGIIYVIDPGFCKQKSYNAKTGMESLIVTPCSRASANQRAGRAGR 741

  Fly   576 VCHGNCYRLYDNDRMA-RMNLYTIPEIMRRTLDEICLLTK-LAAPDKKIENFLALALDTPPKDAV 638
            |..|.|:|||...... .|...|:|||.|..|..:.||.| |...|....:|    :|.||.:.:
Zfish   742 VAAGKCFRLYTAWAFKHEMEETTVPEIQRTNLGNVVLLLKSLGINDLIHFDF----MDPPPHETL 802

  Fly   639 MQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFV 703
            :.:..:|..||.|:...|:|.||..:||||:...:.|.::.|...:|.:.::.|||..||.:. :
Zfish   803 VLALEQLYALGALNHLGELTKLGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLSVNNS-I 866

  Fly   704 LNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIG---DFCERNFICRNAMEMFV 765
            ....:.|......:|:.|...| .|.|.::.:|.::.     :.|   .:|..|||...:|:...
Zfish   867 FYRPKDKVVHADNARMNFVVPG-GDHLVLLNVYTQWV-----ESGYSTQWCFENFIQFRSMKRAR 925

  Fly   766 SAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMDR-------------E 817
            .....|...:.||      ...|.|| |.|:..||.|:|||.:...|.:.:             .
Zfish   926 DVRDQLEGLMDRI------EVELCSS-NGDSMPIRKAVTAGYFYHTARLSKGGYKTVKHQQTVYV 983

  Fly   818 NKNQLVAEGDPLVQVSRSSCLRGKKKQK---DLASEWILFVE----KTRTADQISS 866
            :.|..:.|..|...:........|:..:   ::.|.|:|.|.    |.:..:..||
Zfish   984 HPNSSLFEEQPRWMIYHELVFTTKEFMRQVIEIESGWLLEVAPHYYKNKELEDSSS 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	17/85 (20%)
		DEXDc	214..395	CDD:214692	73/182 (40%)
		DEXDc	226..368	CDD:238005	60/143 (42%)
		HELICc	479..575	CDD:197757	36/101 (36%)
		HA2	648..733	CDD:214852	25/84 (30%)
		OB_NTP_bind	783..884	CDD:285018	23/104 (22%)
dhx16	NP_956318.1	BLVR	<94..>142	CDD:283923
		GBP_C	<177..296	CDD:303769	30/137 (22%)
		coiled coil	271..285	CDD:293879	3/16 (19%)
		DEXDc	407..594	CDD:214692	79/191 (41%)
		DEXDc	429..568	CDD:238005	60/143 (42%)
		Helicase_C	612..742	CDD:278689	44/131 (34%)
		HA2	811..895	CDD:214852	25/85 (29%)
		OB_NTP_bind	916..1028	CDD:285018	25/118 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810