DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx33

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_848144.3	Gene:	Dhx33 / 216877	MGIID:	2445102	Length:	698	Species:	Mus musculus

Alignment Length:	722	Identity:	211/722 - (29%)
Similarity:	340/722 - (47%)	Gaps:	111/722 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 GQRLIPP---PQSNRNRN-IQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYIL 247
            |:|..||   |.::..|. ::.:||||||::.|..:|..|:.....::.|.|||||:||:|||:.
Mouse    39 GRRQTPPLAQPSASPYREALELQRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLY 103

  Fly   248 EWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCL 312
            |.....:.  .|.|:||||:||||::.|:|.|:....|..|||.:|.....|.:|.:...|.|.|
Mouse   104 EGGISRQG--IIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGML 166

  Fly   313 LRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKL------ELQKNPHLRLVLMSATMDLE 371
            ||....|  |..:..:.:|:||||||.:.||.|....|.      ||.|.| |::::||||||::
Mouse   167 LREAISD--SLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLP-LKVIVMSATMDVD 228

  Fly   372 ALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNT 436
            ..|.||....|:.:|||...:.|::.:.  .:..|:|                    ||
Mouse   229 LFSQYFNRAPVLYLEGRQHPIQIFYTKQ--PQQDYLH--------------------AA------ 265

  Fly   437 IVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSL------LAR-LESSLPREQITIILL 494
                      :||:.::......:..::|:|.|..::.::      :|| |....|  .:.::.|
Mouse   266 ----------LVSVFQIHQEAPASQDILVFLTGQEEIEAMSKTCRDIARHLPDGCP--SMLVLPL 318

  Fly   495 HSQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLT 559
            ::.:..|:|.:||:..|....|:|:||||.:|||||..:.||:|||:.|.|.|:.......|.:.
Mouse   319 YASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQ 383

  Fly   560 WISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIEN 624
            .:|:..|.||.|||||...|.|||||..|...:....|:|||.|..|..:.|  :|.|  .|:.|
Mouse   384 RVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFEKMTVPEIQRCNLASVIL--QLLA--MKVPN 444

  Fly   625 FLAL-ALDTPPKDAVMQSCSRLKLLGVLDERDE---VTPLGHIVAELPLGVQIGKCLVYSIYLRC 685
            .|.. .:..|..|.:..:.::|.|||.|:.:|:   :||:|..:|..||..:..|.::.|....|
Mouse   445 VLTFDFMSKPSPDHIEAAIAQLDLLGALEHKDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHC 509

  Fly   686 LDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIG-- 748
            .:.::.|.:..|| |..:.|....:...|.:.:...:.:|  |.:.::.:|..|     |:||
Mouse   510 TEEILTIVSLLSV-DSVLYNPPARRDEVQSVRKKFISSEG--DHITLLNIYRTF-----KNIGGN 566

  Fly   749 -DFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLA 812
             |:|:.||:....|.:.....:.||:...::      |..:.|| ..|...:|..:...|:...|
Mouse   567 KDWCKENFVNSKNMLLVAEVRAQLREICLKM------SMPIMSS-RGDMESVRRCMAHSLFMNTA 624

  Fly   813 YMDRE------NKNQLVA--------EGDPLVQVSRSSCLRGKKKQKDLA---SEWI------LF 854
            .:..:      :.:|.||        ...|...|..|.....|...:||.   :||:      .|
Mouse   625 ELQTDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAPDYF 689

  Fly   855 VEKTRTA 861
            ..|.|||
Mouse   690 RRKLRTA 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	71/186 (38%)
		DEXDc	226..368	CDD:238005	58/147 (39%)
		HELICc	479..575	CDD:197757	36/96 (38%)
		HA2	648..733	CDD:214852	21/87 (24%)
		OB_NTP_bind	783..884	CDD:285018	23/102 (23%)
Dhx33	NP_848144.3	Required for nucleolar location. /evidence=ECO:0000250\|UniProtKB:Q9H6R0	1..71		12/31 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..50		4/10 (40%)
		DEXDc	49..252	CDD:214692	79/207 (38%)
		DEXDc	83..225	CDD:238005	58/146 (40%)
		DEAH box	185..188		2/2 (100%)
		Helicase_C	282..399	CDD:278689	40/118 (34%)
		IBP39	409..>500	CDD:288304	28/94 (30%)
		HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000250\|UniProtKB:Q9H6R0	462..553		23/93 (25%)
		HA2	469..554	CDD:214852	21/87 (24%)
		Critical for rDNA-binding	536..550		2/15 (13%)
		OB_NTP_bind	588..688	CDD:285018	20/106 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810