DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8915 and DHX36

DIOPT Version :9

Sequence 1:NP_001285369.1 Gene:CG8915 / 32715 FlyBaseID:FBgn0030833 Length:976 Species:Drosophila melanogaster
Sequence 2:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens


Alignment Length:964 Identity:295/964 - (30%)
Similarity:474/964 - (49%) Gaps:135/964 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 GGPKGTGKQKTRPG-----------------KNAKADAGDK-LKSEDEKMLRQLVDDFLQSCEPE 83
            ||..|.|.:...||                 ||.:|:..:: :...||:...|:| ..|.|.:.:
Human    42 GGGGGRGGRGRHPGHLKGREIGMWYAKKQGQKNKEAERQERAVVHMDERREEQIV-QLLNSVQAK 105

  Fly    84 KQLPGLTKAQRSHVHRLAQHRGLKTVSKGPEEN----RVLFISRPQSDGQQQYILCNTKLDICPP 144
            ..     |...:.:...|           ||::    .|...:.|.|:         .||||   
Human   106 ND-----KESEAQISWFA-----------PEDHGYGTEVSTKNTPCSE---------NKLDI--- 142

  Fly   145 LLDVLGQMAGNVERRLMNSVGDL-KCNKQQYKD----IRLPSN--FGLVGQRLIPPPQSNRNR-- 200
                       .|::|:|....: :...:.|.|    ..|..|  .|.:.|:|:...|..:|.  
Human   143 -----------QEKKLINQEKKMFRIRNRSYIDRDSEYLLQENEPDGTLDQKLLEDLQKKKNDLR 196

  Fly   201 --NIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEH--RAPVRIVV 261
              .:||.|..||.|..::.::|::...||.:|.|.||.||:||:.|:||:...|.  .:..|||.
Human   197 YIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVC 261

  Fly   262 SQPRRIAAISVSERISKERGEA--PGTTVGYNIRMNRQC--SSNTVLMLTTSGCLLRALAMDKKS 322
            :|||||:||||:||::.||.|:  .|.:.||.||:..:.  ...::|..|| |.:|:.|..|  .
Human   262 TQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRLPRKQGSILYCTT-GIILQWLQSD--P 323

  Fly   323 FFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEG 387
            :..:.:|:::||.|||:|.:|.|:...|..|.....|:::|||||::.|..|.|||...::.:.|
Human   324 YLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPG 388

  Fly   388 RSFEVSIYHLEDILSKTGYMHPRMEK-------FLGKPTGKETPSELLAAY-------------- 431
            .:|.|..|.|||::.|..|:..:.|.       |:.....::...|..|.|              
Human   389 FTFPVVEYLLEDVIEKIRYVPEQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPDYVRELRRR 453

  Fly   432 YGGNTI-----VHPD-IDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSL--PREQ 488
            |..:|:     :..| :|.:|||:|:..::.:.:.||::|:|||:.::::|...|.|.:  ..::
Human   454 YSASTVDVIEMMEDDKVDLNLIVALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDK 518

  Fly   489 ITIILLHSQVDNSEQRKVF-RTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTID 552
            ..||.|||.:....|.:|| ||.|||| ||:::|||.:|||||.|::||||.|..|...:|:..:
Human   519 FLIIPLHSLMPTVNQTQVFKRTPPGVR-KIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNN 582

  Fly   553 ASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAA 617
            .|.::..|:|:|:||||.||||||..|:||.||:..|.:.::.|.:|||:|..|:|:||..|:..
Human   583 ISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILR 647

  Fly   618 PDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIY 682
            .. .|..||:..:|.|..:||:.|...|..|..||:::|:||||..:|.||:...|||.:::...
Human   648 LG-GIAYFLSRLMDPPSNEAVLLSIRHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGAL 711

  Fly   683 LRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDI 747
            ..|||.::.|||..|.:||||:.:  ||:......|...|.|..||.|.|:..:|.:...:|:..
Human   712 FCCLDPVLTIAASLSFKDPFVIPL--GKEKIADARRKELAKDTRSDHLTVVNAFEGWEEARRRGF 774

  Fly   748 ---GDFCERNFICRNAMEMFVSAASTLRDTVYRI-FRFSEASARLASSFNNDT-NMIRLALTAGL 807
               .|:|...|:..|.::|..:......:.:... |..|.......|:.|:|. .:|:..:.|||
Human   775 RYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNINSDNEKIIKAVICAGL 839

  Fly   808 YPKLA--YMDRENKNQLV---AEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSL 867
            |||:|  .::...|.::|   .:.|.||.|...|.   ..:|.|....|:::..|.||:.  ..|
Human   840 YPKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSV---NVEQTDFHYNWLIYHLKMRTSS--IYL 899

  Fly   868 EHTTLVSGLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAEFGLQLHKVRML 921
            ...|.||...:...||...|.:.:..| .:.:|.||..:.||...   |.|:.|
Human   900 YDCTEVSPYCLLFFGGDISIQKDNDQE-TIAVDEWIVFQSPARIA---HLVKEL 949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8915NP_001285369.1 R3H 64..123 CDD:100064 11/62 (18%)
DEXDc 214..395 CDD:214692 69/186 (37%)
DEXDc 226..368 CDD:238005 59/147 (40%)
HELICc 479..575 CDD:197757 45/98 (46%)
HA2 648..733 CDD:214852 33/84 (39%)
OB_NTP_bind 783..884 CDD:285018 29/106 (27%)
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 38/197 (19%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104 15/62 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58 6/15 (40%)
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51 4/8 (50%)
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105 11/52 (21%)
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75 3/21 (14%)
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 95/321 (30%)
DEXDc 210..392 CDD:214692 68/184 (37%)
DEXDc 224..369 CDD:238005 59/147 (40%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 21/52 (40%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 84/241 (35%)
Helicase_C 476..606 CDD:278689 55/130 (42%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 22/59 (37%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 5/10 (50%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 28/69 (41%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 22/59 (37%)
HA2 676..760 CDD:214852 33/85 (39%)
OB_NTP_bind 800..917 CDD:285018 32/121 (26%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 18/68 (26%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 2/10 (20%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 7/34 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222681at33208
OrthoFinder 1 1.000 - - FOG0000258
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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