Protein Alignment CG8915 and DHX8

DIOPT Version :10

• Sequence 1: NP_573208.1
• Gene: CG8915 / 32715
• FlyBaseID: FBgn0030833
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_004932.1
• Gene: DHX8 / 1659
• HGNCID: 2749
• Length: 1220
• Species: Homo sapiens
• Alignment Length: 845
• Identity: 240/845 - (28%)
• Similarity: 390/845 - (46%)
• Gaps: 127/845 - (15%)

  Fly    64 EDEKMLRQLVDDFLQSCEPEKQLPGLTKAQRSHVHRLAQHRGLKTVSKGPE-------------- 114
            |||.:..:||::     ||    |.|    |.|..:......:|.| |.|:
Human   433 EDEDLEIELVEE-----EP----PFL----RGHTKQSMDMSPIKIV-KNPDGSLSQAAMMQSALA 483

  Fly   115 -ENRVLFISRPQSDGQQQYILCNTKLDICPPLLDVLG-QMAGNVERRLMNSVGDLKCNKQQYKDI 177
             |.|.|  .:.|.:.:...|..........||.|..| |:|.|     |..:|.:..:..::|..
Human   484 KERREL--KQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAAN-----MRGIGMMPNDIPEWKKH 541

  Fly   178 RLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQL 242
            ....|....|::        ...:|..:|.||||||.:|.::..:..:|:||:.|.|||||:||:
Human   542 AFGGNKASYGKK--------TQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQI 598

  Fly   243 PQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLT 307
            .||:.|  |.:.:..:|..:||||:||:||::|:|:|.|...|..|||.||.....|..||:...
Human   599 TQYLAE--AGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYM 661

  Fly   308 TSGCLLRALAMDKKSFFKNTTHLII--DEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDL 370
            |.|.|||...:|...    |.:.||  ||||||.:.||.|....|..:||...::|::.|||:|.
Human   662 TDGMLLRECLIDPDL----TQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDA 722

  Fly   371 EALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGN 435
            ...|.||....:..:.||::.|.|.:.                       ||..::.|.|
Human   723 VKFSQYFYEAPIFTIPGRTYPVEILYT-----------------------KEPETDYLDA----- 759

  Fly   436 TIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTS----LLARLESSLPR-EQITIILLH 495
                      .:::::::.|.: ..|.::|:|.|..::.:    |..|::|..|. .::.|:.::
Human   760 ----------SLITVMQIHLTE-PPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVY 813

  Fly   496 SQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTW 560
            |.:.:..|.::|...|....|::::|||.:||:||..:.||:|.|..|.|.|:|.....||.:|.
Human   814 SALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTP 878

  Fly   561 ISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYT--IPEIMRRTLDEICLLTKLAAPDKKIE 623
            ||||.||||||||||...|.||||| .:|..|..:.|  :|||.|..|....|..|...    |.
Human   879 ISQAQAKQRAGRAGRTGPGKCYRLY-TERAYRDEMLTTNVPEIQRTNLASTVLSLKAMG----IN 938

  Fly   624 NFLAL-ALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLD 687
            :.|:. .:|.||.:.::.:..:|..||.||:...:|.||..:||.||...:.|.|:.|::|.|.:
Human   939 DLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSE 1003

  Fly   688 SMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCE 752
            .|:.|.:..||::.|....::...:.|:.:: ....:|  |.|.::.:|..:.|  .|....:|.
Human  1004 EMLTIVSMLSVQNVFYRPKDKQALADQKKAK-FHQTEG--DHLTLLAVYNSWKN--NKFSNPWCY 1063

  Fly   753 RNFICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMD-R 816
            .|||...::.    .|..:|..:..|....:..   ..|....|..::.|:.:|.:...|..| :
Human  1064 ENFIQARSLR----RAQDIRKQMLGIMDRHKLD---VVSCGKSTVRVQKAICSGFFRNAAKKDPQ 1121

  Fly   817 ENKNQLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALA 881
            |....|:.:  .:|.:..||.|..::      .||:::.|...|..:... |.||:....:|..|
Human  1122 EGYRTLIDQ--QVVYIHPSSALFNRQ------PEWVVYHELVLTTKEYMR-EVTTIDPRWLVEFA 1177

  Fly   882  881
            Human  1178  1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_573208.1	R3H	67..123	CDD:460206	15/70 (21%)
		HrpA	208..>702	CDD:441249	170/503 (34%)
		OB_NTP_bind	799..884	CDD:400182	19/84 (23%)
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..266
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..372
		HrpA	556..>1187	CDD:441249	208/693 (30%)
		DEAH box	685..688		2/2 (100%)