DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and l(1)G0007

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	240/930 - (25%)
Similarity:	398/930 - (42%)	Gaps:	186/930 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GGPKG----TGKQKTRPGKNAKADAGDKLKSEDEKM-------------LRQLVDDFLQSCEPEK 84
            |||..    ..:::....:..:..|..:..:.|.::             |..:.|||     .|:
  Fly   340 GGPNSEYFRKREEQLEQKRTKRISAQQRQNNRDNELWERNRMLTSGVVTLISVNDDF-----DEE 399

  Fly    85 QLPGLTKAQRSHVHRLAQH------RGLKTVSKGPEENRVLFISRPQSD---------------- 127
            .|        ..||.|..|      .|....:|.||.  |:.:..|.||
  Fly   400 AL--------ERVHLLVHHIIPPFLDGRIVFTKQPEP--VVPVKDPTSDMALLARKGSALVRNYR 454

  Fly   128 --------GQQQYILCNTKLDICPPLLDVLGQMAGNVERRLMNSVGDLKCNKQQYK-DIRLPSNF 183
                    .::.:.|..||          ||.:.| |:|  .....|::.:|::.| |.|....|
  Fly   455 EQKERRKAQKKHWELSGTK----------LGNIMG-VQR--PQDEDDMRFDKEKDKADYRKDQKF 506

  Fly   184 G--LVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYI 246
            .  :..|........:|.:.|..:||.||::..|:.:|||::.:.|:||.|.|||||:|||.||:
  Fly   507 ADHMRDQDTGGKSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYL 571

  Fly   247 LEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGC 311
            .|.....|.  .|..:||||:||:||::|:|.|.....|..|||.||.....|..||:...|.|.
  Fly   572 HEDGYSKRG--MIGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGI 634

  Fly   312 LLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNY 376
            |||....|.:  ..:.:.:|:||||||.|.||.|....:..:.:...|:|::.|||||....:.:
  Fly   635 LLRESLRDPE--LDSYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATF 697

  Fly   377 FGGGTVMDVEGRSFEVSIY--------HLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYG 433
            ||......:.||:|.|.:.        ::|..:.:...:|             .||:|
  Fly   698 FGNVPTFTIPGRTFPVDVMFSKNTCEDYVESAVKQALQVH-------------LTPNE------- 742

  Fly   434 GNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPR----EQITIILL 494
                                       |.:::::||..|:......||..|..    ..::|:.:
  Fly   743 ---------------------------GDMLIFMPGQEDIEVTCEVLEERLAEIDNAPALSILPI 780

  Fly   495 HSQVDNSEQRKVF-RTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTL 558
            :||:.:..|.|:| ::..|:| |.:::|||.:||:|:..::||||:|..|:|.|:..|....|.:
  Fly   781 YSQLPSDLQAKIFQKSSDGLR-KCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQI 844

  Fly   559 TWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNL--YTIPEIMRRTL-DEICLLTKLAAPDK 620
            ..||||:|.||:|||||...|..|||| ..|..:..|  .|:|||.|..| :.:.||..|...|.
  Fly   845 YPISQANANQRSGRAGRTGPGQAYRLY-TQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDL 908

  Fly   621 KIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRC 685
            ...:|    :|.||:|.::.|..:|.:||.||....:|.||..:||.||.....:.|:.:..:.|
  Fly   909 LQFHF----MDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGC 969

  Fly   686 LDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGM--------SDSLAVIKLYEEFTNL 742
            ...::||.:..||  |.:....:|::.         ..||:        ||.|..:.:|:::.
  Fly   970 SAEVLIIVSMLSV--PSIFYRPKGRED---------EADGVREKFQRPESDHLTYLNVYQQWR-- 1021

  Fly   743 KRKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGL 807
            :......:|..:||...||.........|:|.:      ::.:..:.|. ..|.:::|..:.:..
  Fly  1022 QNNYSSTWCNEHFIHIKAMRKVREVRQQLKDIM------TQQNLSVISC-GIDWDIVRKCICSAY 1079

  Fly   808 YPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTL 872
            :.:.|.:....:...:..|.| ..:..:|.|.|.....|    ::::.|...||.:.  ::..|.
  Fly  1080 FYQAARLKGIGEYVNLRTGMP-CHLHPTSALYGLGTTPD----YVVYHELIMTAKEY--MQCATA 1137

  Fly   873 VSGLMVALAGGKRFITEAHG 892
            |.|..:|..|...|..:..|
  Fly  1138 VDGYWLAELGPMFFSVKESG 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	16/77 (21%)
		DEXDc	214..395	CDD:214692	71/180 (39%)
		DEXDc	226..368	CDD:238005	58/141 (41%)
		HELICc	479..575	CDD:197757	38/100 (38%)
		HA2	648..733	CDD:214852	24/92 (26%)
		OB_NTP_bind	783..884	CDD:285018	18/100 (18%)
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	75/189 (40%)
		DEXDc	551..689	CDD:238005	58/141 (41%)
		HELICc	722..870	CDD:238034	51/195 (26%)
		HA2	932..1014	CDD:214852	24/92 (26%)
		OB_NTP_bind	1048..1148	CDD:285018	19/113 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840