Protein Alignment CG8915 and DHX30

DIOPT Version :10

• Sequence 1: NP_573208.1
• Gene: CG8915 / 32715
• FlyBaseID: FBgn0030833
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_047303683.1
• Gene: DHX30 / 22907
• HGNCID: 16716
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 906
• Identity: 263/906 - (29%)
• Similarity: 443/906 - (48%)
• Gaps: 131/906 - (14%)

  Fly    43 GKQKTRPGKNAKADAGDKLKS------EDEKM---------LRQLVDDFLQSCEPEKQLPGLTKA 92
            |::|......|.|.|..||||      .:|.:         ||:|.:...:.|..:...|.|.|
Human   365 GRRKAEAENKAAALACKKLKSLGLVDRNNEPLTHAMYNLASLRELGETQRRPCTIQVPEPILRK- 428

  Fly    93 QRSHVHRLAQHRGLKTVSKGPEENRVLFISRPQSDGQQQYILCNTKLDICPPLLDVLGQMAGNVE 157
                :.....|..:::....||       .|.|||            ||.|     ||:.:|.:.
Human   429 ----IETFLNHYPVESSWIAPE-------LRLQSD------------DILP-----LGKDSGPLS 465

  Fly   158 RRLMNSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVL 222
            ..:   .|.......:.:::||..:...:.:|..|         :..|...||:...|::|||.:
Human   466 DPI---TGKPYVPLLEAEEVRLSQSLLELWRRRGP---------VWQEAPQLPVDPHRDTILNAI 518

  Fly   223 QRDQVLIIKGATGSGKSTQLPQYILE-WAAEHR-APVRIVVSQPRRIAAISVSERISKERGEAPG 285
            ::..|::|.|.||.||:|::||.:|| :..|.| |...::::|||||:|:||::|:|.|.|.:..
Human   519 EQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLR 583

  Fly   286 TTVGYNIRM-NRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLAT 349
            ..||:.:|: ::..|....|:..|.|.|||.|..:..  .:..:|:|:||.||||::|||||:..
Human   584 RNVGFQVRLESKPPSRGGALLFCTVGILLRKLQSNPS--LEGVSHVIVDEVHERDVNTDFLLILL 646

  Fly   350 KLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKF 414
            |...:.||.|||||||||.|.|..|.||||..|:.|.|..:.|..::|||||:|.|     ..::
Human   647 KGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAKLG-----KHQY 706

  Fly   415 LGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLAR 479
            |.:....|:..|..             :|.||:..|:..:..:|:.|.::.:|||:.::..:..|
Human   707 LHRHRHHESEDECA-------------LDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQR 758

  Fly   480 LESSLPREQITIILL--HSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGL 541
            |:.:|...:...::|  ||.:...:|:.:|:..| ||| ||:|:|||.:|||||.|:::|:|:||
Human   759 LQEALGMHESKYLILPVHSNIPMMDQKAIFQQPPVGVR-KIVLATNIAETSITINDIVHVVDSGL 822

  Fly   542 AKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTL 606
            .|.:.||.....|.|...|:|:|:..||.|||||...|..|.|:...|:.:|..:.:|||:|..|
Human   823 HKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPL 887

  Fly   607 DEICLLTKLAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGV 671
            :.:.|..|:..|:|....||:.|:|:|...||.::...|:.:||||:|:.:|.||..:|.:....
Human   888 ENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDP 952

  Fly   672 QIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRV--LFAGDGMSDSLAVIK 734
            ::.|.:|.:...|||..::::.:. ..||||..:::    :..::.:|  |.:.|..||.||.::
Human   953 RLAKAIVLAAIFRCLHPLLVVVSC-LTRDPFSSSLQ----NRAEVDKVKALLSHDSGSDHLAFVR 1012

  Fly   735 L---YEEFTNLK-RKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEAS-ARLASS--- 791
            .   :||....: |....::.|.|.:...::...........:.:|..|...:.| ..|||:
Human  1013 AVAGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCN 1077

  Fly   792 -FNNDTNMIRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLR-GKKKQKDLA----SE 850
             ::.:..:::..|.|||||.                  |:||.:....| ||.|...:.    |.
Human  1078 EYSEEEELVKGVLMAGLYPN------------------LIQVRQGKVTRQGKFKPNSVTYRTKSG 1124

  Fly   851 WILFVEKT--RTADQISSLEHTTLVSGLMVALAGGKRFI---TEAHGSEMLLCLDSWIRLK 906
            .||..:.|  |.|.::.|    ..::..|...:.|..|:   ::.|...:||..|..:.::
Human  1125 NILLHKSTINREATRLRS----RWLTYFMAVKSNGSVFVRDSSQVHPLAVLLLTDGDVHIR 1181

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_573208.1	R3H	67..123	CDD:460206	10/64 (16%)
		HrpA	208..>702	CDD:441249	180/499 (36%)
		OB_NTP_bind	799..884	CDD:400182	21/91 (23%)
DHX30	XP_047303683.1	HrpA	497..>1029	CDD:441249	194/566 (34%)
		OB_NTP_bind	1086..1173	CDD:400182	25/108 (23%)