DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx37

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_017176254.1	Gene:	Dhx37 / 208144	MGIID:	3028576	Length:	1161	Species:	Mus musculus

Alignment Length:	1096	Identity:	248/1096 - (22%)
Similarity:	411/1096 - (37%)	Gaps:	344/1096 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KRGRRQGRKKAQPMP----------------------EQAVVLVVNGRVTGGPKGTGKQKTR--- 48
            :|...:||.:|.|.|                      :::.|||:.|:        .|:||:
Mouse     6 RRYNVKGRLQADPRPAKGPEAPPVRLELEGKDVLKGVDESNVLVLPGK--------RKKKTKAPP 62

  Fly    49 PGKNAKADAGDKLKSEDEKMLRQLVDDFLQSCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGP 113
            |.|..:    ..|..::.|:|:::::...:..:..:.|..|::.|.|.    |:.....|.:|..
Mouse    63 PSKKER----KPLTKKERKVLQKVLEQKEKKSQRAELLQKLSEVQVSE----AEMSLFYTTAKLG 119

  Fly   114 EENRVLFI-----SRPQSDGQQQYILCNTKLDICPPLLDVLGQMAGNVERRLMNSVGDLKCNKQQ 173
            ..:|:..|     .:|.:.||::                 :..::|...:|..:|..:......:
Mouse   120 TGDRMYHIKERKSGQPAARGQEK-----------------VSSLSGAHRKRHRSSSTEEDSESSE 167

  Fly   174 YKDIR--------------------LPSNFGLVGQRLIPPPQS---------------------- 196
            ..:..                    .||..........|||..
Mouse   168 DSEPEEATADQPRTSTGTEPVHPPPAPSGINSPAPTPQPPPSGISAPPKTPASAPPPPVAKPAVF 232

  Fly   197 ---NRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILE--WAAEHRAP 256
               ||...:|.||..|||..:.::|:..:....::|:.|.|||||:||:||::.|  :::|...
Mouse   233 IPVNRTPEMQEERLKLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGYSSEDSI- 296

  Fly   257 VRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKK 321
              |.|::|||:||:::|:|::||. ......|.|.||.....:..|.:...|.|.||:.:  .|.
Mouse   297 --IGVTEPRRVAAVAMSQRVAKEM-NLSHRVVSYQIRYEGNVTEETRIKFMTDGVLLKEI--QKD 356

  Fly   322 SFFKNTTHLIIDEAHERDLDTDFL--LLATKLELQKNPH--LRLVLMSATMDLEALSN----YFG 378
            ........:||||||||.:.||.|  ||:..:.|:...|  |:|::||||:.:|..:.    :..
Mouse   357 FLLLKYKVVIIDEAHERSVYTDILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTT 421

  Fly   379 GGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTI-----V 438
            ...|:.||.|.|.|:::.                       .|.||.:    .|.|...     :
Mouse   422 PPPVIKVESRQFPVTVHF-----------------------NKRTPLD----DYSGECFRKVCKI 459

  Fly   439 HPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLP------------------ 485
            |                |...||.::|:|.|.:::.:|..||..:.|
Mouse   460 H----------------RMLPAGGILVFLTGQAEVHALCRRLRKAFPFRCSQPQEKEEDSAEGMR 508

  Fly   486 ------------------------------------RE--------------------------- 487
                                                ||
Mouse   509 RFKKSRTRARKAQAMALPQINLDNYSVLPAGEGDEDREAEMDDEEEALGSDLDLDLGDSEANEGE 573

  Fly   488 ------QITIILLHSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMK 545
                  .:.::.|:|.:...:|.:||:..| |.|| .:::||:.:||:|||.:.||:|.|..|.:
Mouse   574 QPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRL-CVVATNVAETSLTIPGIKYVVDCGKVKKR 637

  Fly   546 TYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEIC 610
            .||.....|...:||:|||.|.||||||||...|:|||||.:........:..|||.||.::::.
Mouse   638 YYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLI 702

  Fly   611 LLTKLAAPDKKI-----------------ENFLAL-ALDTPPKDAVMQSCSRLKLLGVLDERDEV 657
            |..|..:.:|.|                 |..:|| ||..|||.      .|:|.|.:......:
Mouse   703 LQMKALSIEKVINFPFPTPPSVEALVAAEELLVALGALQAPPKQ------ERMKKLQMSQLSCPI 761

  Fly   658 TPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRV--- 719
            |.||..::..|:..:..|.|..|....||...|.|.|..:||:.|. .::|...|.::::.:
Mouse   762 TALGRTMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRELFE-ELDRPAASEKELAELKGR 825

  Fly   720 ---------LFAGDGMSDSLAVIKLYEEFTNLKRKDIG---------DFCERNFICRNAMEMFVS 766
                     .:||.|.|     :||.:....|..  :|         .||:.|.:...||.....
Mouse   826 RARVAQMKRTWAGQGPS-----LKLGDLMVLLGA--VGACEYAGCSPQFCQANGLRYKAMLEIRR 883

  Fly   767 AASTLRDTVYRIFRFSEA----SARLASSFNNDTNMIRLALTAGLYPKLA-------YMDRENKN 820
            ....|...|..:  ..||    ..::.....:....:|..:.|||...||       .:|.:.||
Mouse   884 LRGQLTTAVNAV--CPEAGLFLDPKMQPPTESQVTYLRQIMAAGLGDHLARRVQSEDLLDPKWKN 946

  Fly   821 QLVAEGDPL----VQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQ----ISSLE 868
               |...||    |.:..||.|     .|:| .|::::.|...|...    :|::|
Mouse   947 ---AYKTPLLDDPVFIHPSSVL-----FKEL-PEFVVYQEIVETTKMYMKGVSTVE 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	11/63 (17%)
		DEXDc	214..395	CDD:214692	63/190 (33%)
		DEXDc	226..368	CDD:238005	54/147 (37%)
		HELICc	479..575	CDD:197757	41/183 (22%)
		HA2	648..733	CDD:214852	22/96 (23%)
		OB_NTP_bind	783..884	CDD:285018	25/105 (24%)
Dhx37	XP_017176254.1	HrpA	236..1009	CDD:224557	210/833 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810