DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and ddx-35

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_497420.1	Gene:	ddx-35 / 175308	WormBaseID:	WBGene00022056	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	674	Identity:	197/674 - (29%)
Similarity:	317/674 - (47%)	Gaps:	80/674 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 NIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILE--WAAEHRAPVRIVVSQ 263
            |||.:|..|||:|.|..||.:.:|.:.:||.|.||.|||||:||::||  |||:.|   :||::|
Worm    69 NIQQQRIRLPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGR---QIVITQ 130

  Fly   264 PRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTT 328
            |||:|.::::.|:::|:....|..|||.:|.:.....:|.:...|.|.|||.:..|  ......:
Worm   131 PRRVAVVTLATRVAEEKDCILGHDVGYTVRFDDVSDKDTKVKFMTDGLLLREILAD--PLLSKYS 193

  Fly   329 HLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYF-----GGGT-----VM 383
            .::|||||||..:||.||...:..:|....||:::.|||:|.|...::|     |...     ::
Worm   194 IIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDAELFKDFFEMNETGNSDKDTAGII 258

  Fly   384 DVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDIDNDLIV 448
            .||||:..|:::|     :||..                                 ||.....:.
Worm   259 SVEGRTHPVAVHH-----TKTSV---------------------------------PDYCQSAVD 285

  Fly   449 SLLELLLRQGDAGAVIVYLPG---YSDMTSLLARLESSLPR-EQITIILLHSQVDNSEQRKVFRT 509
            :::. :.:..:.|.::|:|.|   ..|:...|..|..:|.. :::.::..:..:...||.|.|.:
Worm   286 TVIN-IHKHENPGDILVFLTGQDEVEDVCEKLRELAGNLKNCDRLWVVPCYGALPAREQMKAFDS 349

  Fly   510 YPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAG 574
            .|....|::::|||.:.|||||.:.||||||..|::...:......|....:|:|.|:|||||||
Worm   350 TPHGTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQHAANGVETLMRVTVSKASAEQRAGRAG 414

  Fly   575 RVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLALALDTPPKDAVM 639
            |:..|.|||||......|....|:|||.|..:....|..| |...:.:..|..|:  .||..|::
Worm   415 RIRPGKCYRLYPESEFERFAEGTVPEIQRCQMASTILQLK-ALGVQNVHRFHYLS--PPPSWAMI 476

  Fly   640 QSCSRLKLLGVLDERDEVT-PLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFV 703
            .....|..||.:||..::| |||..:||.||.....|||:.|....|...|:.|.|...::|.|:
Worm   477 NGLELLYALGAIDETSQLTSPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDVFI 541

  Fly   704 LNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCERNFI-CRNAMEMFVSA 767
            ....:..::  .:.|..||.: ..|.:.::.::.:|....|..  .:|..:|: .|..|.
Worm   542 TPYRQRHQA--DVIRKKFAVE-EGDHMTMLNVFTKFVENGRSK--KWCSDHFVNYRGLMR----- 596

  Fly   768 ASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQV 832
            |..:|..:.|:.:..|.....:....|.:..||..|..|.:.:.|......|...|.|..|....
Worm   597 ADNVRSQLVRLLKRFEIEKVSSRGLINCSENIRQCLVTGFFSQAAQYHYTGKYMTVKESFPFNMY 661

  Fly   833 SRSSCLRGKKKQKDLASEWILFVE 856
            ..||.:..|...|     |::|.|
Worm   662 KGSSIMFKKDYPK-----WVIFTE 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	69/192 (36%)
		DEXDc	226..368	CDD:238005	55/143 (38%)
		HELICc	479..575	CDD:197757	33/96 (34%)
		HA2	648..733	CDD:214852	26/85 (31%)
		OB_NTP_bind	783..884	CDD:285018	18/74 (24%)
ddx-35	NP_497420.1	HrpA	70..702	CDD:224557	196/673 (29%)
		DEXDc	96..233	CDD:238005	55/141 (39%)
		Helicase_C	284..416	CDD:278689	40/132 (30%)
		HA2	484..568	CDD:214852	26/86 (30%)
		OB_NTP_bind	602..704	CDD:285018	19/84 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810