DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and ddx-15

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_741147.1	Gene:	ddx-15 / 175771	WormBaseID:	WBGene00018967	Length:	739	Species:	Caenorhabditis elegans

Alignment Length:	722	Identity:	210/722 - (29%)
Similarity:	351/722 - (48%)	Gaps:	103/722 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 RRLMNSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVL 222
            :|.:.:||::|.....|.:                .|.|||...|..:|..||:::.:|..:.:|
Worm    41 KRQIGAVGNMKIQINPYNN----------------QPFSNRYWAIWEKRSQLPVWEYKEKFMELL 89

  Fly   223 QRDQVLIIKGATGSGKSTQLPQYILEWAAEHR-----APVRIVV-SQPRRIAAISVSERISKERG 281
            :.:|.:.:.|.|||||:||:||:.:|:..:.:     ...|:|. :||||:||:||:.|:::|..
Worm    90 RNNQCITLVGETGSGKTTQIPQWAVEFMKQQQQGQPPGQARLVACTQPRRVAAMSVATRVAEEMD 154

  Fly   282 EAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLL 346
            ...|..|||:||.....|..|||...|.|.|||. ||:.....|... ||:||||||.|.||.|:
Worm   155 VVLGQEVGYSIRFEDCISERTVLKYCTDGMLLRE-AMNSPLLDKYKV-LILDEAHERTLATDILM 217

  Fly   347 LATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRM 411
            ...|..::....:::|:||||:|......||....::.|.||:|.|.|           :..|..
Worm   218 GLIKEIVRNRADIKVVIMSATLDAGKFQRYFEDCPLLSVPGRTFPVEI-----------FFTPNA 271

  Fly   412 EKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSL 476
            ||                           |.....|.:::::.:.:...|.::::|.|..::...
Worm   272 EK---------------------------DYLEAAIRTVIQIHMVEEVEGDILLFLTGQEEIEEA 309

  Fly   477 LARLESSL-----PREQITIILLHSQVDNSEQRKVFRTYP------GVRLKIILSTNIGQTSITI 530
            ..|::..:     ....::.|.|:|.:..:.|:::|...|      .:..|.::||||.:||:||
Worm   310 CKRIDREIQALGADAGALSCIPLYSTLPPAAQQRIFEPAPPNRPNGAISRKCVISTNIAETSLTI 374

  Fly   531 PDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRM-ARMN 594
            ..:::|||.|.:|.|.|:..|....|.:..||:|.|.||||||||...|.|:|||..... :.|.
Worm   375 DGVVFVIDPGFSKQKVYNPRIRVESLLVCPISKASAMQRAGRAGRTKPGKCFRLYTETAYGSEMQ 439

  Fly   595 LYTIPEIMRRTLDEICL-LTKLAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVT 658
            ..|.|||:|..|..:.| |.||...|....:|    :|.|..:.:|::...|..|..:::..|:|
Worm   440 DQTYPEILRSNLGSVVLQLKKLGTEDLVHFDF----MDPPAPETLMRALELLNYLQAINDDGELT 500

  Fly   659 PLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAG 723
            .||.::||.||..|:.|.|:.|..|.|.:.::.|.|..||...:|...|...::.:..:|  ||.
Worm   501 ELGSLMAEFPLDPQLAKMLITSTELNCSNEILSITAMLSVPQCWVRPNEMRTEADEAKAR--FAH 563

  Fly   724 -DGMSDSLAVIKLYEEFTNLKRKDIGDFCERNFICRNAMEMFVSAASTLRDTVYRIF-RFSEASA 786
             ||  |.|.::.:|..|.  :.::...:|..|||....|:    .|.|:|..:.|:. :::  ..
Worm   564 IDG--DHLTLLNVYHSFK--QNQEDPQWCYDNFINYRTMK----TADTVRTQLSRVMDKYN--LR 618

  Fly   787 RLASSF-NNDTNM-IRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLAS 849
            |:::.| :.|..: ||.||.||.:.::|:::|.. :.:..:.:.||.:..|:.|       |...
Worm   619 RVSTDFKSRDYYLNIRKALVAGFFMQVAHLERSG-HYVTVKDNQLVNLHPSTVL-------DHKP 675

  Fly   850 EWILFVE 856
            ||.|:.|
Worm   676 EWALYNE 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	70/186 (38%)
		DEXDc	226..368	CDD:238005	59/147 (40%)
		HELICc	479..575	CDD:197757	35/106 (33%)
		HA2	648..733	CDD:214852	28/85 (33%)
		OB_NTP_bind	783..884	CDD:285018	20/76 (26%)
ddx-15	NP_741147.1	Motor_domain	41..>106	CDD:277568	21/80 (26%)
		DEXDc	70..266	CDD:214692	74/208 (36%)
		DEXDc	95..239	CDD:238005	58/145 (40%)
		HELICc	327..419	CDD:197757	34/91 (37%)
		HA2	489..572	CDD:214852	28/86 (33%)
		OB_NTP_bind	607..709	CDD:285018	21/86 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910