DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and Dhx15

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_031865.2	Gene:	Dhx15 / 13204	MGIID:	1099786	Length:	795	Species:	Mus musculus

Alignment Length:	946	Identity:	246/946 - (26%)
Similarity:	403/946 - (42%)	Gaps:	221/946 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NGRVTGGPKGTGKQKTR------PGKNAKADAGDK---LKSEDEKMLRQLVDDFLQSCEPEKQLP 87
            :|:...|..|..:::.|      ..::.:.|.||:   .:.|.||.||...:..|.|.    .||
Mouse    15 SGKKRAGTDGKDRERDRDREDRSKDRDRERDRGDREREREKEKEKELRASTNAMLISA----GLP 75

  Fly    88 GLTKAQRSH-------VHRLAQHRGLKTVSKGPEENRVLFISRPQSDGQQQYILCNTKLDICPPL 145
            .|..:..:|       .|.........|...|                       :|.|..|
Mouse    76 PLKASHSAHSTHSAHSTHSTHSAHSTHTGHTG-----------------------HTSLPQC--- 114

  Fly   146 LDVLGQMAGNVERRLMNSVGDLKCNKQQYKDIRLPSNFGLVGQRLIPPPQSNRNRNIQHERRSLP 210
                           :|...:|                          |.:.|..:|..:|..||
Mouse   115 ---------------INPFTNL--------------------------PHTPRYYDILKKRLQLP 138

  Fly   211 IYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVR-IVVSQPRRIAAISVSE 274
            :::.::...::|.|.|..::.|.|||||:||:||:.:|:......|.| :..:||||:||:||::
Mouse   139 VWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQ 203

  Fly   275 RISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERD 339
            |::.|.....|..|||:||.....|:.|:|...|.|.|||....|  ...:....:|:||||||.
Mouse   204 RVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMND--PLLERYGVIILDEAHERT 266

  Fly   340 LDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYHLEDILSKT 404
            |.||.|:...|..:::...|::::||||:|......||....::.:.||:..|.|::
Mouse   267 LATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFY-------- 323

  Fly   405 GYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDID--NDLIVSLLELLLRQGDAGAVIVYL 467
                              ||              .|:.|  ...|.:::::.:.:.:.|.::::|
Mouse   324 ------------------TP--------------EPERDYLEAAIRTVIQIHMCEEEEGDLLLFL 356

  Fly   468 PGYSDMTSLLARLESSLPRE---------QITIILLHSQVDNSEQRKVFRTYP------GVRLKI 517
            .|..::.....|::    ||         .|.||.|:|.:...:|:::|...|      .:..|:
Mouse   357 TGQEEIDEACKRIK----REVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKV 417

  Fly   518 ILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCY 582
            ::||||.:||:||..:::|||.|.||.|.|:..|....|.:|.||:|.|:||||||||...|.|:
Mouse   418 VVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCF 482

  Fly   583 RLY-DNDRMARMNLYTIPEIMRRTLDEICL-LTKLAAPDKKIENFLALALDTPPKDAVMQSCSRL 645
            ||| :......|...|.|||:|..|..:.| |.||...|....:|    :|.|..:.:|::...|
Mouse   483 RLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDF----MDPPAPETLMRALELL 543

  Fly   646 KLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGK 710
            ..|..|::..::|.||.::||.||..|:.|.::.|....|.:.::.|.|..||...||...| .|
Mouse   544 NYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTE-AK 607

  Fly   711 KSGQQISRVLFAG-DGMSDSLAVIKLYEEFTNLKRKDIGDFCERNFI-CRNAMEMFVSAASTLRD 773
            |:..: :::.||. ||  |.|.::.:|..|.  :..:...:|..||| .|:.|     :|..:|.
Mouse   608 KAADE-AKMRFAHIDG--DHLTLLNVYHAFK--QNHESVQWCYDNFINYRSLM-----SADNVRQ 662

  Fly   774 TVYRIF-RFSEASARLASSFNNDTNM--IRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRS 835
            .:.||. ||:  ..|.::.|.:....  ||.||..|.:.::|:::|.. :.|..:.:.:||:..|
Mouse   663 QLSRIMDRFN--LPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTG-HYLTVKDNQVVQLHPS 724

  Fly   836 SCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGSEMLLCLD 900
            :.|       |...||:|:.|...|.                      |.:|.        .|.|
Mouse   725 TVL-------DHKPEWVLYNEFVLTT----------------------KNYIR--------TCTD 752

  Fly   901 ---SWIRLKCPAEFGL----QLHKVRMLTDREFAKL 929
               .|:....|..:.:    |....|.| ||..|||
Mouse   753 IKPEWLVKIAPQYYDMSNFPQCEAKRQL-DRIIAKL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	14/65 (22%)
		DEXDc	214..395	CDD:214692	64/181 (35%)
		DEXDc	226..368	CDD:238005	55/142 (39%)
		HELICc	479..575	CDD:197757	41/110 (37%)
		HA2	648..733	CDD:214852	28/85 (33%)
		OB_NTP_bind	783..884	CDD:285018	20/102 (20%)
Dhx15	NP_031865.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111		22/122 (18%)
		HrpA	124..763	CDD:224557	210/739 (28%)
		DEAH box	260..263		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810