DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8915 and dhx37

DIOPT Version :9

Sequence 1:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_005172500.1	Gene:	dhx37 / 100009635	ZFINID:	ZDB-GENE-030131-4505	Length:	1153	Species:	Danio rerio

Alignment Length:	942	Identity:	224/942 - (23%)
Similarity:	363/942 - (38%)	Gaps:	278/942 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GRVTGGPKGTGKQKTRPGKNAKADA----------GDKLKSEDE---------KMLRQLVDDFLQ 78
            ||:.......|:|::...:.|.||.          |..||..|:         |..:|.|:
Zfish     2 GRLRKKHNWKGRQQSTSVQTAAADRQTNVQVEIQDGAVLKGVDDCNALVLPATKTKKQKVE---- 62

  Fly    79 SCEPEKQLPGLTKAQRSHVHRLAQHRGLK-----TVSKGPE------ENRVLFISRPQSDGQQQY 132
              .|..:...|||.||.::.::.:.:..|     .:||..|      |.::|:.:.....|.:.|
Zfish    63 --RPVTKKKALTKKQRKNLEKVLEQKDKKAHRAEVLSKLAEVQLPEAELKLLYTTAKLGTGGKLY 125

  Fly   133 IL---CNTKLDICPPLLDVLGQMAGNVERRL--------------------------------MN 162
            .:   .|...|.....:.:......|.:||.                                ..
Zfish   126 HIKESVNEGQDGGSSSVKISSLSGANRKRRREADEEEEENESEMSESSEDDDDSEESDSSEEEKE 190

  Fly   163 SVGDLKCNKQQ-----YKDIRLPSNFGLVGQR--------------LIPPPQSNRNRNIQHERRS 208
            .:.:.|..::|     .|:...|....:..::              .||   ..|...||..|..
Zfish   191 KISEEKHTEEQQQQQVLKEETKPKEADMKEEKKAETWTKEDCKPAVFIP---VERLPEIQEARLR 252

  Fly   209 LPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRRIAAISVS 273
            ||:..:.:.|:..::..:.:::.|.|||||:||:||::.|........: |.|::|||:||||:|
Zfish   253 LPVLAEEQIIMEAVKDHECVVLCGETGSGKTTQVPQFLYEAGFASSGGI-IGVTEPRRVAAISMS 316

  Fly   274 ERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLIIDEAHER 338
            .|::.|...:.| .|.|.||.....:.||.:.:.|.|.||:.:..|  ...:..:.:||||||||
Zfish   317 HRVATEMNLSSG-VVSYQIRYEGNVTENTKIKVMTDGVLLKEIQRD--FLLQKYSVIIIDEAHER 378

  Fly   339 DLDTDFL--LLA--TKLELQKNPHLRLVLMSATMDLEALSN----YFGGGTVMDVEGRSFEVSIY 395
            .:.||.|  ||:  ..|..:|...::|::||||:.:|..:.    :.....|:.||.|.|.|:::
Zfish   379 SVYTDILIGLLSRIVPLRNKKGLPMKLIIMSATLRVEDFTENKRLFSSPPPVIKVEARQFAVTVH 443

  Fly   396 HLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTI-----VHPDIDNDLIVSLLELLL 455
            .                       .|.||.:    .|.|.|.     :|
Zfish   444 F-----------------------NKRTPMD----DYTGETFRKICKIH---------------- 465

  Fly   456 RQGDAGAVIVYLPGYSDMTSLLARLESSLP----REQ---------------------------- 488
            |....|.::|:|.|.:::.|:..||..:.|    ||.
Zfish   466 RMLPPGGILVFLTGQAEVHSVCRRLRKAFPYKPNREHTDMMETEEDLKKSKRAKKKNVSLPRINL 530

  Fly   489 --------------------------------------------------ITIILLHSQVDNSEQ 503
                                                              :.::.|:|.:...:|
Zfish   531 DNYSALPVDEGDEDRQAGIDEDDGEGSDLELELGDHPDTDHEEKADPSIPLYVLPLYSLLAPEQQ 595

  Fly   504 RKVFRTYP-GVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAK 567
            .||||..| |.|| .:::||:.:||:|||.:.||:|.|..|.:.||.....|...:||||||.|.
Zfish   596 AKVFRPPPAGSRL-CVVATNVAETSLTIPGIKYVVDCGRVKKRFYDRVTGVSSFKVTWISQASAN 659

  Fly   568 QRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLALALDT 632
            ||||||||...|:|||||.:......:|::..||.||.::::.|..|    |..||..:.....|
Zfish   660 QRAGRAGRTEPGHCYRLYSSAVFGDFSLFSEAEITRRPVEDLVLQMK----DLNIEKVVNFPFPT 720

  Fly   633 PPKDAVMQSCSRLKL-LGVLD---------ERDE------VTPLGHIVAELPLGVQIGKCLVYSI 681
            ||....:.:...|.: ||.|:         |.::      ::|||..:|..|:..:..|.|....
Zfish   721 PPSSEALIAAEELLISLGALEKPARHGRLSEMEKARLSCPISPLGRAMAAFPVAPRYAKMLALGR 785

  Fly   682 YLRCLDSMIIIAAYHSVRDPF----------VLNIE-RGKKSGQQISRVLFAGDGMS----DSLA 731
            ...|:..:|.|.:..:||:.|          ..|:: .|||:.....|.|:||.|.|    |.:.
Zfish   786 QQGCMQYIITIVSAMTVREIFEDYDRPAGSEEENVKMSGKKARSVQMRRLWAGQGASLLLGDLMV 850

  Fly   732 VIKLYE--EFTNLKRKDIGDFCERNFICRNAM 761
            ::....  ||..|..:    |||.|.:...||
Zfish   851 LLGAVGACEFAGLTPQ----FCEENGLRFKAM 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8915	NP_001285369.1	R3H	64..123	CDD:100064	16/78 (21%)
		DEXDc	214..395	CDD:214692	63/188 (34%)
		DEXDc	226..368	CDD:238005	54/145 (37%)
		HELICc	479..575	CDD:197757	44/178 (25%)
		HA2	648..733	CDD:214852	28/114 (25%)
		OB_NTP_bind	783..884	CDD:285018
dhx37	XP_005172500.1	HrpA	200..1007	CDD:224557	190/738 (26%)
		DEXDc	272..412	CDD:238005	54/143 (38%)
		HELICc	583..667	CDD:197757	39/84 (46%)
		HA2	730..781	CDD:282288	11/50 (22%)
		HA2	761..>813	CDD:214852	13/51 (25%)
		OB_NTP_bind	<918..1004	CDD:285018
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810