DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx29

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_766182.2	Gene:	Dhx29 / 218629	MGIID:	2145374	Length:	1365	Species:	Mus musculus

Alignment Length:	1131	Identity:	328/1131 - (29%)
Similarity:	512/1131 - (45%)	Gaps:	254/1131 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EAVKRGRRQGRKKAQPMPEQAVVL----VVNGRVTGGPKGTGKQKTRPG-------------KNA 53
            |..|:|:::.::|.:....:...|    :.|..:....:...|:|..|.             |:|
Mouse   282 EKNKQGQKEAQEKIRKFQREMETLEDHPIFNPAIKISHQQNEKKKPAPATEAESALNLNLFEKSA 346

  Fly    54 KADAGDKLKSEDE---------------KMLRQLVDDFLQSCEPEKQLPGLTKAQRSHVHRLAQH 103
            .|...:|.|.::.               |..:|.:.|:::     |.||   |:......::|..
Mouse   347 AATEEEKGKKKEPHDVRNFDYTARSWTGKSPKQFLIDWVR-----KNLP---KSPNPSFEKVAVG 403

  Fly   104 RGLK---TVSKGPEENRVLFISRPQSDGQQ-QYILCNTKL----------DICPPLL-DV----- 148
            |..|   .|.:..::..|:..:....||.| |::.....|          .:.||.. ||
Mouse   404 RYWKCRVRVVRSEDDVLVVCPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPPTYRDVWLEWS 468

  Fly   149 --------LGQMAGNVER-----RLMNSVGDLKCNKQQYKDIRLPSNFG-----------LVG-- 187
                    |.:|..|..|     :|:|.   ||..:||.:..|..|..|           ||.
Mouse   469 DEEKKREELNKMETNKPRDLFIAKLLNK---LKQQQQQQQQQRPESEKGGSEDPEESWENLVSDE 530

  Fly   188 ----------------------QRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLII 230
                                  :||...|:..|   :..||:.||::|.|:||:..|:|.:|:::
Mouse   531 DLAALSLEPTSAEDLAPVRSLFRRLQSTPKYQR---LLKERQQLPVFKHRDSIVETLKRHRVVVV 592

  Fly   231 KGATGSGKSTQLPQYILEWAAEHRAPVR---IVVSQPRRIAAISVSERISKERG--EAPG---TT 287
            .|.||||||||:|.::||.........|   ||.:|||||:|:|::.|:.:|.|  ..||   :.
Mouse   593 AGETGSGKSTQVPHFLLEDLLLDECGARKCNIVCTQPRRISAVSLATRVCEELGCESGPGGRNSL 657

  Fly   288 VGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLE 352
            .||.|||..:.|.:|.|:..|:|.|||.|..|  ....:.:|:|:||.|||.:.:||||:..|..
Mouse   658 CGYQIRMESRASESTRLLYCTTGVLLRKLQED--GLLADVSHVIVDEVHERSVQSDFLLVILKEI 720

  Fly   353 LQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPR----MEK 413
            |||...|.|:|||||:|.:..|.||....::.:.|||:.|.::|||||:.:||::..:    .:|
Mouse   721 LQKRSDLHLILMSATVDSDKFSTYFTHCPILRISGRSYPVEVFHLEDIVEETGFVLEKDSEYCQK 785

  Fly   414 FL-----------GKPTGKETPSELLAAYYGGNTIVHP-------------------DIDNDLIV 448
            ||           .|..|.:...|.:....|.:..::|                   .|:.|||:
Mouse   786 FLEEEEEITINVTSKAGGVKKYQEYIPVQSGASPELNPFYQKYSSRTQHAILYMNPHKINLDLIL 850

  Fly   449 SLLELLLR----QGDAGAVIVYLPGYSDMTSLLARLESS--LPREQITIILLHSQVDNSEQRKVF 507
            .||..|.:    :...|||:::|||.:.:..|...|.|.  ...|:..:|.|||.:...:|...|
Mouse   851 ELLVYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSSDRRFYSERYQVIALHSVLSTQDQAAAF 915

  Fly   508 R-TYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAG 571
            . ..|||| ||:|:|||.:|.|||||:::|||||..|...|..:...|.|..|::|:|.|.||.|
Mouse   916 MFPPPGVR-KIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQG 979

  Fly   572 RAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICL-LTK--LAAPDKKIENFLALALDTP 633
            |||||..|.|:|||..:|......|::|||:|..|:|:|| :.|  |.:|    |:||:.|||.|
Mouse   980 RAGRVRDGFCFRLYTRERFEGFLDYSVPEILRVPLEELCLHIMKCDLGSP----EDFLSKALDPP 1040

  Fly   634 PKDAVMQSCSRLKLLGVLDERD-EVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHS 697
            ....:..:.:.|:.:|..:..: ::||||..:|.||:.|:|||.|::.....||:.:..:||..:
Mouse  1041 QLQVISNAMNLLRKIGACEPNEPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAVMT 1105

  Fly   698 VRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAV-----IKLYEEFTNLK--------RKDIGD 749
            .:.||:..|  |:|....:::         .||||     :.:|..:...|        |.:| .
Mouse  1106 EKSPFITPI--GRKDEADLAK---------SSLAVADSDHLTIYNAYLGWKKAQQEGGFRSEI-S 1158

  Fly   750 FCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLAS------------SFNNDTNMIRLA 802
            :|:|||:.|.::       .||.|....:.:..:|:...:|            || .|..:::..
Mouse  1159 YCQRNFLNRTSL-------LTLEDVKQELMKLVKAAGFSSSPSWEGRKGPQTLSF-QDIALLKAV 1215

  Fly   803 LTAGLY---------------PKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLAS-EW 851
            |.||||               .|||.|..      .|:|.  .||..||.      .:||.: .|
Mouse  1216 LAAGLYDSVGKIMCTKSVDVTEKLACMVE------TAQGK--AQVHPSSV------NRDLQTYGW 1266

  Fly   852 ILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAEFGLQLH 916
            :|:.||.|.....  |..|||::...|.|.||.   .|....|.||.:|.||..:.|.:..:...
Mouse  1267 LLYQEKVRYTRVY--LRETTLITPFPVLLFGGD---IEVQHRERLLSVDGWIYFQAPVKIAVIFK 1326

  Fly   917 KVRMLTDREFAKLVATRKLSLMSDFI 942
            ::|:|.|....|.:...|:||.:|.|
Mouse  1327 QLRVLIDSVLRKKLENPKMSLENDKI 1352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	12/76 (16%)
		DEXDc	214..395	CDD:214692	78/188 (41%)
		DEXDc	226..368	CDD:238005	64/149 (43%)
		HELICc	479..575	CDD:197757	43/98 (44%)
		HA2	648..733	CDD:214852	26/90 (29%)
		OB_NTP_bind	783..884	CDD:285018	34/128 (27%)
Dhx29	NP_766182.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..524		5/23 (22%)
		DEXDc	577..763	CDD:214692	78/187 (42%)
		DEXDc	588..735	CDD:238005	63/148 (43%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03068	701..704		2/2 (100%)
		Helicase_C	863..984	CDD:278689	51/121 (42%)
		HA2	1055..1136	CDD:214852	26/91 (29%)
		OB_NTP_bind	1178..1298	CDD:285018	35/139 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820