DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8915 and Ythdc2

DIOPT Version :10

Sequence 1:NP_573208.1 Gene:CG8915 / 32715 FlyBaseID:FBgn0030833 Length:976 Species:Drosophila melanogaster
Sequence 2:NP_001156485.1 Gene:Ythdc2 / 240255 MGIID:2448561 Length:1445 Species:Mus musculus


Alignment Length:1128 Identity:309/1128 - (27%)
Similarity:502/1128 - (44%) Gaps:260/1128 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 GGPKGTGKQKTRPGKNAKADAGDKLKSEDEKML--RQLVDDFLQSCEPEKQLP-GLTKAQRSHVH 98
            ||..|.|.....||...:|.....::.::|..:  ...::.|....:.|.:.| .||..:|:.:|
Mouse    30 GGGGGGGPASCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIH 94

  Fly    99 RLAQHRGLKTVSKGPEENRVLFISRPQSDGQQ---QYILCNTKLDICPPLLDVLGQM-AGNVERR 159
            ||:|..||.:.|||...||.|.:.:  .||.:   ..:.||...:....:..::.:. ..|.||.
Mouse    95 RLSQSLGLVSKSKGKGANRYLTVKK--KDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERT 157

  Fly   160 LM---NSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNV 221
            .:   ...|::...:.:.:::...|  |.:...:...|...........|:|||:::::|.|:.:
Mouse   158 ELLPKTERGNVFAVEAENREMSKTS--GRLNNGIPQVPVKRGESEFDSFRQSLPVFEKQEEIVKI 220

  Fly   222 LQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGT 286
            ::.::|::|.|.|||||:||:||::|:...::..|.||..:||||:|||:|:||::.||.|..|.
Mouse   221 IKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQ 285

  Fly   287 TVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKL 351
            |:||.||:..:.|..|:|...|:|.|||.| |...|.....||:|:||.||||..:||||  |||
Mouse   286 TIGYQIRLESRVSPKTLLTFCTNGVLLRTL-MAGDSTLSTVTHVIVDEVHERDRFSDFLL--TKL 347

  Fly   352 E--LQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKF 414
            .  |||:|.|:|:|.||.:|:.....|||...|:.::||.|||....|||||..|||.:..|.|:
Mouse   348 RDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKY 412

  Fly   415 LGKPTGKETPSELLAAYY-----------------------------GGNTI------------- 437
            ..:...:|.....|..:|                             ||:.:             
Mouse   413 KKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLE 477

  Fly   438 ---------------VHPDIDN------------------------------------------- 444
                           :|.|:|.                                           
Mouse   478 PWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQVEQLI 542

  Fly   445 ----------------------------------------------------------------- 444
                                                                             
Mouse   543 SMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAEDRELL 607

  Fly   445 --------------DLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPR-----EQIT 490
                          |||:.||..:....||||::::||||.::..|..|:.....|     .:..
Mouse   608 KAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQ 672

  Fly   491 IILLHSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDAS 554
            :.:|||.:..|:|:||.:..| ||| ||||||||.:||||:.|:::|||:|..|.|::|:....:
Mouse   673 VFMLHSNMQTSDQKKVLKNPPAGVR-KIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVT 736

  Fly   555 QLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAP- 618
            .|.:.|||:|.|.||.|||||...|.|:||:...|...|..:..||::|..|.|:||.|||.|| 
Mouse   737 MLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPV 801

  Fly   619 DKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYL 683
            :..|.:||..|.:.||...|..:...||.:..:|..:::|.||:.:|:||:...:||.::.::.|
Mouse   802 NCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVL 866

  Fly   684 RCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIG 748
            :|||.::.||...:.||||||..:..:|....:.|..|.....||.:|:::.::.:.  |.:..|
Mouse   867 KCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQ--KARSDG 929

  Fly   749 ---DFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEA----SARLASSFNNDTNMIRLALTAG 806
               .|||:||:.:..||:.:...:.|...: |...|..|    ..|..::.:.:..:::.||.||
Mouse   930 WERAFCEKNFLSQATMEIIIGMRTQLLGQL-RASGFVRARGGGDIRDVNTNSENWAVVKAALVAG 993

  Fly   807 LYPKLAYMDRENKNQLVAEG--DPLVQVSRSSCLRGKKKQK------------DLASEWILFVEK 857
            :||.|.::||||   ::..|  :..|:...:|.|...:.:|            .|.::|:::.|.
Mouse   994 MYPNLVHVDREN---VILTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEM 1055

  Fly   858 TRTADQISSLEHTTLVSGLMV-ALAGGKRFITEA----------------HGSEM---------L 896
            || |.:|:::...:.|:.:.| ...|..|..:.|                ..|||         .
Mouse  1056 TR-AHRIANIRCCSAVTPVTVLVFCGPARLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAA 1119

  Fly   897 LCLDSWIRLKCPAEFGLQLHKVR 919
            |.||.|:..|...|....|.::|
Mouse  1120 LKLDEWLNFKLEPEAASLLLQLR 1142

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8915NP_573208.1 R3H 67..123 CDD:460206 18/58 (31%)
HrpA 208..>702 CDD:441249 208/681 (31%)
OB_NTP_bind 799..884 CDD:400182 26/99 (26%)
Ythdc2NP_001156485.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50 7/19 (37%)
R3H_DEXH_helicase 61..119 CDD:100077 18/57 (32%)
PRK11131 203..>1033 CDD:182986 249/839 (30%)
DEXHc_YTHDC2 208..383 CDD:350745 80/177 (45%)
DEAH box 331..334 2/2 (100%)
ANK repeat 520..552 CDD:293786 0/31 (0%)
ANK 1 521..553 0/31 (0%)
ANK 2 554..586 0/31 (0%)
ANK repeat 554..582 CDD:293786 0/27 (0%)
SF2_C_RHA 612..767 CDD:350178 63/155 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1179..1303
YTH 1304..1433 CDD:410979
Blue background indicates that the domain is not in the aligned region.

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