DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8915 and dhx29

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_004910409.1	Gene:	dhx29 / 100216168	XenbaseID:	XB-GENE-995260	Length:	1363	Species:	Xenopus tropicalis

Alignment Length:	1068	Identity:	305/1068 - (28%)
Similarity:	500/1068 - (46%)	Gaps:	167/1068 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VKRGRRQGRKKAQPMPEQAVVLVVNGRVTGGPKGTGKQK-------------TRPGKNAKADAGD 59
            ||...:|.|....|..|:::...:..::...|:...|:|             :..||:.|....|
Frog   318 VKSESKQPRPALPPSDEESLNFNLFEKIENAPEDKAKKKPPLDIRNFDYTSRSWTGKSPKQFLID 382

  Fly    60 KLKSEDEK-------------------MLRQLVDDFLQSCEPEKQLPGLTKAQRSHVHRLAQHRG 105
            ..:...:|                   .:.:..||.:..|      |.:..........||....
Frog   383 WCRKHYQKSPNPSFEKVPVGKYWKSRVKIIKSHDDVMCVC------PTIVTEDSMQAQHLAATLA 441

  Fly   106 LKTVSKGPEENRVLFISRPQ---------SDGQQQYILCNTKLDICPP-------LLDVLGQMAG 154
            |..::||...:::|    |.         ||.::| :....|::...|       ||:.|.....
Frog   442 LYELTKGQSVHQLL----PPTYRDVWLEWSDAEKQ-VQEQNKMESNKPRDQFITKLLNKLKLQQN 501

  Fly   155 NVERRLMNSVGD--------LKCNKQQYKDIRLPS-----NFGLVGQRLIPPPQSNRNRNIQHER 206
            .::....|.|.:        |.|:::|.:  ..||     :...:...|:....|.:.:.:.::|
Frog   502 QLKSSGQNPVTEDPEDSWENLACDEEQIE--TCPSTAQTDDLEPIRNLLLKSRDSIKYKRLLNDR 564

  Fly   207 RSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHR---APVRIVVSQPRRIA 268
            ..||::..|:.||..|:|.:|:::.|.||||||||:||::||....:|   ....||.:|||||:
Frog   565 EQLPVFAHRKFILETLKRHRVIVVAGETGSGKSTQVPQFLLEDLLLNRGSPGKCNIVCTQPRRIS 629

  Fly   269 AISVSERISKERG--EAPG---TTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTT 328
            |:|::.|:.:|.|  ..||   :..||.|||..:....|.|:..|:|.|||.|..|  |..||.:
Frog   630 AMSLATRVCEELGCDSGPGGRNSLCGYQIRMESRTGEATRLLYCTTGILLRKLQED--SMLKNIS 692

  Fly   329 HLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVS 393
            |:|:||.|||.:.:||||:..:..|.|...|.|||||||:|.|..|:||....::.:.||:|.|.
Frog   693 HIIVDEVHERTVQSDFLLIILREILHKRSDLHLVLMSATVDCEKFSSYFTHCPIIRISGRTFPVE 757

  Fly   394 IYHLEDILSKTGYMHPR----MEKFL-----------GK-----------PTGKETPSELLAAY- 431
            ::||||::..||::..:    .:|||           ||           |...:|..:|...|
Frog   758 VFHLEDVVEATGFVLEQDSEYCQKFLEDEEEITLSVTGKGGSSTKYQEFIPALSDTGLDLGQRYQ 822

  Fly   432 -YGGNT-----IVHPD-IDNDLIVSLLELL----LRQGDAGAVIVYLPGYSDMTSLLARLESSL- 484
             |...|     .::|: |:.|||:.||..|    ..:...|||:::|||.:|:..|...|.|..
Frog   823 RYSSQTRHAVLYMNPNKINLDLILELLVFLDISPQYRNVEGAVLIFLPGLADIQQLYDILSSDKR 887

  Fly   485 --PREQITIILLHSQVDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTY 547
              .|.:..:|.|||.:.:.:|.:.|...|....||:|:|||.:|.|||||:::|:|.|..|...|
Frog   888 FHDRRRYKLIALHSILSSQDQAEAFILPPAGTRKIVLATNIAETGITIPDVVFVVDAGRTKENRY 952

  Fly   548 DSTIDASQLTLTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICL- 611
            ..:...|.|..|:||:|.|.||.||||||..|.|:|||..:|......|::|||:|..|:|:||
Frog   953 HESSQMSSLVETFISKASALQRQGRAGRVRDGFCFRLYTRERFEGFMEYSVPEILRVPLEELCLH 1017

  Fly   612 LTK--LAAPDKKIENFLALALDTPPKDAVMQSCSRLKLLGVLD-ERDEVTPLGHIVAELPLGVQI 673
            :.|  |.:|    |:||:.|||.|....:..:.:.|:.:|..: .:..:||||..:|.||:.|:|
Frog  1018 IMKCDLGSP----EDFLSKALDPPQLQVISNAMNLLRKIGACELIQPRLTPLGQHLAALPVNVKI 1078

  Fly   674 GKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEE 738
            ||.|::.....|||::..:||..:.:.|||..|  |:|....:::...| ...||.|.:.:.|..
Frog  1079 GKMLIFGAIFGCLDAVATLAATMTEKSPFVTPI--GEKDRADLAKSSMA-VANSDHLTIFRAYLG 1140

  Fly   739 FTNLKRKDIG---DFCERNFICRNAMEMFVSAASTLRDTVYRIFRFSEA--------------SA 786
            :..::.....   .:|.:||:.|.|:       .|:.|....:.|...|              |.
Frog  1141 WKAIRSDGYAAEMSYCRKNFLNRKAL-------LTIEDVKQELIRLVRAAGFECPRFVEPNGLSD 1198

  Fly   787 RLASSFNNDTNMIRLALTAGLYPKLAYMDRENKNQLVAEGDPLVQVSRSSC-LRGKKKQKDLAS- 849
            .:.:....:|::::..||||||..:..:...|...:..:...:|:.::... :......:||.:
Frog  1199 NMKALSAEETSLLKAILTAGLYDNVGKILFTNSVDITEKLACMVETAQGKAQVHPSSVNRDLQTY 1263

  Fly   850 EWILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFITEAHGSEMLLCLDSWIRLKCPAEFGLQ 914
            .|:|:.||.:.:...  |..:||::...|.|.||.  |...| .|.||.:|.||..:.|.:..:.
Frog  1264 GWLLYQEKIKYSKVF--LRESTLITPFPVLLFGGD--IAVQH-RERLLTVDDWIHFQAPVKIAVI 1323

  Fly   915 LHKVRMLTDREFAKLVATRKLSLMSDFI 942
            ..::|:|.:....|.:...|:||..|.|
Frog  1324 FKELRVLIESVLKKKLENPKMSLQDDTI 1351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	11/77 (14%)
		DEXDc	214..395	CDD:214692	81/188 (43%)
		DEXDc	226..368	CDD:238005	66/149 (44%)
		HELICc	479..575	CDD:197757	39/98 (40%)
		HA2	648..733	CDD:214852	28/85 (33%)
		OB_NTP_bind	783..884	CDD:285018	23/116 (20%)
dhx29	XP_004910409.1	HrpA	556..1281	CDD:224557	240/742 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010