DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and DHX15

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001349.2	Gene:	DHX15 / 1665	HGNCID:	2738	Length:	795	Species:	Homo sapiens

Alignment Length:	786	Identity:	223/786 - (28%)
Similarity:	365/786 - (46%)	Gaps:	142/786 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 GLVGQRLIPP--------PQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKST 240
            |..|...:|.        |.:.|..:|..:|..||:::.::...::|.|.|..::.|.|||||:|
Human   104 GHAGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTT 168

  Fly   241 QLPQYILEWAAEHRAPVR-IVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVL 304
            |:||:.:|:......|.| :..:||||:||:||::|::.|.....|..|||:||.....|:.|:|
Human   169 QIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTIL 233

  Fly   305 MLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMD 369
            ...|.|.|||....|  ...:....:|:||||||.|.||.|:...|..:::...|::::||||:|
Human   234 KYMTDGMLLREAMND--PLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLD 296

  Fly   370 LEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGG 434
            ......||....::.:.||:..|.|::                          ||
Human   297 AGKFQIYFDNCPLLTIPGRTHPVEIFY--------------------------TP---------- 325

  Fly   435 NTIVHPDID--NDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPRE---------Q 488
                .|:.|  ...|.:::::.:.:.:.|.::::|.|..::.....|::    ||         .
Human   326 ----EPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIK----REVDDLGPEVGD 382

  Fly   489 ITIILLHSQVDNSEQRKVFRTYP------GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTY 547
            |.||.|:|.:...:|:::|...|      .:..|:::||||.:||:||..:::|||.|.||.|.|
Human   383 IKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVY 447

  Fly   548 DSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLY-DNDRMARMNLYTIPEIMRRTLDEICL 611
            :..|....|.:|.||:|.|:||||||||...|.|:||| :......|...|.|||:|..|..:.|
Human   448 NPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVL 512

  Fly   612 -LTKLAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGK 675
             |.||...|....:|    :|.|..:.:|::...|..|..|::..::|.||.::||.||..|:.|
Human   513 QLKKLGIDDLVHFDF----MDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAK 573

  Fly   676 CLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAG-DGMSDSLAVIKLYEEF 739
            .::.|....|.:.::.|.|..||...||...| .||:..: :::.||. ||  |.|.::.:|..|
Human   574 MVIASCDYNCSNEVLSITAMLSVPQCFVRPTE-AKKAADE-AKMRFAHIDG--DHLTLLNVYHAF 634

  Fly   740 TNLKRKDIGDFCERNFI-CRNAMEMFVSAASTLRDTVYRIF-RFSEASARLASSFNNDTNM--IR 800
            .  :..:...:|..||| .|:.|     :|..:|..:.||. ||:  ..|.::.|.:....  ||
Human   635 K--QNHESVQWCYDNFINYRSLM-----SADNVRQQLSRIMDRFN--LPRRSTDFTSRDYYINIR 690

  Fly   801 LALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQIS 865
            .||..|.:.::|:::|.. :.|..:.:.:||:..|:.|       |...||:|:.|...|.
Human   691 KALVTGYFMQVAHLERTG-HYLTVKDNQVVQLHPSTVL-------DHKPEWVLYNEFVLTT---- 743

  Fly   866 SLEHTTLVSGLMVALAGGKRFITEAHGSEMLLCLD---SWIRLKCPAEFGL----QLHKVRMLTD 923
                              |.:|.        .|.|   .|:....|..:.:    |....|.| |
Human   744 ------------------KNYIR--------TCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQL-D 781

  Fly   924 REFAKL 929
            |..|||
Human   782 RIIAKL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	64/181 (35%)
		DEXDc	226..368	CDD:238005	55/142 (39%)
		HELICc	479..575	CDD:197757	41/110 (37%)
		HA2	648..733	CDD:214852	28/85 (33%)
		OB_NTP_bind	783..884	CDD:285018	20/102 (20%)
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108		1/3 (33%)
		HrpA	124..763	CDD:224557	210/739 (28%)
		DEAH box	260..263		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810