DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Tdrd9

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_017450003.1	Gene:	Tdrd9 / 299343	RGDID:	1306942	Length:	1396	Species:	Rattus norvegicus

Alignment Length:	855	Identity:	236/855 - (27%)
Similarity:	383/855 - (44%)	Gaps:	167/855 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MLRQLVDDFLQ------SCEPEKQLPGL-----TKAQRSHVHRLAQHRGLKTVSKGPEENRVLFI 121
            |||:|..|.:.      ......:|.||     .:|.|..|.|..:.......::..:..:...:
  Rat     1 MLRKLTVDQINDWFTIGKTVTNVELLGLPPAFPAEAPREEVQRSEEVPSEAPTAQAQDPVKATAL 65

  Fly   122 SRP---------QSDGQQQYILCNTKLDICPPLLDVLGQ---MAGNVERRLMNSVGDLKCNKQQY 174
            :||         |...:.:||  |....:....||:.||   .:|...|..:..:.::.|
  Rat    66 ARPASAFGRSLSQRSSEVEYI--NKYRQLEAQELDIYGQDQPPSGPGLRSPLAKISNVAC----- 123

  Fly   175 KDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKS 239
                            ||        ...::...|||.:.:|.::::::.:.|:||.||||||||
  Rat   124 ----------------IP--------ETTYKYPDLPINRCKEEVISLIESNSVVIIHGATGSGKS 164

  Fly   240 TQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVL 304
            ||||||:|:...:..|...|||:|||:|.|.|::..|||||....|..|||.:.:.:..:.:|.|
  Rat   165 TQLPQYVLDHYTQRSAFCNIVVTQPRKIGASSIARWISKERSWTLGGLVGYQVGLEKTATEDTRL 229

  Fly   305 MLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPH-LRLVLMSATM 368
            :..|:|.||:.:...|.  ....||:.|||.|||..:.|||||..:..|:.|.. ::::|||||:
  Rat   230 IYMTTGVLLQKIVSAKS--LMEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVILMSATI 292

  Fly   369 DLEALSNYF--------GGGTVMDVEGRSFEVSIYHLEDI--LSKTGYMHPRMEKFLGKPTGKET 423
            :.:..::||        ....|.:|||:...:..|:|.|:  :..:|....|:|:
  Rat   293 NCKQFADYFAVPVQNKMNPAYVFEVEGKPHTIEQYYLNDLGHIYHSGLPPYRLEE---------- 347

  Fly   424 PSELLAAYYGGNTIVHPDIDNDLIVSLLELL--LRQGDAG--------------AVIVYLPGYSD 472
                        .::..|: .::.|||:::.  |...::|              :|:|:|||..:
  Rat   348 ------------PVITKDV-YEVAVSLIQMFDDLDMKESGNKTWSGAQFVSERSSVLVFLPGLGE 399

  Fly   473 MTSLLARLESSLPREQITIILLHSQVDNSEQRKVFRT-YPGVRLKIILSTNIGQTSITIPDLLYV 536
            : :.:..|.:::..:::.:..|||.|...||..||.: .||.| ||||||||.::|:|:||:.||
  Rat   400 I-NYMHELLTNMIHKRLQVYPLHSSVTLEEQNNVFLSPVPGYR-KIILSTNIAESSVTVPDVKYV 462

  Fly   537 IDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRM-ARMNLYTIPE 600
            ||..|.:....|...:...|.|:|.|:....||.||||||..|.||||...|.. :.:..:.:||
  Rat   463 IDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRAGRVSKGYCYRLIHRDFWDSAIPDHVVPE 527

  Fly   601 IMRRTLDEICLLTKLAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVL-------DER---D 655
            ::|..|....|..||....:. ...||.||..|....:.::...||.:|.|       ||.   .
  Rat   528 MLRCPLGSTVLKVKLLDMGEP-RALLATALSPPSLSDIERTILLLKEVGALAVSGQREDENPHDG 591

  Fly   656 EVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVL 720
            |:|.||.::|:||:..|:||.:|......|||..:||||..|:::.|.:.. |....|.: ::|.
  Rat   592 ELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIAAALSLKNFFTMPF-RQHLDGYR-NKVH 654

  Fly   721 FAGDGMSDSLAVIKLYEEFTNLKR-------KDIGDFCERNFI----CRNAME------------ 762
            |:|...||.||:::.:..:...::       ||..|:...|:|    .|...|
  Rat   655 FSGSSRSDCLALVEAFRAWQACRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKNRISQF 719

  Fly   763 -MFVSAASTLRDTVYRI-FRFSEASARLASSFNNDTNMIRLALTAGLYPK---LAYMDRENKNQL 822
             |||.....:.|..|.. .||                ::::.|....||.   ....|.|...:.
  Rat   720 NMFVDPRHPVLDQEYPYKQRF----------------ILQVVLAGAFYPNYFTFGQPDEEMAVRE 768

  Fly   823 VAEGDPLVQV 832
            :|..||...|
  Rat   769 LAGRDPKTTV 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	12/65 (18%)
		DEXDc	214..395	CDD:214692	71/189 (38%)
		DEXDc	226..368	CDD:238005	63/142 (44%)
		HELICc	479..575	CDD:197757	39/96 (41%)
		HA2	648..733	CDD:214852	33/94 (35%)
		OB_NTP_bind	783..884	CDD:285018	9/53 (17%)
Tdrd9	XP_017450003.1	DEXDc	146..327	CDD:214692	70/182 (38%)
		DEXDc	151..292	CDD:238005	63/142 (44%)
		Helicase_C	385..502	CDD:278689	45/118 (38%)
		HA2	590..667	CDD:214852	29/78 (37%)
		TUDOR	924..1026	CDD:278965
		TUDOR	962..1009	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920