DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx8

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_659080.2	Gene:	Dhx8 / 217207	MGIID:	1306823	Length:	1244	Species:	Mus musculus

Alignment Length:	845	Identity:	240/845 - (28%)
Similarity:	390/845 - (46%)	Gaps:	127/845 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EDEKMLRQLVDDFLQSCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGPE-------------- 114
            |||.:..:||::     ||    |.|    |.|..:......:|.| |.|:
Mouse   457 EDEDLEIELVEE-----EP----PFL----RGHTKQSMDMSPIKIV-KNPDGSLSQAAMMQSALA 507

  Fly   115 -ENRVLFISRPQSDGQQQYILCNTKLDICPPLLDVLG-QMAGNVERRLMNSVGDLKCNKQQYKDI 177
             |.|.|  .:.|.:.:...|..........||.|..| |:|.|     |..:|.:..:..::|..
Mouse   508 KERREL--KQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAAN-----MRGIGMMPNDIPEWKKH 565

  Fly   178 RLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQL 242
            ....|....|::        ...:|..:|.||||||.:|.::..:..:|:||:.|.|||||:||:
Mouse   566 AFGGNKASYGKK--------TQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQI 622

  Fly   243 PQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLT 307
            .||:.|  |.:.:..:|..:||||:||:||::|:|:|.|...|..|||.||.....|..||:...
Mouse   623 TQYLAE--AGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYM 685

  Fly   308 TSGCLLRALAMDKKSFFKNTTHLII--DEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDL 370
            |.|.|||...:|...    |.:.||  ||||||.:.||.|....|..:||...::|::.|||:|.
Mouse   686 TDGMLLRECLIDPDL----TQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDA 746

  Fly   371 EALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGN 435
            ...|.||....:..:.||::.|.|.:.                       ||..::.|.|
Mouse   747 VKFSQYFYEAPIFTIPGRTYPVEILYT-----------------------KEPETDYLDA----- 783

  Fly   436 TIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTS----LLARLESSLPR-EQITIILLH 495
                      .:::::::.|.: ..|.::|:|.|..::.:    |..|::|..|. .::.|:.::
Mouse   784 ----------SLITVMQIHLTE-PPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVY 837

  Fly   496 SQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTW 560
            |.:.:..|.::|...|....|::::|||.:||:||..:.||:|.|..|.|.|:|.....||.:|.
Mouse   838 SALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTP 902

  Fly   561 ISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYT--IPEIMRRTLDEICLLTKLAAPDKKIE 623
            ||||.||||||||||...|.||||| .:|..|..:.|  :|||.|..|....|..|...    |.
Mouse   903 ISQAQAKQRAGRAGRTGPGKCYRLY-TERAYRDEMLTTNVPEIQRTNLASTVLSLKAMG----IN 962

  Fly   624 NFLAL-ALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLD 687
            :.|:. .:|.||.:.::.:..:|..||.||:...:|.||..:||.||...:.|.|:.|::|.|.:
Mouse   963 DLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSE 1027

  Fly   688 SMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCE 752
            .|:.|.:..||::.|....::...:.|:.:: ....:|  |.|.::.:|..:.|  .|....:|.
Mouse  1028 EMLTIVSMLSVQNVFYRPKDKQALADQKKAK-FHQTEG--DHLTLLAVYNSWKN--NKFSNPWCY 1087

  Fly   753 RNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMD-R 816
            .|||...::.    .|..:|..:..|....:..   ..|....|..::.|:.:|.:...|..| :
Mouse  1088 ENFIQARSLR----RAQDIRKQMLGIMDRHKLD---VVSCGKSTVRVQKAICSGFFRNAAKKDPQ 1145

  Fly   817 ENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALA 881
            |....|:.:  .:|.:..||.|..::      .||:::.|...|..:... |.||:....:|..|
Mouse  1146 EGYRTLIDQ--QVVYIHPSSALFNRQ------PEWVVYHELVLTTKEYMR-EVTTIDPRWLVEFA 1201

Fly 882 881
Mouse 1202 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	18/73 (25%)
		DEXDc	214..395	CDD:214692	70/182 (38%)
		DEXDc	226..368	CDD:238005	61/143 (43%)
		HELICc	479..575	CDD:197757	39/96 (41%)
		HA2	648..733	CDD:214852	25/84 (30%)
		OB_NTP_bind	783..884	CDD:285018	21/100 (21%)
Dhx8	NP_659080.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..289
		S1_DHX8_helicase	289..367	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..396
		DEXDc	585..770	CDD:214692	77/190 (41%)
		DEXDc	606..744	CDD:238005	61/143 (43%)
		DEAH box	709..712		2/2 (100%)
		HELICc	769..926	CDD:238034	55/195 (28%)
		HA2	988..1070	CDD:214852	25/84 (30%)
		OB_NTP_bind	1104..1203	CDD:285018	22/110 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810