DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx38

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_006255639.1	Gene:	Dhx38 / 292007	RGDID:	1310345	Length:	1227	Species:	Rattus norvegicus

Alignment Length:	908	Identity:	247/908 - (27%)
Similarity:	413/908 - (45%)	Gaps:	135/908 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEEAVKRGRRQGRKKAQPMPEQAVVLVVNGRVTGGPKGTGKQKTRPGKNAKADAG-------DKL 61
            ||:.|:|..:...|:.|.            |::...:...:...|...|....:|       |:.
  Rat   344 SEDYVRRREQHLHKQKQK------------RISAQRRQINEDNERWETNRMLTSGVVHRLEVDED 396

  Fly    62 KSEDEK-----MLRQLVDDFLQ-----SCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGPEEN 116
            ..||..     |:..||..||.     :.:||..:|  .|...|.:..:|: :|.:||.|..|:.
  Rat   397 FEEDNAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIP--VKDATSDLAIIAR-KGSQTVRKHREQK 458

  Fly   117 RVLFISRPQSDGQQQYILCNTKLDICPPLLDVLGQMAGNVERRLMNSVGDLKCNKQQYKDIRLPS 181
                 .|.::. .:.:.|..|||.      |::|........:.|...|.:        |.|...
  Rat   459 -----ERRKAQ-HKHWELAGTKLG------DIMGVKKEEEPDKAMTEDGKV--------DYRTEQ 503

  Fly   182 NFG-LVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQY 245
            .|. .:.::.....:..:.::|..:|:.|||:..::.:|.:::.:.::|:.|.|||||:|||.||
  Rat   504 KFADHMKEKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQY 568

  Fly   246 ILEWAAEHRAPV----RIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLML 306
            :      |:...    .|..:||||:||:||::|:|:|.|...|..|||.||.....|.||::..
  Rat   569 L------HQDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENTLIKY 627

  Fly   307 TTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLE 371
            .|.|.|||...  :::...:.:.:|:||||||.|:||.|....:..:.:...|:|::.|||||.:
  Rat   628 MTDGILLRESL--READLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAD 690

  Fly   372 ALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNT 436
            ..:.:||...:..:.||:|.|.|     :.||                   ||.|         .
  Rat   691 KFAAFFGNVPIFHIPGRTFPVDI-----LFSK-------------------TPQE---------D 722

  Fly   437 IVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSD--MTS--LLARLESSLPREQITIILLHSQ 497
            .|...:...|.|.|      .|..|.:::::||..|  :||  ::..||.......:.::.::||
  Rat   723 YVEAAVKQSLQVHL------SGAPGDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQ 781

  Fly   498 VDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWI 561
            :.:..|.|:|:..| ||| |.|::|||.:||:|:..:::|||:|..|:|.::..|....|.:..|
  Rat   782 LPSDLQAKIFQKAPDGVR-KCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPI 845

  Fly   562 SQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNL-YTIPEIMRRTLDEICLLTK-LAAPDKKIEN 624
            |||:|.||:|||||...|.|:|||.........| .|:|||.|..|..:.||.| |...|....:
  Rat   846 SQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFH 910

  Fly   625 FLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSM 689
            |    :|.||:|.::.|..:|.:||.||....:|..|.::.|.||...:.|.|:.|..:.|...:
  Rat   911 F----MDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEI 971

  Fly   690 IIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCERN 754
            ::|.:..||  |.:....:|::......|..||.. .||.|..:.:|.::.|.....|  :|..:
  Rat   972 LLIVSMLSV--PAIFYRPKGREEESDQIREKFAVP-ESDHLTYLNVYLQWKNNNYSTI--WCNDH 1031

  Fly   755 FICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMDRENK 819
            ||...||.......:.|:|.:.: .|.|.||.      ..|.:::|..:.|..:.:.|.:....:
  Rat  1032 FIHAKAMRKVREVRAQLKDIMVQ-QRMSLASC------GTDWDIVRKCICAAYFHQAAKLKGIGE 1089

  Fly   820 NQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALAG 882
            ...:..|.| ..:..:|.|.|.....|    :|::.|...|..:.  ::..|.|.|..:|..|
  Rat  1090 YVNIRTGMP-CHLHPTSSLFGMGYTPD----YIVYHELVMTTKEY--MQCVTAVDGEWLAELG 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	18/68 (26%)
		DEXDc	214..395	CDD:214692	65/184 (35%)
		DEXDc	226..368	CDD:238005	55/145 (38%)
		HELICc	479..575	CDD:197757	37/96 (39%)
		HA2	648..733	CDD:214852	24/84 (29%)
		OB_NTP_bind	783..884	CDD:285018	20/100 (20%)
Dhx38	XP_006255639.1	DUF3984	<190..>299	CDD:289881
		DEXDc	526..713	CDD:214692	69/194 (36%)
		DEXDc	551..687	CDD:238005	55/143 (38%)
		HELICc	758..861	CDD:197757	39/103 (38%)
		HA2	930..1012	CDD:214852	24/84 (29%)
		OB_NTP_bind	<1063..1146	CDD:285018	18/90 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810