DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8915 and dhx34

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001121459.1	Gene:	dhx34 / 100158553	XenbaseID:	XB-GENE-1009178	Length:	1133	Species:	Xenopus tropicalis

Alignment Length:	1007	Identity:	256/1007 - (25%)
Similarity:	419/1007 - (41%)	Gaps:	277/1007 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 MNSVGDLKC----NKQQY----KDI------RLPSNFGLVGQRLIPPPQSN-----RNRN----- 201
            |...|| ||    :|::|    ||:      |...||.::..:.:...:.|     |:|:
Frog    55 MQKRGD-KCKGRTDKEKYSGSLKDLPKVYDPRYRINFSIIQSKDVEKSRHNHVKEYRSRDCRSIP 118

  Fly   202 ----------------------------IQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGK 238
                                        ::.||.||||::.:|.|::::.:.||:::.|.||.||
Frog   119 REKLEEFKMSVLHYLDFTQKQSFAKLVKLRKERSSLPIFQYKEKIISMVHKHQVVVVAGDTGCGK 183

  Fly   239 STQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTV 303
            |||:|||:|.....|     |..:||||||.||:::|:..|.....|:.|||.||.....|..|.
Frog   184 STQVPQYLLAAGFGH-----IACTQPRRIACISLAKRVGFESLNQYGSKVGYQIRFESSRSPATK 243

  Fly   304 LMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATM 368
            ::..|.|.|||.:..|  |.......:|:||.|||.|.:||||...:..|...|.|:::|||||:
Frog   244 IVFITEGLLLRQIQRD--STLPQYQVIIVDEVHERHLHSDFLLGVLRQLLILRPDLKVILMSATI 306

  Fly   369 DLEALSNYFGGGTVMDVEGRSFEVSIYH----LEDILSKTGYMHPRMEKFLGKPTGKETPSELLA 429
            :::..|.||....|:.|.||.|.:.:.:    .|:.:||:..:.||....:.:....:.|
Frog   307 NIKLFSGYFEQAPVLQVPGRLFPIQVIYQPIPQEETVSKSEKLDPRPYLHVLQAIDHKYP----- 366

  Fly   430 AYYGGNTIVHPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSLLARLESSLPREQITIIL- 493
                      ||                 :.|.::::|.|.::::|:...::......|..|:|
Frog   367 ----------PD-----------------ERGDLLIFLSGVTEISSVQEAVQVYATHTQRWIVLP 404

  Fly   494 LHSQVDNSEQRKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLT 557
            |||.:..::|.|||...| ||| |.|:||||.:||:||..:.:|:|:|..|..::|......:|.
Frog   405 LHSTLSIADQDKVFDLAPVGVR-KCIISTNIAETSVTIDGVRFVLDSGKVKEMSFDPKAKMQRLQ 468

  Fly   558 LTWISQADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTK---LAAPD 619
            ..|||:|.|:||.|||||...|.|||||........:.|.:|||.|..||.:.|..|   |..|
Frog   469 EFWISRASAEQRKGRAGRTGPGVCYRLYAESDYDAFSPYPVPEIQRVALDSLVLQMKSMELGNP- 532

  Fly   620 KKIENFLALALDTPPKDAVMQSCSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLR 684
               .:|  ..::.|...::..:...|:..|.||..:|:||:|.::|:||:.|.|||.|:......
Frog   533 ---RHF--PFIEQPSMSSIETAIFYLRDQGALDINEELTPIGKLLAKLPVDVVIGKMLILGSLFS 592

  Fly   685 CLDSMIIIAAYHSVRDPFV---------------LNIERG---------------KKSGQQISRV 719
            .::.::.||:..||:.|.:               |..|.|               |.:.:..||.
Frog   593 LVEPVLTIASALSVQSPILRNSTSNPEWGTARKPLESEHGDPFTLLNIFNEWVQVKANQRSNSRK 657

  Fly   720 LFAGDGMSDSLAVIKLYEEFTNLKR------KDIGDFCERNFI---------------------- 756
            .....|:.:.    :|| |..||:|      ||.| ..|.|..
Frog   658 WCRRRGLEEQ----RLY-EMANLRRQFKELLKDHG-LLEENVAQRGDRNSRQRQHKERKELHQLK 716

  Fly   757 ---------CRNAMEMFVSAAST-----------------------------LRDTVYRIFRFSE 783
                     .|..:::....|.:                             ||..::.:...|.
Frog   717 RQHERVEKRKRKVLKLQDEGAGSSSDGEEQYHTEKHRKDRKDSIDIQDVKFKLRHNIHELHASSS 781

  Fly   784 ASARLASSFNNDTNMIRLALTAGLYPKLAYMD-----RENKNQL---------------VAEGDP 828
            ....|:|   .:.::::|.:..||||:|...|     |::.:|:               |...:|
Frog   782 TGQDLSS---QEVSLLKLIVCHGLYPQLGVPDSFNSCRKDSDQVFHTKNKQGVVLHPTCVFSCNP 843

  Fly   829 -LVQVSRSSCLRGKK---KQKDLASEWILFVEKTRT-------ADQISSLEHTTLVSGLMVALAG 882
             |:||:......|.:   |.:....:.:.||....|       ..::|:|:...|::..:...|.
Frog   844 ELLQVNSEEESAGNESGNKGQSSRHQIVAFVSLLETNKPYLVNCVRLSALQGFLLLARCIDTSAD 908

  Fly   883 GKRFITE------AHGSEMLLCL-DSWIRLKCPAEFGLQLHKVRM--------------LTDREF 926
            ..|.:.:      ....|..||| ...::|:...|   :|.|.|:              .|.|:.
Frog   909 CCRIVCDKWMEMNVDNPESALCLITEAVQLRVALE---KLLKSRLEKPSRREDHTEDDAWTARQE 970

  Fly   927 AKLVATRKLSLMSDFIGPETV---RRL--LEA 953
            |:.:..|    :.|::.||.:   |||  |||
Frog   971 AERLGRR----LVDYVRPEAIYSMRRLAALEA 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	70/180 (39%)
		DEXDc	226..368	CDD:238005	59/141 (42%)
		HELICc	479..575	CDD:197757	40/97 (41%)
		HA2	648..733	CDD:214852	27/114 (24%)
		OB_NTP_bind	783..884	CDD:285018	25/131 (19%)
dhx34	NP_001121459.1	DEXDc	149..329	CDD:214692	75/186 (40%)
		DEXDc	171..306	CDD:238005	59/141 (42%)
		HELICc	402..488	CDD:197757	40/86 (47%)
		HA2	557..638	CDD:214852	23/80 (29%)
		OB_NTP_bind	762..903	CDD:285018	27/143 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010