DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx33

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001099272.1	Gene:	Dhx33 / 287464	RGDID:	1307239	Length:	698	Species:	Rattus norvegicus

Alignment Length:	720	Identity:	210/720 - (29%)
Similarity:	336/720 - (46%)	Gaps:	107/720 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 GQRLIPP---PQSNRNRN-IQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYIL 247
            |:|..||   |.::..|. ::.:||||||::.|..:|..|:.....::.|.|||||:||:|||:.
  Rat    39 GRRQTPPLAQPSASPYREALELQRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLY 103

  Fly   248 EWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCL 312
            |.....:.  .|.|:||||:||||::.|:|.|:....|..|||.:|.....|.:|.:...|.|.|
  Rat   104 EGGISRQG--IIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGML 166

  Fly   313 LRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKL------ELQKNPHLRLVLMSATMDLE 371
            ||....|  |..:..:.:|:||||||.:.||.|....|.      ||.|.| |::::||||||::
  Rat   167 LREAISD--SLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLP-LKVIVMSATMDVD 228

  Fly   372 ALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNT 436
            ..|.||.|..|:.:|||...:.|::.:.  .:..|:|                    ||
  Rat   229 LFSQYFNGAPVLYLEGRQHPIQIFYTKQ--PQQDYLH--------------------AA------ 265

  Fly   437 IVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSD---MTSLLARLESSLPR--EQITIILLHS 496
                      :||:.::......:..::|:|.|..:   |:.....:...||.  ..:.::.|::
  Rat   266 ----------LVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPSMLVLPLYA 320

  Fly   497 QVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWI 561
            .:..|:|.:||:..|....|:|:||||.:|||||..:.||:|||:.|.|.|:.......|.:..:
  Rat   321 SLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRV 385

  Fly   562 SQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFL 626
            |:..|.||.|||||...|.|||||..|...:......|||.|..|..:.|  :|.|  .|:.|.|
  Rat   386 SKTQAWQRTGRAGREDSGICYRLYTEDEFDKFEKMAAPEIQRCNLASVML--QLLA--MKVPNVL 446

  Fly   627 AL-ALDTPPKDAVMQSCSRLKLLGVLDERDE---VTPLGHIVAELPLGVQIGKCLVYSIYLRCLD 687
            .. .:..|..|.:..:.::|.|||.|:.:|:   :||:|..:|..||..:..|.::.|....|.:
  Rat   447 TFDFMSRPSPDHIEAAIAQLDLLGALEHKDDQLALTPIGRKMAAFPLEPKFAKTILLSSKFHCTE 511

  Fly   688 SMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIG---D 749
            .::.|.:..|| |..:.|....:...|.:.:...:.:|  |.:.::.:|..|     |:||   |
  Rat   512 EILTIVSLLSV-DSVLYNPPARRDEVQSVRKKFISSEG--DHITLLNIYRTF-----KNIGGNKD 568

  Fly   750 FCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLAL-------TAGL 807
            :|:.||:....|.:.....:.|||...::      |..:.|| ..|...:|..|       ||.|
  Rat   569 WCKENFVNSKNMLLVAEVRAQLRDICLKM------SMPIMSS-RGDMESVRRCLAHSLFMSTAEL 626

  Fly   808 YPKLAYMDRENKNQLVAEGDPLVQVSRSSCL-------RGKKKQKDLA---SEWI------LFVE 856
            .|...|...:....:......::...:.:|:       ..|...:||.   :||:      .|..
  Rat   627 QPDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAPDYFRR 691

  Fly   857 KTRTA 861
            |.|||
  Rat   692 KLRTA 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	72/186 (39%)
		DEXDc	226..368	CDD:238005	58/147 (39%)
		HELICc	479..575	CDD:197757	35/97 (36%)
		HA2	648..733	CDD:214852	21/87 (24%)
		OB_NTP_bind	783..884	CDD:285018	22/102 (22%)
Dhx33	NP_001099272.1	DEXDc	49..252	CDD:214692	80/207 (39%)
		DEXDc	83..225	CDD:238005	58/146 (40%)
		Helicase_C	282..399	CDD:278689	39/116 (34%)
		HA2	469..554	CDD:214852	21/87 (24%)
		OB_NTP_bind	588..688	CDD:285018	20/106 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810