DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Ythdc2

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001156485.1	Gene:	Ythdc2 / 240255	MGIID:	2448561	Length:	1445	Species:	Mus musculus

Alignment Length:	1128	Identity:	309/1128 - (27%)
Similarity:	502/1128 - (44%)	Gaps:	260/1128 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GGPKGTGKQKTRPGKNAKADAGDKLKSEDEKML--RQLVDDFLQSCEPEKQLP-GLTKAQRSHVH 98
            ||..|.|.....||...:|.....::.::|..:  ...::.|....:.|.:.| .||..:|:.:|
Mouse    30 GGGGGGGPASCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIH 94

  Fly    99 RLAQHRGLKTVSKGPEENRVLFISRPQSDGQQ---QYILCNTKLDICPPLLDVLGQM-AGNVERR 159
            ||:|..||.:.|||...||.|.:.:  .||.:   ..:.||...:....:..::.:. ..|.||.
Mouse    95 RLSQSLGLVSKSKGKGANRYLTVKK--KDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERT 157

  Fly   160 LM---NSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNV 221
            .:   ...|::...:.:.:::...|  |.:...:...|...........|:|||:::::|.|:.:
Mouse   158 ELLPKTERGNVFAVEAENREMSKTS--GRLNNGIPQVPVKRGESEFDSFRQSLPVFEKQEEIVKI 220

  Fly   222 LQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGT 286
            ::.::|::|.|.|||||:||:||::|:...::..|.||..:||||:|||:|:||::.||.|..|.
Mouse   221 IKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQ 285

  Fly   287 TVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKL 351
            |:||.||:..:.|..|:|...|:|.|||.| |...|.....||:|:||.||||..:||||  |||
Mouse   286 TIGYQIRLESRVSPKTLLTFCTNGVLLRTL-MAGDSTLSTVTHVIVDEVHERDRFSDFLL--TKL 347

  Fly   352 E--LQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKF 414
            .  |||:|.|:|:|.||.:|:.....|||...|:.::||.|||....|||||..|||.:..|.|:
Mouse   348 RDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKY 412

  Fly   415 LGKPTGKETPSELLAAYY-----------------------------GGNTI------------- 437
            ..:...:|.....|..:|                             ||:.:
Mouse   413 KKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLE 477

  Fly   438 ---------------VHPDIDN------------------------------------------- 444
                           :|.|:|.
Mouse   478 PWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFTSQVEQLI 542

  Fly   445 ----------------------------------------------------------------- 444

Mouse   543 SMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDESSLVQTNGNDLSAEDRELL 607

  Fly   445 --------------DLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPR-----EQIT 490
                          |||:.||..:....||||::::||||.::..|..|:.....|     .:..
Mouse   608 KAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQ 672

  Fly   491 IILLHSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDAS 554
            :.:|||.:..|:|:||.:..| ||| ||||||||.:||||:.|:::|||:|..|.|::|:....:
Mouse   673 VFMLHSNMQTSDQKKVLKNPPAGVR-KIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVT 736

  Fly   555 QLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAP- 618
            .|.:.|||:|.|.||.|||||...|.|:||:...|...|..:..||::|..|.|:||.|||.||
Mouse   737 MLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPV 801

  Fly   619 DKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYL 683
            :..|.:||..|.:.||...|..:...||.:..:|..:::|.||:.:|:||:...:||.::.::.|
Mouse   802 NCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVL 866

  Fly   684 RCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIG 748
            :|||.::.||...:.||||||..:..:|....:.|..|.....||.:|:::.::.:.  |.:..|
Mouse   867 KCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQ--KARSDG 929

  Fly   749 ---DFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEA----SARLASSFNNDTNMIRLALTAG 806
               .|||:||:.:..||:.:...:.|...: |...|..|    ..|..::.:.:..:::.||.||
Mouse   930 WERAFCEKNFLSQATMEIIIGMRTQLLGQL-RASGFVRARGGGDIRDVNTNSENWAVVKAALVAG 993

  Fly   807 LYPKLAYMDRENKNQLVAEG--DPLVQVSRSSCLRGKKKQK------------DLASEWILFVEK 857
            :||.|.::||||   ::..|  :..|:...:|.|...:.:|            .|.::|:::.|.
Mouse   994 MYPNLVHVDREN---VILTGPKEKKVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDEM 1055

  Fly   858 TRTADQISSLEHTTLVSGLMV-ALAGGKRFITEA----------------HGSEM---------L 896
            || |.:|:::...:.|:.:.| ...|..|..:.|                ..|||         .
Mouse  1056 TR-AHRIANIRCCSAVTPVTVLVFCGPARLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAA 1119

  Fly   897 LCLDSWIRLKCPAEFGLQLHKVR 919
            |.||.|:..|...|....|.::|
Mouse  1120 LKLDEWLNFKLEPEAASLLLQLR 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	19/61 (31%)
		DEXDc	214..395	CDD:214692	83/182 (46%)
		DEXDc	226..368	CDD:238005	71/143 (50%)
		HELICc	479..575	CDD:197757	44/101 (44%)
		HA2	648..733	CDD:214852	27/84 (32%)
		OB_NTP_bind	783..884	CDD:285018	28/119 (24%)
Ythdc2	NP_001156485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		7/19 (37%)
		R3H_DEXH_helicase	61..119	CDD:100077	18/57 (32%)
		DEXDc	225..364	CDD:238005	69/141 (49%)
		DEAH box	331..334		2/2 (100%)
		ANK	502..587	CDD:238125	0/84 (0%)
		ANK repeat	520..552	CDD:293786	0/31 (0%)
		ANK 1	521..553		0/31 (0%)
		Ank_4	524..574	CDD:290365	0/49 (0%)
		ANK 2	554..586		0/31 (0%)
		ANK repeat	554..582	CDD:293786	0/27 (0%)
		Helicase_C	625..757	CDD:278689	55/132 (42%)
		HA2	831..916	CDD:214852	27/84 (32%)
		OB_NTP_bind	954..1081	CDD:285018	30/131 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1179..1303
		YTH	1304..1434	CDD:282058
		N6-methyladenosine binding. /evidence=ECO:0000250\|UniProtKB:Q9Y5A9	1309..1311
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836881
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4903
OMA	1	1.010	-	-		QHG48010
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106429
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3857
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.610